📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)

Good day readers! This week we’ve curated 20 GPCR papers, 3 new events, 9 industry news, and 3 job opportunities! Discover our comprehensive coverage of GPCRs,

We welcome GPCR paper suggestions! Submit your publications to Hello@DrGPCR.com for consideration.

This week's highlight:

• Dr. Matthew T Eddy and his team's research on A2A adenosine receptor activation by G protein and mutations.

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November Dr. GPCR Newsletter is out now. Subscribe for this month's video featuring Dr. Alix Rouault.

Ensure to catch the upcoming episodes of Dr. GPCR Podcast featuring Dr. Neil Grimsey and Dr. Katarzyna Marcinkiewicz.

Be sure to look at the Classified GPCR News from November 27th to December 3rd, 2023.

GPCR Activation and Signaling

• DANGER Signals Activate G -Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma

• Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations

• Distinct activation mechanisms of β-arrestin-1 revealed by 19F NMR spectroscopy

• Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury

GPCR Binders, Drugs, and more

• High-throughput virtual screening of potential inhibitors of GPR52 using docking and biased sampling method for Huntington's disease therapy

• Rational design of highly stabilized and selective adrenomedullin analogs

• Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation

• Flavonoids as G Protein-coupled Receptors Ligands: New Potential Therapeutic Natural Drugs

GPCRs in Cardiology, Endocrinology, and Taste

• Phenylacetyl glutamine (PAGln) enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor

• Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis

GPCRs in Neuroscience

• Targeting sensory neuron GPCRs for peripheral neuropathic pain

GPCRs in Oncology and Immunology

• Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach

• The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis

Methods & Updates in GPCR Research

• Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications

• Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

• GPCR molecular dynamics forecasting using recurrent neural networks

• A method for multiple-sequence-alignment-free protein structure prediction using a protein language model

Reviews, GPCRs, and more

• Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review)

Structural and Molecular Insights into GPCR Function

• Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex

• Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors

Industry News

• Sosei Heptares to take back GPCR agonist after GSK changes course

• All-rounder among receptors inspires drug research

• Tectonic Therapeutic Announces Start of First Clinical Program for GPCR-Targeted Biologic

• Trevena Announces Acceptance of Abstract Examining the Use of OLINVYK in Patients with Acute Burn Injuries

• Carmot Therapeutics Enters into Definitive Merger Agreement with Roche

• New Clinical Trial Explores Novel Target In Parkinson’s Treatment

GPCR Events, Meetings, and Webinars

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• February 11 - 14, 2023 | 2024 BPS Annual Meeting

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• NEW June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• NEW June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• NEW October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Principal scientist – oncology biomarker expert

• NEW Postdoctoral Fellow

• NEW Scientific Assistant

• Scientist

• Lead Researcher

• Post-Doctoral Fellow

• Sr Scientist in Obesity, Muscle, and Metabolism

• Post-Doctoral Fellow

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