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generating data when experiments are working smoothly, but neglecting to analyze that data in real-time Procrastination may seem tempting, but tackling your work incrementally will save time and reduce stress

Instead of dreading lab time, she found herself chasing questions late into the night. By understanding how signaling is organized in time and space, her team is opening doors to next-generation

photometry with FRET-based biosensors, we were able to track GPCR-dependent signaling pathways over time weeks to allow biosensor expression, fiber photometry is used in order to record drug responses in real time

In this study, for the first time, we demonstrate the nuclear localization of H2R in lymphatic endothelial At the same time, H2R as a GPCR imparts many unresolved questions, such as the functional relevance of

This has direct implications for: Assay timing and readout design Misclassification of lead candidates walk away with tools to: Interpret probe-dependent effects Model and anticipate longer equilibration times

And by the time you catch it, your burn rate is up and your traction is down. By the time it surfaces, you’ve lost two months of budget and alignment. 2️⃣ Milestone redefinition slowly redirects energy, delays clarity, and erodes momentum. 👉 You don’t notice it until you’re out of time

It’s a simple way to share valuable resources and support the field—one connection at a time.  

While others refined lab techniques, he found himself gravitating toward structural models in his spare time It was the first time he found himself immersed in a computational environment, and he realized how much At the time, there were no solved structures of GPCRs readily available, so his work remained disconnected

hinges on where receptors actually are, how they internalize, and how tissues interpret signals in real time For those who prefer to contribute outside of membership, one-time or recurring donations  also ensure

aims to investigate the possible role of FSH excess in male bone health, by comparing for the first time

was graduate student Emily Lorenzen  who helped frame the next step: stop studying one receptor at a time

favorite design, spark conversations in the lab, and help power everything we build—one mug or hoodie at a time

It was the first time late nights in the lab weren’t a burden but a sign of genuine engagement. Why Catherine Chose Academia At a time when many early-career scientists debate whether to stay in academia

March 2022 "February 17, 2022 08:00 AM Eastern Standard Time SAN FRANCISCO & SHANGHAI- ShouTi Inc., a

What you’ll learn: Reveal cryptic binding sites and time-dependent interactions.   Map dynamic receptor behavior to real-time decision-making.  

from the Inside Out Now back in med school, Serafini aims to follow the physician-scientist path: part-time

DVT formation is a time-dependent inflammatory process in which NETosis plays an important role.

Eric Trinquet joined Cisbio in the early 2000s, working on what would become HTRF—Homogeneous Time-Resolved You’ll fail 90% of the time.

This time with none other than Dr. Bryan Roth There are 10 open tickets available. Get yours now!

A powerful three-color approach captures dynamic receptor states in real time.

—Alessandro Nicoli For the first time, researchers had a reliable set of predicted structures to work

In rodents, intrathecal injection of its ligand, 7α,25-dihydroxycholesterol (7α,25-OHC), causes time-dependent Non-biased transcriptomic analyses of dorsal-horn spinal cord (DH-SC) tissues harvested at the time of

July 2022 "July 19, 2022 07:00 AM Eastern Daylight Time BOSTON--Tectonic Therapeutic, Inc. a pre-clinical

Terry’s Corner gives you timeless and timely tools to improve selectivity, model efficacy, and design

fluorescent ligands for this are: Live-cell imaging:  receptor-ligand interactions can be visualized in real-time alternative to screening In the context of CNS drug development, where receptor localization and real-time

process kinetics is useful from multiple points of view – practically, it can be used to determine the time Figure 1.Time course of FA change caused by CELT-419 binding to D3 receptor on the BBV particles. The speed of reaching the binding equilibrium is key for this assay, which can be monitored over time The insert shows the Log(IC50) ± SE change in time of corresponding displacement curves. The Log(IC50) change in time was fitted with equation  3  and k given is the weighted average from 3 

Terry’s Corner: Why Binding Kinetics Matter More Than Affinity In drug discovery today, time wasted is Stay focused, informed, and ahead of your competitors while saving critical time each week. Dr.

Methods: Immunohistochemistry, western blot and quantitative real-time PCR techniques were used to analyze

In this study, we found, for the first time, that the expression of GPR110 increased during osteoclastogenesis

Pipeline Payoff: Assay Sensitivity for Better Predictions For drug discovery scientists, time and predictive Every mischaracterized compound that enters animal studies or early trials is a tax on time and resources