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Learning the Lab, Learning Herself During her time at the contract research organization (CRO) in Ann that would reshape her academic ambitions. “...I had a light bulb moment where I felt for the first time For the first time, she saw herself as a future researcher, not just a technician or a student.

Separate effect size from time:  Use allosteric modulators to expand therapeutic index and reduce overdose The Advantages Live-cell imaging:  visualize receptor–ligand interactions in real time, without disturbing Why It Matters In the CNS, where receptor localization and real-time signaling shape therapeutic outcomes Access this week’s full Premium Edition here ➤ What our members say "This came at just the most perfect time

GPCR Premium Members a significantly reduced access  to Terry's Corner for a limited time.  

Whether you're stepping into pharmacology for the first time or rekindling your interest, this lesson

Real-Time Global Insight As founder of Dr. Even strong science stalls without operational structure ✅ Scattered data = missed insights = wasted time

positions, tailor activity (agonist or antagonist), and retain biological function, all while skipping the time-consuming

Watch Episode 166 When’s the last time you argued in the lab about injecting GTPγS?

If you aren't joining us this time, stay tuned for more Dr. GPCR University content coming soon.

generating data when experiments are working smoothly, but neglecting to analyze that data in real-time Procrastination may seem tempting, but tackling your work incrementally will save time and reduce stress

Instead of dreading lab time, she found herself chasing questions late into the night. By understanding how signaling is organized in time and space, her team is opening doors to next-generation

photometry with FRET-based biosensors, we were able to track GPCR-dependent signaling pathways over time weeks to allow biosensor expression, fiber photometry is used in order to record drug responses in real time

In this study, for the first time, we demonstrate the nuclear localization of H2R in lymphatic endothelial At the same time, H2R as a GPCR imparts many unresolved questions, such as the functional relevance of

This has direct implications for: Assay timing and readout design Misclassification of lead candidates walk away with tools to: Interpret probe-dependent effects Model and anticipate longer equilibration times

And by the time you catch it, your burn rate is up and your traction is down. By the time it surfaces, you’ve lost two months of budget and alignment. 2️⃣ Milestone redefinition slowly redirects energy, delays clarity, and erodes momentum. 👉 You don’t notice it until you’re out of time

They chase direction, intent, and timing. In practice, founders overestimate how much time they have, usually by several months.

While others refined lab techniques, he found himself gravitating toward structural models in his spare time It was the first time he found himself immersed in a computational environment, and he realized how much At the time, there were no solved structures of GPCRs readily available, so his work remained disconnected

It’s a simple way to share valuable resources and support the field—one connection at a time.  

hinges on where receptors actually are, how they internalize, and how tissues interpret signals in real time For those who prefer to contribute outside of membership, one-time or recurring donations  also ensure

aims to investigate the possible role of FSH excess in male bone health, by comparing for the first time

was graduate student Emily Lorenzen  who helped frame the next step: stop studying one receptor at a time

favorite design, spark conversations in the lab, and help power everything we build—one mug or hoodie at a time

It was the first time late nights in the lab weren’t a burden but a sign of genuine engagement. Why Catherine Chose Academia At a time when many early-career scientists debate whether to stay in academia

What you’ll learn: Reveal cryptic binding sites and time-dependent interactions.   Map dynamic receptor behavior to real-time decision-making.  

March 2022 "February 17, 2022 08:00 AM Eastern Standard Time SAN FRANCISCO & SHANGHAI- ShouTi Inc., a

from the Inside Out Now back in med school, Serafini aims to follow the physician-scientist path: part-time

Eric Trinquet joined Cisbio in the early 2000s, working on what would become HTRF—Homogeneous Time-Resolved You’ll fail 90% of the time.

DVT formation is a time-dependent inflammatory process in which NETosis plays an important role.

—Alessandro Nicoli For the first time, researchers had a reliable set of predicted structures to work

A powerful three-color approach captures dynamic receptor states in real time.

In rodents, intrathecal injection of its ligand, 7α,25-dihydroxycholesterol (7α,25-OHC), causes time-dependent Non-biased transcriptomic analyses of dorsal-horn spinal cord (DH-SC) tissues harvested at the time of