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We are bursting with pride in sharing it with you, and we sincerely want to thank you for your support That's right, all the tidbits below will be for Premium Members ' eyes only. Septerna Touches New High, To Report SEP-786 Data In Mid-2025 How GPCR agonists, including antibodies, are shaping

because the target is wrong—but because the chemical matter  interacting with that target lacks the right In this lesson, you’ll gain: A strategic view of how chemical scaffolds shape pharmacologic outcomes Those who learn now will shape the drugs others spend the next decade trying to understand. 40 years

Overcoming them requires careful assay design and strategic use of the right fluorescent probes. Source: Way GP, Sailem H, Shave S, Kasprowicz R, Carragher NO. CB 2 -expressing HEK cell lines are labeled with CELT-331 at 80 nM (right), while competition with the

Advantages of Fluorescent Ligands in GPCR Drug Screening for CNS Choosing the right tools is important for the success of drug discovery, just as much as choosing the right targets.

The differentially expressed genes (DEGs) and weighted correlation network analysis (WGCNA) were performed

... and honestly, like with the trials, they were not really that sufficiently better than opioids, right

GPCR Updates   We want your feedback - Help shape the future of Dr. GPCR.   Your voice matters. Every insight you share helps us build a smarter, more supportive GPCR community—together. GPCR Ambassador - Share & refer with Dr. GPCR.   Help grow the GPCR community by joining the Dr. It’s a simple way to share valuable resources and support the field—one connection at a time.  

Shape the next generation of cellular biochemistry research. scientists and translational teams, Premium keeps you informed on the science, careers, and business moves shaping Those who act on the right signals today will lead tomorrow’s breakthroughs—and avoid delays others won

Or the right things are moving in the wrong order. 👉 That’s how biotech teams burn through capital without Real biotech traction starts when decisions are driven by shared strategy, not disconnected deliverables these lines blur, so do accountability and execution. 3️⃣ The third and hardest shift is restoring shared But the moment they shift from disconnected workstreams to a shared, milestone-driven roadmap tied to

Moreover, independent of glucose control or weight loss, the anti-inflammatory actions of GLP-1RAs require

4️⃣ Comparative value: Have you positioned your therapeutic against the right standard or competitor, 5️⃣ Patient targeting rationale: Are you selecting the right patient subgroup with a clear justification

strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary restrictions and weight

Additionally, new studies reveal how phosphorylation barcodes shape arrestin engagement, a biased NTSR1 Ilana Kotliar share how three decades of curiosity evolved into a tech-powered platform for mapping GPCR-RAMP GPCR Publication Highlights     GRK-Specific Phosphorylation Barcodes Shape Arrestin Engagement with

As we approach the event, we have some news to share: We’ve decided to make this event a trainee day Industry News Data shows nearly 19% weight loss in people with overweight or obesity in Boehringer Ingelheim

latest episodes → Read our podcast highlights Inside Revvity’s GPCR Journey: How Decades of Discovery Shaped Acting on the right signals today prevents tomorrow’s delays—and puts you ahead when budgets and timelines

Watch Episode 172 What happens when the career you planned no longer feels right? And so, that certainly shaped my interests and passions as a scientist."

At one point, he even questioned whether research was the right career for him. with chemists, biologists, and pharmacologists not only made his predictions more useful, but also shaped Good mentors help shape thinking without prescribing decisions.

If you want to share your work with our community, please don’t hesitate to fill out this form. You'll share your contributor articles with the community, stay updated with GPCR literature, join a Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors A Bright

Bright illumination triggered Gαt1 translocation from the rod outer to inner segments in all three transgenic

GPCR Podcast, she shares how her background in medicinal chemistry paved the way to co-founding Celtarys , a company now shaping the future of GPCR assay tools.

That's right, you're about to level up your knowledge game! keep you on your toes  Direct line to all the cool cats in the GPCR community - Networking is key, right

A clear, strategic pitch doesn’t just share information. It communicates that you know who you’re building for, why now is the right time, and how your solution

Chemokines are low molecular weight proteins that their functional activities are achieved by binding

affinity metrics alone, often overlooking how kinetic profiles  (onset and offset rates) fundamentally shape and how long it stays bound (k₂)  can alter therapeutic profiles dramatically, even if two candidates share Kenakin’s lecture guides you through key questions that should shape your decision-making process: Are Don’t Let Outdated Models Slow Your Next Program The analytical tools that shaped traditional affinity

Right panel, the fluorescent signal is displaced when, after incubating with CELT-327, cells are incubated

translational strategy, this is where 40 years of pharmacological insight meets the questions you’re asking right

New generations of fluorophores with improved photostability and brightness will enhance assay sensitivity

But HCS only works when assays are built with rigor and powered by the right fluorescent ligands.

weekly lesson help you apply key concepts like binding, signaling, and kinetics in practical, decision-shaping Maria Majellaro shares her journey to founding Celtarys in "From Lab to Leadership".

Heptares to receive US$2.5 million milestone payment from Formosa Pharmaceuticals Are GLP-1s finding the right