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In this session, you’ll gain: ✅ A deeper understanding of how every ligand alters receptor conformation—and Subscribers gain access to: Weekly lessons by Dr.

A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice.

inhibits purinergic P2Y2 receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain

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Activation and Signaling Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain

Watch the trailer 👇 What you’ll gain Validate the model behind the data.   You also gain access to member-only discounts, full GPCR University content, and an integrated view of

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receptor Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain

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modulate protein-protein interactions; and also by the presence of the GPCR-Autoproteolysis INducing (GAIN endoplasmic reticulum, many of these receptors are cleaved at the GPCR Proteolysis Site motif of the GAIN When I started studying aGPCRs, the structural conformation of the GAIN domain of ADGRL1/Lphn1 and ADGRB3 These crystal structures showed how the Stalk region, which is a short peptide released from the GAIN during auto-proteolysis, has a β-lamin conformation and is held within the GAIN surrounded by numerous

In this lesson, you’ll gain: A strategic view of how chemical scaffolds shape pharmacologic outcomes Subscribers gain weekly lectures led by Dr.

Identification of a potential structure-based GPCR drug for interstitial cystitis/bladder pain syndrome

In this session, you'll gain: ✅ Tools to confirm true equilibrium and avoid potency errors from premature If you detect it, you gain texture that equilibrium constants alone can’t provide.

The main challenge was simple but daunting: “The challenge was to get a face to those proteins—the structure

After excelling in the PCAT and gaining admission to pharmacy school at the University of Michigan, it that environment, every project brought new challenges—deadlines, documentation, and deliverables for paying She gained exposure to in vivo models, immunology, and complex study design, while also getting closer

Adhesion GPCRs Piconewton Forces Mediate GAIN Domain Dissociation of the Latrophilin-3 Adhesion GPCR Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs GPCR Activation

patients with severe, active granulomatosis polyangiitis (GPA) or microscopic polyangiitis (MPA), the two main

It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of

transcriptional responses and contribute to physiological processes such as meiosis in ovarian follicles and pain

A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved

You'll gain valuable insights into the critical role binding plays in pharmacology.

Nanobodies have gained traction rapidly due to their biochemical tractability and their ability to recognize

Moreover, the main investigations into animal models and ongoing clinical trials using these unimolecular

programs in key therapeutic areas Kallyope, pioneers in drug discovery involving the gut-brain axis, will gain

Scientist, Computational Chemistry Postdoc in GPCR mechanosensing   GPCR Activation and Signaling A gain

Tobias Langenhan for his papers to highlight suggestions GAIN Domain Unfolding in Adhesion GPCRs Molecular ADGRE2 to Circulating Neutrophils Is Not Related to Injury Severity Unveiling Mechanical Activation: GAIN

In this session, you’ll gain: ✅ A clear map of how drugs interact with enzymes before, during, and after Through stories, such as how ethanol competes with methanol in cases of poisoning, you can gain insight