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passion, I recently started a postdoctoral fellowship to study the role of GPCRs in the mechanisms of pain

Our first main research aspect is the identification of endogenous ligand of GPCRs. Our second main research aspect is dissecting the molecular mechanism underlying sensation of force, Our third main research aspect is working mechanism of GPCR. Our fourth main research aspect is ligand coding mechanisms and structural aided drug discovery of GPCR

Full Agenda Session V Structural mechanisms of AGPCR signaling and function Structural Determinants Of GAIN Unveiling the GPS Cleavage Mechanism in ADGRL1 with QM/MM Florian Seufert Structural Determinants Of GAIN ADGRs are autoproteo-lytically cleaved at the GPCR proteolysis site (GPS), an HXS/T motif within the GAIN We de-termined the crystal structure of the human ADGRB2/BAI2 hormone receptor (HormR) and GAIN domains domain partially re-instates cleavage, while its deletion reduces cleavage in the ADGRL1 GAIN domain

Home → Flash News → Seeking to gain more knowledge on signaling bias? GPCR Courses Seeking to gain more knowledge on signaling bias?

Mike's lab has two main areas of interest: 1) alternative polyadenylation as a targetable driver of pancreatic He shared that his interest in science originated from a young age and his desire to gain more knowledge However, he decided to undertake another postdoc to gain more experience and confidence. The conversation ended with Yamina expressing interest in learning more about Mike's two main research

Klein's lab where she helped to investigate the role of various ATP-sensitive potassium channels in pain

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Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to

AGPCRs in the periphery The CELSR/ADGRC Homolog Flamingo Is Not Autoproteolytically Processed By The GAIN inflammation Gabriela Aust The CELSR/ADGRC Homolog Flamingo Is Not Autoproteolytically Processed By The GAIN Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing (GAIN We found that the knock-out of cupidon induces a gain in cell adhesion and cell fusion, resembling the

But loss has a way of sharpening focus—friends lost to overdose brought the opioid epidemic into painful

effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN

Working in a lab allows scientists to gain amazing hard and soft skills, which opens the doors to several

Gain valuable strategies to advance your covalent or tight-binding candidates and enhance your experimentation

She has gained experience from working in academia and at GSK as an industrial trainee.

fast-changing field: “Try to keep a finger on the pulse of as much as you can… that was one of the main

My main topics were protein biochemistry, Drosophila husbandry, and genetics. Since then, I have broadened my horizons with many more techniques in vivo and in vitro, with a main

Myeloid Skewing Emmanouil Kyrloglou A single cell GPCR map of thermogenic fat Vasiliki Karagiannakou GAIN and Cancer IDC, Helmholtz Centre Munich" Vasiliki Karagiannakou on the web Helmholtz Centre Munich GAIN aGPCRs predicted two flexible regions, termed flaps, located within the GPCR autoproteolysis inducing (GAIN We are investigating the relevance of GAIN domain dynamics for aGPCR signaling in Drosophila melanogaster Detection of these, as well as 18 other aGPCRs, was confirmed by PCR screening for GAIN/GPS domains on

and his team are working on understanding receptor signaling in specialized cellular environments to gain

Receptors and Hearing and Balance Receptors Bill Huang Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN Proliferation Tobias Langenhan The CELSR/ADGRC Homolog Flamingo Is Not Autoproteolytically Processed By The GAIN adhesion GPCR Signaling and Pharmacology-Enabling Drug Discovery Fabian Pohl Structural Determinants Of GAIN Myocardial Notch Activity and N-cadherin Localization to Attain Trabecular Identity Lara-Sophie Brodmerkel GAIN

structural biology, pharmacology, and pharmacoepidemiology with innovative computational methods to gain

His main research group centers on the function, structure, and regulation of G protein-coupled receptors

effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN ADGRG6 undergoes autoproteolysis at the GPCR-autoproteolysis site (GPS) enclosed within the larger GAIN ADGRG6 NTF has multiple extracellular domains like CUB, PTX, SEA, hormone binding domain, and the GAIN

The main target of Dr.

to the University of Oxford on a 4-year Wellcome Trust Scholarship in Neuroscience, through which I gained

GPCR About Ben Holland "Ben gained his masters in Engineering Science from Oxford, taking a specialisation

The main goal of the GPCR Retreat is to provide a venue for students, post-doctoral fellows, and principal

Adhesion GPCRs GPR110 and GPR116 Tingzhen Shen Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN describe the cryo-EM reconstruction of an aGPCR, Latrophilin3/ADGRL3, and reveal that the conserved GAIN GAIN-targeted antibodies, and cancer-associated mutations at the GAIN-7TM interface, alter holoreceptor Tingzhen Shen on the web University of Michigan Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN

provide an ideal case study for quantitative, and multi‐scale integration of these amounts of data to gain

Ribeiro main scientific contributions include the study of the mechanisms involved in neurodegeneration

During his last year of studies, Timo performed research in the biopharmaceutical company Argen X and gained