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Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the globally-recognized expertise in bioluminescence resonance energy transfer (BRET) technology, including his patented Receptor-Heteromer Investigation Technology (Receptor-HIT) for studying heteromers.

Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career journey and his contributions to the field of pharmacology, with a focus on allosteric receptors and They also discussed their own research on chemokine receptors and the importance of understanding the and GRKs, with Arthur recounting his initial collaboration with Patrick Sexton on RAMPs and amylin receptors They also delved into the different signaling of Class B receptors and the potential for modulation at

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

pools with precision Tissue-level insights reshaping metabolic disease research What’s next: multiplex receptor labeling + AI-designed tools If GLP-1R biology, receptor trafficking, or advanced imaging are part of

Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core.

degree in biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors They also discussed the challenges of studying metabolites and their receptors, the relationship between Challenges in Studying Metabolites and Receptors Claudia and Yamina discussed the challenges of studying metabolites and their receptors, particularly in relation to fermented foods. They also explored the potential for better tools to understand and discover new metabolites or receptors

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor postdoctoral research in Oxford, investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis.

Research (IMSR) of the University of Birmingham and Co-Director of the Centre of Membrane Proteins and Receptors physicists, engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor that GPCRs are not only active at the plasma membrane but also at intracellular sites and that these receptors

Michelle describes how reading those early papers on lipid-rich domains and GPCR–G protein compartmentalization reframed her view of receptor pharmacology. Michelle describes how reading those early papers on lipid-rich domains and GPCR–G protein compartmentalization reframed her view of receptor pharmacology.

endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors

This is the kind of advance that matters for anyone building tools, assays, or therapeutics around receptor If your team relies on receptor visualization — discovery, screening, translational work — this story

Jens Carlsson challenges scientists to go beyond explaining data — and start predicting the future of receptor With tools like AlphaFold , his lab can now model receptor–peptide complexes in seconds — an achievement

journey highlights the transition from general drug development to a deep dive into G protein-coupled receptors at the University of Michigan, Ben focuses on positive allosteric modulators (PAMs) targeting opioid receptors thiazolidines and xanthinediones, Ben is helping define how structurally different PAMs may act on similar receptor from the University of Minnesota in 2022, studying the pharmacokinetics and pharmacodynamics of NMDA receptor determining the mechanisms of action of a series of positive allosteric modulators of the mu-opioid receptor

explore the development of powerful multiplex tools designed to map GPCR-RAMP interactions across the receptor That curiosity laid the foundation for a broader investigation into receptor activity-modifying proteins The lab’s early partnership with students like Emily Lorenzen catalyzed a transition from single-receptor From Many to One: De-Orphanization and Precision Focus “You can use this system to de-orphanize receptors Instead of focusing on a single receptor, students now gravitate toward platforms , biosensors , and

and worked closely with Dr Birgitte Holst studying structural and mechanistic properties of ghrelin receptor associated with obesity and other metabolic diseases, including GPR10, Melanocortin 4, Serotonin 2C and TRH receptors cell-based in vitro technologies to study mechanistic properties of GPCRs and understanding the dynamics of receptor Jacek shared his fascination with the growth hormone secretion receptor and the melanocortin 4 receptor Yamina, in turn, talked about her work on melanocortin receptors and an upcoming collaboration with a

Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor localized in the developing and adult synapses and interact with synaptic scaffold proteins and glutamate receptors Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor

the early days of ion channel chemistry to pioneering peptide–fluorophore conjugates for the GLP-1 receptor Why targeting the pharmacologically relevant surface-exposed receptor pool changes the way scientists The moment when super-resolution imaging revealed nanoscale receptor domains that conventional tools lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand receptor

Graciela Pineyro’s love for GPCR pharmacology started in Uruguay where she first worked on the serotonin receptors Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Sachdev pursued Ph.D. in the same lab where she investigated the molecular pharmacology of cannabinoid receptors

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels GPCRs in regulating renal and cardiovascular function, and identifying renal/cardiovascular olfactory receptor

peptide agonist mechanism that differed from the common example known at the time, protease activated receptors Adhesion GPCRs pre-cleave themselves and the two resultant fragments of the receptor remain together adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor

Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

reframed her view of receptor pharmacology. Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. Why receptor location matters as much as receptor type. October 27, 2025 Terry's Corner Read full article Receptor pharmacology has evolved. Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor

Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein coupled receptors remoulade (remo) gene is a homologue of the vertebrate aGPCR ADGRA family, sharing the same overall receptor domain structure. We found that the receptor is cleaved despite the lack of a consensus GPS sequence. Langenhan where I am studying and characterizing newly generated adhesion GPCR receptors in Drosophila

sedative that prolongs exhalation and induces bradycardia—acting through alpha-2 adrenergic, not opioid, receptors investigates how fentanyl and xylazine shut down breathing through different mechanisms—work that blends receptor Listen now and see how one scientist is turning molecules into a mission, bridging the gap between receptor ecosystem , GPCR training program , GPCR podcast , opioid pharmacology , xylazine research , mu opioid receptor

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid receptors There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity

assistant at the Victor Chang Cardiac Research Institute where he investigated the orphan G protein-coupled receptor Brendan is now a final year PhD candidate in the Orphan Receptor Laboratory headed by Associate Professor

pharmacology, and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor identify human signaling systems and thereby discovered endogenous peptides activating several orphan receptors