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If you want to check out the Materials and Methods section as well as the application note, here is the

Chemical structure of [3H-CP-55940]. with even more diversity in chemical structures and affinities for other receptors. If you want to read the materials and methods section check out the link  to the full article. Chem. Chem.   2006 , 49  (1), 70–79. https://doi.org/10.1021/jm050467q .

They have several advantages, such as the minimal chemical modifications in the original ligand, high Tritium (3H) labeled ligands are usually chemically identical to the original, because tritium will usually specific activity, but a shorter half-life (60 days), which complicates storage, besides changing the chemical

determined to be 30.1 ± 1.7 nM corresponding to apparent Ki ± SEM = 15.7 ± 0.9 nM according to the Cheng-Prusoff Journal of Biological Chemistry   2005 , 280 (3), 2176–2185. https://doi.org/10.1074/jbc.M410385200 Chem.   2022 , 65  (6), 4832–4853. https://doi.org/10.1021/acs.jmedchem.1c02033 . (18)      Dempsey, C.; Chen, K. H.; Bates, M.; Zhuang, X.

This is Lucía from the Celtarys Research chemistry team.  You can check what we do here on our website!   In Comprehensive Analytical Chemistry ; Verma, S. K., Das, A. Bioconjugate Chem.   2015 , 26  (1), 145–152. https://doi.org/10.1021/bc5005262 . Chem. Rev.   2008 , 108  (8), 2952–3015. https://doi.org/10.1021/cr0783479 .

Bring in a computational chemist. Add a data scientist. Surely more hands will move the needle.

That’s where computational chemistry steps in. This case study highlights why computational chemistry is no longer a side tool—it’s a driver of discovery

You’ll see how this manifests in real data from muscarinic receptors, CCR5 chemokine programs, and NMDA

GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The pace of innovation in medicinal chemistry is accelerating—and if you missed this year’s ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025 , you’re already behind.

. 🔍 This Week in Premium: Sneak Peek Industry insights:  Strategic biotech alliances (Chemspace/Enamine

He shares his journey into computational chemistry and offers a compelling look at how tools like AlphaFold

It’s about a dynamic dance of chemical forces, equilibrium shifts, and molecular decisions that determine The dynamic interplay of chemical forces shapes drug effectiveness.

Pin stayed loyal to GPCRs , even when big pharma turned its gaze to other targets like kinases and checkpoint

Plus: must-read chemokine and PTH1R papers, and new momentum across biotech—from Superluminal to Neurocrine Read The Full Article GPCR Publication Highlights   Chemokine–GPCR Selectivity Unveiled Sequence- and structure-based analysis reveals how conserved and variable regions across chemokines and their receptors

Here’s the surprising truth: up to 80% of GPCR-targeted drugs fail—not because of poor chemistry, but

Blocking this chemokine axis reduces pain  hypersensitivity by dampening neuroinflammation and glial

You’ll uncover: Why pharmacology is the glue between chemistry and biology How to interpret drug behavior

Maria Majellaro Celtarys specializes in the custom development of fluorescent ligands  using a modular chemistry But what sets them apart isn’t just chemistry. It’s empathy. Democratize access to high-performance chemical probes and make assay development faster, cheaper, and

GPCR Partner Tools The Story Behind Celtarys – From Chemistry to Company   How does a medicinal chemist

Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology “This partnership will help accelerate the adoption of our chemical tools and foster collaborations that Celtarys Research is a biotech company based in Spain that specializes in the development of optimal chemical Their proprietary chemistry platform enables rapid generation of conjugates, such as labeled ligands,

Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years

With collaborations across medicinal chemistry and neuropathic pain research, Ben is bridging molecule

Plus, check out the latest Dr. GPCR tools and key moves in the biotech world. Dr. GPCR University Cheatsheet   is your quick-start guide to everything we offer—no downloads, no digging Explore the Cheatsheet GPCR Publication Highlights   — Minimal Structural Variation of GPR84 Full Agonist

XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain Regulation of the chemokine

Hauser Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR Jun Xu , Geng Chen To fully explore our Ecosystem, scroll to the footer and check out our Map! We're about to reveal our University CheatSheet —a sneaky peek at all our talks, presentations, and courses XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry receptor probed by molecular dynamics simulations, NMR and pharmacological studies High-affinity ELR+ chemokine

🕵️‍♂️We'll soon be unveiling our University CheatSheet! Major Announcement! XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry

XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry receptor GPR68 supports AML cells through the calcium/calcineurin pro-survival pathway and confers chemoresistance obesity and skeletal muscle dysfunction via improving skeletal muscle Srl/MRCC-I pathway in Drosophila Chemogenetic

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This data can guide the modification of the chemical structure of the lead compounds to improve potency

al. for their excellent work on Receptor determinants for ß-arrestin functional specificity at C-X-C chemokine Meeting in 2025 NEW April 3 - 6, 2025 | ASPET 2025 NEW   April 14 - 17, 2025 | 20th Drug Discovery Chemistry cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry like and β2 adrenergic receptors Receptor determinants for ß-arrestin functional specificity at C-X-C chemokine receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development Chemokine