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Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr. Maria Majellaro of Celtarys shares how her team translates medicinal chemistry into practical GPCR assay

of Discovery pHSense wasn’t built in a vacuum—it was born from decades of groundwork in rare earth chemistry It’s the product of layered collaborations—with Durham University chemist David Parker on the probe chemistry

year of expert training Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount at Checkout

Seemed Like Magic Before modern pharmacology, enzymes were mysterious catalysts that seemed to defy chemical In this lecture, you’ll revisit the early days of discovery: when scientists thought cellular chemistry isn’t a checkbox; it’s a survival test. Yet many discovery teams still relegate them to the “ADME” checklist, rather than the strategic design

months of expert training Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount at Checkout updates, priority event alerts, vetted jobs, and commentary that connects dots across pharmacology, chemistry

It started not with biology—but with chemistry. Revvity and academic collaborator Prof. Mini Timeline: The Road to pHSense → Initial lanthanide probe design with Durham University (chemistry Revnity’s partnership with Durham (chemistry) and the Institute of Functional Genomics in Montpellier

Adjusting assay sensitivity—whether through expression systems, chemical modulation, or engineered desensitization—provides

GPCR members save  50%+  (check your Weekly News code). Years of chemistry, photophysics, and pharmacology condensed into one breakthrough: pHSense , a reagent Rare-earth europium complexes offered potential—but the chemistry was brutal. They translated a fundamental principle of chemistry into a usable platform for pharmacology—showing how persistence, precision, and the courage to take on “impossible” chemistry can shift the entire GPCR

GPCR members save  50%+  (check your Weekly News code).

By combining deep expertise in GPCR biology with advanced fluorescence chemistry, Celtarys custom-developed Curr Chem Genomics. 2009 May 28;3:22-32. doi: 10.2174/1875397300903010022.

Chem Rev. 2017 Jan 11;117(1):139-155. Chem Rev. 2017 Jan 11;117(1):139-155. doi: 10.1021/acs.chemrev.6b00177 Alavi MS, Shamsizadeh A, Azhdari-Zarmehri

Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount at Checkout ➤ Revvity x Dr scientists actually need—and validating it where it counts. 🎧 Go behind the scenes with Revvity —from the chemistry

Here’s who we've talked to so far: 🎥 Check out the interview with Dr. from UNC and Terry's Corner We'll continue to update this section as new videos are released — so check

Unlock real SAR:  Deconvolute potency into affinity vs. efficacy to make medicinal chemistry cycles more

Internal checks (like requiring a Schild regression slope of unity for competitive antagonism) add further Chemists suddenly have meaningful levers to pull. The lesson: models don’t just need data. shifted curves left Sometimes it raised baseline activity Sometimes it boosted the maximum response Chemists

Must-read publications:  A structural modeling study revealing non-canonical mechanisms of chemokine-driven

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Axxam’s capabilities span the full spectrum of GPCR families, including aminergic, peptide, lipid, and chemosensory

Adapted from: Zhang Y, Tang H, Chen W, Zhang J. ACS Med Chem Lett. 2022 Jan 10;13(2):243-249. doi: 10.1021/acsmedchemlett.1c00598.

ACS Chem Biol. 2014 Sep 19;9(9):1918-28. doi: 10.1021/cb5004042. 

If you want to check out the Materials and Methods section as well as the application note, here is the

Chemical structure of [3H-CP-55940]. with even more diversity in chemical structures and affinities for other receptors. If you want to read the materials and methods section check out the link  to the full article. Chem. Chem.   2006 , 49  (1), 70–79. https://doi.org/10.1021/jm050467q .

They have several advantages, such as the minimal chemical modifications in the original ligand, high Tritium (3H) labeled ligands are usually chemically identical to the original, because tritium will usually specific activity, but a shorter half-life (60 days), which complicates storage, besides changing the chemical

determined to be 30.1 ± 1.7 nM corresponding to apparent Ki ± SEM = 15.7 ± 0.9 nM according to the Cheng-Prusoff Journal of Biological Chemistry   2005 , 280 (3), 2176–2185. https://doi.org/10.1074/jbc.M410385200 Chem.   2022 , 65  (6), 4832–4853. https://doi.org/10.1021/acs.jmedchem.1c02033 . (18)      Dempsey, C.; Chen, K. H.; Bates, M.; Zhuang, X.

This is Lucía from the Celtarys Research chemistry team.  You can check what we do here on our website!   In Comprehensive Analytical Chemistry ; Verma, S. K., Das, A. Bioconjugate Chem.   2015 , 26  (1), 145–152. https://doi.org/10.1021/bc5005262 . Chem. Rev.   2008 , 108  (8), 2952–3015. https://doi.org/10.1021/cr0783479 .

Bring in a computational chemist. Add a data scientist. Surely more hands will move the needle.

That’s where computational chemistry steps in. This case study highlights why computational chemistry is no longer a side tool—it’s a driver of discovery

You’ll see how this manifests in real data from muscarinic receptors, CCR5 chemokine programs, and NMDA

GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The pace of innovation in medicinal chemistry is accelerating—and if you missed this year’s ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025 , you’re already behind.

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