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chemokine receptors with their cognate chemokine ligands is generally described by the two-step/two-site algorithm (Steentoft C et al. 2013) for O-glycosylation and the sulfinator tool for tyrosine sulfation sites receptor 2 (ACKR2), US28 and sphingosine-1-phosphate receptor 1 (S1PR1) also carry tyrosine sulfation sites The interplay between these PTMs was also revealed where mutagenesis of tyrosine sulfation sites considerably The combined effects of both PTMs as well as the relevance of specific acceptor sites and glycan composition

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Although studies have focused on the G-protein signaling state, the mechanism for β-arrestin signaling

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August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of

"We recently hosted our annual Scientific Advisory Board (SAB) summit at our site within Granta Park.

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TAVNEOS will receive marketing authorization in all member states of the European Union, as well as in

With the United States Food and Drug Administration's designation of psilocybin as a "Breakthrough Therapy

processes and regulation of a wide range of immune responses in different physiologic and pathologic states

Terry Kenakin reframes GPCRs as dynamic, allosteric sensors—far from static binding sites. What you’ll learn: Reveal cryptic binding sites and time-dependent interactions.  

Here we found a key mechanical site that modulates the collective dynamics of the receptor and used this This study provides a computational pipeline to detect precise druggable sites and identify allosteric

well as the conditions in which neuropeptides directly mediate physiological and adaptive behavioral states

The VFT module of TAS1R2 contains the primary binding site for most of the sweet-tasting compounds, including However, cellular assays, molecular docking and site-directed mutagenesis studies have revealed that

We review the current state of CB2 ligand development and progress in optimising physicochemical properties

We review the current state of CB2 ligand development and progress in optimizing physicochemical properties

New high-resolution structures of CB1 receptor in different functional states have significantly improved

present two cryo-electron microscopy structures of CX3CR1-Gi1 complexes in ligand-free and CX3CL1-bound states

elucidate the molecular mechanisms responsible for these effects of RNA editing, we present four active-state

We are able to identify the interaction of membrane cholesterols with definite sites and domains within cholesterol consensus motif (CCM), which may well steer cholesterol into the hitherto identified binding sites

conformational changes in the GABABR transmembrane domain (TMD) to form an intermediate pre-activated state

mechanistically distinct and cell type–specific roles for C3aR in regulating innate immune cell inflammatory state

gained traction rapidly due to their biochemical tractability and their ability to recognize defined states

In the United States, DNA Day was officially celebrated on April 25th, 2003. United States. https://www.genome.gov/ Dixon, R. A., Kobilka, B. K., Strader, D. J., Benovic, J.