Terry Kenakin on how allostery and biased signaling rewrote receptor pharmacology, and why the assay ) Terry Kenakin: Allostery, Bias, and the Assays That Changed What We Could See SCIENTIFIC ABSTRACT Receptor describing a drug as if a single number could carry it: one potency, one efficacy, one response per receptor He works on receptor pharmacology, allosteric protein function, and drug discovery, with a long focus Twenty some receptors and roughly fifty chemokines were long read as a fail safe arrangement.

In my PhD, I studied the nanoscale spatial organization of G protein-coupled receptors (GPCRs) at the Importantly, my work revealed heterogeneous spatial patterns of receptor density and activation, that Alice Ting developing programmable receptors for molecular sensing and controlling cellular behaviour

at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor postdoctoral research in Oxford, investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis.

Terry's Pharmacology Corner What you'll learn during the session: How functional system sensitivity for receptor the antibodies in their own labs and give structured feedback 📅 June 25, 2026 at 11:00:00 AM Details Receptor GPCR webinars are free, live online scientific sessions focused on G protein-coupled receptor biology Whether you're deep in receptor biology or evaluating assay tools, these sessions are built for you. Every session is grounded in receptor biology with a focus on what's practical and applicable.

journey highlights the transition from general drug development to a deep dive into G protein-coupled receptors at the University of Michigan, Ben focuses on positive allosteric modulators (PAMs) targeting opioid receptors thiazolidines and xanthinediones, Ben is helping define how structurally different PAMs may act on similar receptor from the University of Minnesota in 2022, studying the pharmacokinetics and pharmacodynamics of NMDA receptor determining the mechanisms of action of a series of positive allosteric modulators of the mu-opioid receptor

, and a near-total absence of characterized ligands, these receptors long resisted the molecular tools The work connects receptor biology to neuropsychiatric disease: addiction, autism spectrum disorder, Scientific Themes of the Conversation Adhesion GPCRs as a distinct receptor class — autoproteolytic architecture disorder, schizophrenia, and cancer The structural bottleneck: what cryo-EM cannot yet capture about receptor What the field still cannot do is observe the dynamics of receptor assembly, complex formation, and signaling

the early days of ion channel chemistry to pioneering peptide–fluorophore conjugates for the GLP-1 receptor Why targeting the pharmacologically relevant surface-exposed receptor pool changes the way scientists The moment when super-resolution imaging revealed nanoscale receptor domains that conventional tools lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand receptor

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

Research (IMSR) of the University of Birmingham and Co-Director of the Centre of Membrane Proteins and Receptors physicists, engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor that GPCRs are not only active at the plasma membrane but also at intracellular sites and that these receptors

Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors Yamina Berchiche had a detailed conversation about the intricacies of cell signaling and chemokine receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor

his UC San Diego postdoc Krishna Sriram, he reread the literature on ACE inhibitors and angiotensin receptor His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors , cyclic AMP regulation, and receptor biology across tissue systems. If the virus disrupts one arm of this receptor-peptide system, the therapeutic question stops being " Type II pneumocytes carry the highest beta-2 receptor density in the body.

vitro efficacy studies Functional Pharmacology & Binding Expertise cAMP, β-Arrestin, calcium flux, receptor characterization of GPCR activity and function Capabilities span the key endpoints that describe how a receptor Signature panels Peptide Hormone Class B Panel Functional coverage of Class B GPCRs, the peptide hormone receptors Resource Guide GSIS Flyer Metabolic Disorder CNS Rapid Functional Cell-Based Activity Profiling of Multi-receptor

fluorescence spectroscopy and microscopy methods that read these sensors, published case studies on receptor She engineers GPCR biosensors and uses fluorescence spectroscopy to follow receptor dynamics and signaling expansion and bioorthogonal labeling to build a panel of single-color biosensors for the M2 muscarinic receptor

peptide agonist mechanism that differed from the common example known at the time, protease activated receptors Adhesion GPCRs pre-cleave themselves and the two resultant fragments of the receptor remain together adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor

The same library has produced antibodies against orphan GPCRs and receptors without peptide ligands, bivalent IgG, the team hands functional biology teams a molecule that is ready for flow cytometry and receptor Receptors within a family share sequence and surface topography, so an antibody recovered against one 09:17 Why antibodies to GPCRs have stayed so intractable 09:29 The motif-directed library — encoding receptor motifs into CDR3 12:34 Why one antibody can open up a whole receptor family 14:36 Eight to ten weeks

endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors

also went on to discover a “counterion switch” in visual pigments and to develop strategies to assay receptor-G-protein Many of the conceptual advances that stemmed from this work, such as the concept of “functional micro-domains ” and the “helix movement model of receptor activation” were confirmed later when crystal structures , the parallel development of bioorthogonal labeling strategies to couple fluorophores to expressed receptors

Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor at The Rockefeller University, where she study’s the signaling and degradation of G protein-coupled receptors to understand the mechanism by which a new class of biased allosteric modulators for the neurotensin receptor

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Sachdev pursued Ph.D. in the same lab where she investigated the molecular pharmacology of cannabinoid receptors

assistant at the Victor Chang Cardiac Research Institute where he investigated the orphan G protein-coupled receptor Brendan is now a final year PhD candidate in the Orphan Receptor Laboratory headed by Associate Professor

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor

Craig Malbon at SUNY Stony Brook studying the role of G-protein coupled receptors (GPCRs) and their regulators discussed his research on cell polarity and its role in cancer progression, his work on G-protein coupled receptors they face in studying GPCRs due to their low expression levels and the difficulty of localizing these receptors He also discussed his work on G-protein coupled receptors (GPCRs) in breast cancer, identifying GPR161 they face in studying GPCRs due to their low expression levels and the difficulty of localizing these receptors

focuses on the mechanisms underlying biased signaling at GPCRs, specifically, the role of differential receptor He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

Hannes Schihada Following studies in Pharmacy in Regensburg, Germany, I joined the receptor pharmacology I spent 2 1/2 years in his lab and developed novel conformational sensors for these intriguing receptors

sedative that prolongs exhalation and induces bradycardia—acting through alpha-2 adrenergic, not opioid, receptors investigates how fentanyl and xylazine shut down breathing through different mechanisms—work that blends receptor Listen now and see how one scientist is turning molecules into a mission, bridging the gap between receptor

Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin , sigma receptors Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP

developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed from other receptors this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors