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Results found for "Mark Schmeizl"
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
Extracellular signal-regulated kinases (ERK), a subset of the mitogen-activated protein kinase (MAPK) Spatiotemporal regulation of the p42/p44 MAPK pathway. Biology of the Cell, 93(1‐2), 71-79.
- Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for...
include chronic cough, in addition to the rights to develop certain retained compounds for Charcot-Marie-Tooth
- GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
of PAR2 by GB83 markedly elicited an increase in intracellular calcium levels and phosphorylation of MAPKs
- Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
not female mice exhibited elevated anxiety levels in the open field, elevated plus maze, and light-dark
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
ubiquitin E3 ligase MDM2, thereby activating its downstream signaling pathways such as NF-κB, PI3K/AKT, and MAPK
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
In all dark-adapted transgenic lines, Gαt1 was targeted to the outer segments, reversing its diffuse
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
light chain 3 beta; MKI67: marker of proliferation Ki-67; MTOR: mechanistic target of rapamycin kinase; MAPK
- 📰 GPCR Weekly News - January 9 to 15, 2023
The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream
- Decoding β-Arrestins: from Structure to function
Originally recognized for inhibiting G protein signaling, they also influence specific pathways such as MAPK include nuclear magnetic resonance (NMR) spectroscopy for conformational dynamics analysis context (Park This includes proteins like AP-2 and clathrin, vital for internalization, as well as MAPK cascade kinases
- Assay Sensitivity: The Hidden Lever Driving GPCR Drug Discovery
Conversely, a weak signal in a baseline assay may mask an opportunity—if the system were tuned differently But some leak current, like a switch glowing faintly in the dark.
- 📰 GPCR Weekly News, January 15 to 21, 2024
G-Protein Coupled Receptor Gpr-1 Is Important for the Growth and Nutritional Metabolism of an Invasive Bark
- Chemokine receptor-targeted drug discovery: progress and challenges
and induces different patterns of receptor recycling where CCR5 recycles back to the cell surface (Mack
- 📰 GPCR Weekly News, June 17 to 23, 2024
protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
Intermolecular Dark Resonance Energy Transfer (DRET): Upgrading Fluorogenic DNA Sensing.
- Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
An equivalent volume of assay buffer was added to association controls (filled dark blue circles).



