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also went on to discover a “counterion switch” in visual pigments and to develop strategies to assay receptor-G-protein from this work, such as the concept of “functional micro-domains” and the “helix movement model of receptor homology modeling, molecular dynamics simulations and coarse-grain sampling approaches for membrane proteins photo-crosslinking,” and more recently, the parallel development of bioorthogonal labeling strategies to couple fluorophores to expressed receptors and other membrane proteins has allowed the creation of novel sensor

by protein kinase C. She identified the structural determinant controlling biased signaling of melatonin type 2 receptors Robert Lefkowitz , which led to the finding that both β-arrestin and G protein can simultaneously bind Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling by the vasopressin type 2 receptor.

Alfred Gillman , co-recipient of the 1994 Nobel Prize in Physiology or Medicine for their discovery of G-proteins That summer, he used radioligand binding methods to dissect receptor function from the adenylyl cyclase From that point on, Paul was hooked and has since studied receptor function in human physiology, receptor Today, Paul and his team focus on previously unrecognized receptors with the hopes to use these as novel

G. Aditya Kumar About Dr. G. Aditya Kumar Dr. at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor G.

The main focus of his lab’s research is on the mechanisms underlying biased agonism at chemokine receptors The chemokine system is relatively unique in having multiple receptors and multiple ligands that display His group and others have shown that many of these ligands act as biased agonists for the same receptor identifying novel signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins.

multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure data, G protein and arrestin coupling and more.

multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure data, G protein and arrestin coupling and more.

approaches to quantify ligand bias and the identification of ACKR3 as an endogenously beta-arrestin-biased receptor His group and others have shown that many of these ligands act as biased agonists for the same receptor identifying novel signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins.

GPCRs, Receptors of Infinite Variety When asked about his favorite GPCR, Nicoli refused to pick. .” – Alessandro Nicoli He emphasized that olfactory receptors , while underexplored, present an incredible Modeling the Invisible: Olfactory Receptors Nicoli’s work centers on predicting ligand binding and receptor – Alessandro Nicoli He shared a detailed case study of working on a specific odorant receptor (R5VK1) His research focuses on a group of 400 transmembrane proteins known as olfactory receptors, which mediate

Canada where she obtained her Ph.D. at the University of Western Ontario, working on the regulation of G proteins signaling by accessory proteins, such as RGS proteins and GPSM proteins.

Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career journey and his contributions to the field of pharmacology, with a focus on allosteric receptors and Allosteric Modulation and Drug Discovery Yamina and Arthur delved into the complexities of protein-protein They discussed various modulatory elements, such as RAMPs, G proteins, and GRKs, with Arthur recounting his initial collaboration with Patrick Sexton on RAMPs and amylin receptors.

Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid receptors pharmacology and has published seminal papers where he used various approaches to describe the role of opioid receptors anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid receptor his group reported the first in vivo GPCR interactome, revealing an important number of new potential proteins

Product Manager at Gator Bio , a biotechnology company providing solutions to researchers studying protein-protein John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid receptors There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity

explore the development of powerful multiplex tools designed to map GPCR-RAMP interactions across the receptor That curiosity laid the foundation for a broader investigation into receptor activity-modifying proteins The lab’s early partnership with students like Emily Lorenzen catalyzed a transition from single-receptor From Many to One: De-Orphanization and Precision Focus “You can use this system to de-orphanize receptors Instead of focusing on a single receptor, students now gravitate toward platforms , biosensors , and

interest in the cardiovascular system by investigating the structure of the Angiotensin and Urotensin receptors Alfred Gilman , Nobel Laureate for his discovery of G proteins, Dr. pharmacology of latrophilins brings about a great deal of challenges given that they are highly polymorphic proteins

Instead, he ended up getting interested in membrane protein as he followed the biology of a bacterial Today he and his team are working on understanding receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological settings with a special interest in His favorite GPCR is the angiotensin 1 receptor, especially for its ability to activate a large variety

, study multiple targets and signaling pathways, investigate target species variations, deorphanize receptors , and more Comprehensive Coverage >1500 Human GPCRs products, including: 90% Target coverage Orphan receptors cell line backgrounds Multiple Mechanisms of Actions (MOA) cAMP accumulation β-Arrestin recruitment Receptor validated portfolio for obesity and diabetes GPCR targets, including GLP-1, GIP, GCG, MC4, PYY, AMY receptors Apelin (APJ/AGTRL1) View representative data: GLP-1R multi-MOA profiling Eurofins DiscoverX's GLP-1 receptor

Fellow, and Director of the Australian Research Council Centre for Cryo-electron Microscopy of Membrane Proteins in the study of GPCRs, biased agonism, and also on allosteric interactions between GPCRs and other proteins , a corresponding member of the International Union of Basic and Clinical Pharmacology Committee on Receptor

Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr.

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor Senior Principal Research Fellow and Director, ARC Centre for Cryo-electron Microscopy of Membrane Proteins

In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and

and received my Ph.D. in Molecular Medicine in 2010 after studying the orphan atypical cannabinoid receptor I was fascinated by the multitude of processes that are regulated/dysregulated by GPCRs and RGS proteins A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and I studied the function of RGS5, calcium-sensing receptor, and an orphan adhesion GPCR, GPR64/ADGRG2 in

From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar ligand concentrations, her work highlights why receptor localization and protein complex assembly matter Inside This Episode How ultrasensitive GPCR signaling emerges from pre-assembled receptor–effector complexes Why receptor localization and scaffolding dramatically shift functional readouts in disease models. The moment when femtomolar ligand concentrations uncovered unexpected receptor sensitivity.

designed to assess the kinetics of unlabelled compounds (and chemical fragments) and the use of purified receptor / effector proteins as tools for drug discovery. " Dr.

John and his team focus on understanding how signal transduction cascades downstream of the opioid receptors work, including the unique organization of chaperone protein Hsp90 modulation of opioid signaling in

His interests are in receptor pharmacology, allosteric protein function, and drug discovery. Dr.

Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr.

. << Back to podcast list Strategic Partner(s) Scaling GLP 1 Receptor Tools Through Academia Industry access aren’t planned from the start Why fluorescence-based assays outperform antibodies for studying receptor focuses on bottom-up chemical tool development for imaging and interrogating GPCRs and other cell-surface proteins His research focuses on class B GPCRs, including the GLP-1 and GIP receptors, with an emphasis on understanding how these receptors operate within complex tissues such as the pancreas and brain.

Among other projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination early tasks at Michelle’s lab, which involved creating stable cell lines and identifying potential protein the potential of multiplexing assays in expanding the scope of scientific exploration and finding new protein Yamina shared her experiences at Rockefeller, where she studied chemical receptors.

the early days of ion channel chemistry to pioneering peptide–fluorophore conjugates for the GLP-1 receptor Why targeting the pharmacologically relevant surface-exposed receptor pool changes the way scientists The moment when super-resolution imaging revealed nanoscale receptor domains that conventional tools Berlin, focusing on developing fluorescent chemical tools to visualize GPCRs and other cell-surface proteins lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand receptor