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regulators and as mediators of distinct signaling pathways through partners including GIT1. and their signaling pathways in the liver and in liver disease. For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

<< Back to podcast list Strategic Partner(s) Anything BUT GPCRs with Dr. All my formal training was in the area of signal transduction, and I continued to work on this area since communication via heterotrimeric G-proteins (Gαβγ) because they represent major intracellular hubs of signaling GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

January 2021 and has contributed to multiple projects exploring the underlying mechanisms of biased signaling These previous endeavors involved exploring the effect of subcellular location on the signaling profile biased ligands, elucidating the role of site-specific receptor phosphorylation in the differential signaling She is currently working on her senior thesis which involves identifying the non-canonical signaling GPCR Podcast? Leave a Review.

, and microbiome-host signaling Key Insights from the Conversation Why Membrane Proteins Wouldn't Crystallize Marshall's team at GSK cloned GABA-B1, tried to get it to signal, and couldn't. Marshall in the room — a new category of GPCR biology opened, with heterodimers as obligate signaling The shift came through the tumor microenvironment — immune cells, chemokine receptors, adenosine signaling readability. 00:00 Welcome and guest introduction 02:32 How an undergraduate lecture on β-adrenergic signaling

research program is to gain a thorough and mechanistic understanding of processes that control cell signaling The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and GPCR Podcast? Leave a Review.

<< Back to podcast list Strategic Partner(s) GPCR location matters with Dr. In my PhD, I studied the nanoscale spatial organization of G protein-coupled receptors (GPCRs) at the and signaling. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor signaling GPCR Ecosystem Great Lakes GPCR Retreat on the web 21st Great Lakes GPCR Retreat More about previous GPCR Retreat meetings Dr.

pain pathway What it means to “teach AI protein dynamics,” and how Superluminal is using it to predict signaling structure-function relationships and predict biased signaling with precision. led Ajay Yekkirala to reshape the future of GPCR-targeted medicine. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling pharmacology; 2006) before starting his independent research team "Receptor Biology & Signalling" in General Research Interest: The focus in the Schulte lab is on Frizzled signaling and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology, physiology, and disease. WNT-receptor interaction, the relevance of receptor dynamics, and receptor complex composition for signal

Annabelle’s Ph.D. work focuses on microbial-derived metabolites that signal through GPCRs expressed in In particular, she is looking at L- and D-lactate-activated HCAR1 signaling. GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling He continues to pioneer in drug discovery studying GPCRs and other target classes. His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling He continues to pioneer in drug discovery studying GPCRs and other target classes. His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

She identified the structural determinant controlling biased signaling of melatonin type 2 receptors when signaling in endosomes by forming a megaplex. Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling Her subsequent work has focused on understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded GPCR Podcast? Leave a Review.

Angers is an expert in the field of signal transduction. Moon , where he identified and characterized novel components of the Wnt signaling pathway and a new He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction. His research program is developed to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and their signaling mechanisms in development, adult tissue homeostasis,

regulating appetite, metabolism, and the immune system, and the molecular mechanisms underlying the signaling and regulation of their GPCRs. where he is now Associate Professor, establishing a lab focused on G protein-coupled receptor kinetics, signaling GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

the past two decades, his lab has published numerous groundbreaking findings shedding light on the signaling Most recently, his lab has made a number of seminal contributions to understanding the signaling, regulation receptor signaling and/or trafficking. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling Current efforts aim to understand the regulation of GPCR and beta-arrestin signaling in the heart and GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

pharmacology while performing various cell-based experiments to understand the binding, activation, and signaling of therapeutically relevant GPCRs. activation and signaling. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

<< Back to podcast list Strategic Partner(s) Empowering Drug Discovery for the GPCR Community with Dr technologies to solve broad questions in pharmacology, with a specific focus on G-protein coupled receptor signaling GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

spanned chemokine receptor conformational dynamics at the Université de Montréal, CXCR3 splice-variant signaling Tom Sakmar's lab, where she characterized the signaling diversity of three alternative splice variants Splice variants aren't just structural — they signal differently. question from Tom Sakmar, demonstrated that variants encoded by the same gene can recruit different signaling The implication: transcript-level diversity is itself a signaling mechanism, not a cloning artifact to

understanding the role of the membrane microenvironment in the subcellular organization, trafficking, and signaling of GPCRs. the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

just two beta-arrestin isoforms to regulate their signaling, endocytosis, and degradation. open questions: how do just two beta-arrestin isoforms, structurally nearly identical, mediate the signaling Shukla's lab and others have shown they signal robustly through beta-arrestins — which makes them, in is harder than the opioid story suggested The neat bifurcation between G-protein and beta-arrestin signaling Jawaharlal Nehru University in India and it was during a biochemistry class where he learned about cell signaling

Terry Kenakin on detecting, quantifying, and applying receptor signaling bias in GPCR drug discovery. 2026 at 3:00:00 PM UTC Register Today 🤝 Webinar in collaboration with: Eurofins DiscoverX Receptor Signaling receptors can signal through multiple intracellular pathways, and ligands do not necessarily engage This phenomenon, receptor signaling bias or functional selectivity, is now recognized as a meaningful This webinar explains the biological basis of signaling bias, shows how to detect and quantify it using

receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor signaling GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr. GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Enjoying GPCR Podcast? Leave a Review.

Gasser " I received my BS and MS in Zoology & Physiology at the University of Wyoming, where I studied signaling Lowry's lab, examined the role of organic cation transporter 3 (OCT3) in the regulation of monoamine signaling Research in my lab is currently focused on understanding the signal transduction pathways activated by GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit signals. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Since 2001, he holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. He is a world-renowned expert in the field of cell signaling and GPCRs and made seminal contributions In addition to paradigm shifts including inverse agonism, biased signaling, and pharmacological chaperones GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

, particularly the receptor family I have been investigating ever since: adhesion GPCRs. Würzburg, where I later became Heisenberg Professor for 'Physiology and pathophysiology of mechanoceptive signalling GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

of the Adhesion GPCR Latrophilin-1. mediate classical G protein signals into cells but can also communicate solely via their N termini. Today, she and her team are working on the questions of how Adhesion GPCRs integrate the different signals GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.