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Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount at Checkout ➤ Revvity x Dr scientists actually need—and validating it where it counts. 🎧 Go behind the scenes with Revvity —from the chemistry

Here’s who we've talked to so far: 🎥 Check out the interview with Dr. from UNC and Terry's Corner We'll continue to update this section as new videos are released — so check

Unlock real SAR:  Deconvolute potency into affinity vs. efficacy to make medicinal chemistry cycles more

Internal checks (like requiring a Schild regression slope of unity for competitive antagonism) add further Chemists suddenly have meaningful levers to pull. The lesson: models don’t just need data. shifted curves left Sometimes it raised baseline activity Sometimes it boosted the maximum response Chemists

Must-read publications:  A structural modeling study revealing non-canonical mechanisms of chemokine-driven

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Axxam’s capabilities span the full spectrum of GPCR families, including aminergic, peptide, lipid, and chemosensory

Adapted from: Zhang Y, Tang H, Chen W, Zhang J. ACS Med Chem Lett. 2022 Jan 10;13(2):243-249. doi: 10.1021/acsmedchemlett.1c00598.

ACS Chem Biol. 2014 Sep 19;9(9):1918-28. doi: 10.1021/cb5004042. 

If you want to check out the Materials and Methods section as well as the application note, here is the

Chemical structure of [3H-CP-55940]. with even more diversity in chemical structures and affinities for other receptors. If you want to read the materials and methods section check out the link  to the full article. Chem. Chem.   2006 , 49  (1), 70–79. https://doi.org/10.1021/jm050467q .

They have several advantages, such as the minimal chemical modifications in the original ligand, high Tritium (3H) labeled ligands are usually chemically identical to the original, because tritium will usually specific activity, but a shorter half-life (60 days), which complicates storage, besides changing the chemical

determined to be 30.1 ± 1.7 nM corresponding to apparent Ki ± SEM = 15.7 ± 0.9 nM according to the Cheng-Prusoff Journal of Biological Chemistry   2005 , 280 (3), 2176–2185. https://doi.org/10.1074/jbc.M410385200 Chem.   2022 , 65  (6), 4832–4853. https://doi.org/10.1021/acs.jmedchem.1c02033 . (18)      Dempsey, C.; Chen, K. H.; Bates, M.; Zhuang, X.

This is Lucía from the Celtarys Research chemistry team.  You can check what we do here on our website!   In Comprehensive Analytical Chemistry ; Verma, S. K., Das, A. Bioconjugate Chem.   2015 , 26  (1), 145–152. https://doi.org/10.1021/bc5005262 . Chem. Rev.   2008 , 108  (8), 2952–3015. https://doi.org/10.1021/cr0783479 .

Bring in a computational chemist. Add a data scientist. Surely more hands will move the needle.

That’s where computational chemistry steps in. This case study highlights why computational chemistry is no longer a side tool—it’s a driver of discovery

You’ll see how this manifests in real data from muscarinic receptors, CCR5 chemokine programs, and NMDA

GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The pace of innovation in medicinal chemistry is accelerating—and if you missed this year’s ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025 , you’re already behind.

. 🔍 This Week in Premium: Sneak Peek Industry insights:  Strategic biotech alliances (Chemspace/Enamine

He shares his journey into computational chemistry and offers a compelling look at how tools like AlphaFold

It’s about a dynamic dance of chemical forces, equilibrium shifts, and molecular decisions that determine The dynamic interplay of chemical forces shapes drug effectiveness.

Pin stayed loyal to GPCRs , even when big pharma turned its gaze to other targets like kinases and checkpoint

Plus: must-read chemokine and PTH1R papers, and new momentum across biotech—from Superluminal to Neurocrine Read The Full Article GPCR Publication Highlights   Chemokine–GPCR Selectivity Unveiled Sequence- and structure-based analysis reveals how conserved and variable regions across chemokines and their receptors

Here’s the surprising truth: up to 80% of GPCR-targeted drugs fail—not because of poor chemistry, but

Blocking this chemokine axis reduces pain  hypersensitivity by dampening neuroinflammation and glial

You’ll uncover: Why pharmacology is the glue between chemistry and biology How to interpret drug behavior

Maria Majellaro Celtarys specializes in the custom development of fluorescent ligands  using a modular chemistry But what sets them apart isn’t just chemistry. It’s empathy. Democratize access to high-performance chemical probes and make assay development faster, cheaper, and

GPCR Partner Tools The Story Behind Celtarys – From Chemistry to Company   How does a medicinal chemist

Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology “This partnership will help accelerate the adoption of our chemical tools and foster collaborations that Celtarys Research is a biotech company based in Spain that specializes in the development of optimal chemical Their proprietary chemistry platform enables rapid generation of conjugates, such as labeled ligands,

Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years