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we explore how computational tools—especially AlphaFold —are helping crack the mystery of olfactory GPCRs The Problem: Hundreds of Receptors, Almost No Ligands Alessandro’s work focuses on olfactory GPCRs—nearly : Predicting the “Face” of a Receptor When Alessandro began his PhD, structural models of olfactory GPCRs —Alessandro Nicoli A New Era of GPCR Research AlphaFold didn’t just fill a gap—it shifted the focus of Start with our GPCR training program and get hands-on with virtual tools shaping the future of drug discovery

function and expression landscape Odorant receptors (ORs) belong to the G protein-coupled receptor (GPCR OR51E1 and OR51E2, initially assumed to be GPCRs only expressed in prostate tissue, play a role in prostate of GPCRs. expression of ORs is generally more technically challenging compared with expression of nonolfactory GPCRs Check the original article at https://pubmed.ncbi.nlm.nih.gov/35999088/ #GPCR #DrGPCR#Ecosystem

Yamina’s Corner delivers GPCR consulting that cuts through the noise, designing assay cascades, setting GPCR partner Celtarys Research has validated a TR-FRET assay for cannabinoid receptor ligands using their Read The Full Article GPCR Publication Highlights   Chemokine–GPCR Selectivity Unveiled Sequence- and Distinct Ligand Activation in NMBR Simulations show how two ligands differently activate class A GPCR GPCR Team Join Our Newsletter!

A single successful GPCR imaging experiment can transform a project’s trajectory. Interdisciplinary design isn’t optional in GPCR imaging. It’s the catalyst. And the most striking validation came from in vivo GPCR imaging. Strong GPCR imaging tools come from strong interdisciplinary relationships.  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs Using current knowledge on class A GPCRs and existing experimental data in the literature as constraints

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target In accelerating GPCR drug discovery, the bottleneck isn’t target identification — it’s turning validated GPCR Kinetics: The Critical Data You Can’t Afford to Skip Equilibrium potency data only tells part of “GPCRs are nature’s prototype allosteric proteins. Everything they do is allosteric.” Kenakin with your own enzyme or GPCR interaction puzzles.

Enhance your GPCR research with deeper assay insights for more effective results. This Week’s GPCR Intelligence: If you want cleaner decisions, start with the system—then the ligand. Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates allosteric site on an orphan GPCR. 🔍 This Week in Dr. GPCR innovation is accelerating.

GPCR Premium: Sneak Peek Want the full classified brief? GPCR , our mission is simple but urgent: Accelerate GPCR biology and drug discovery by connecting scientists GPCR Podcast, the Revvity team built pHSense™ from the ground up by listening to what GPCR scientists GPCR innovation is accelerating. GPCR and the offered resources in my work sphere." — DrGPCR University Attendee GPCR innovation doesn

What does DNA Day have to do with GPCRs? GPCR biology, the development of GPCR-targeted drugs, and the exploration of GPCRs as key regulators in the total count of GPCR genes in the human genome. The genetic variation in GPCRs is extensive; databases like GPCRdb provide a large database of genetic Structural bioinformatics analysis of variants on GPCR function.

Kenakin  highlighted a fundamental truth: GPCR systems do not offer stable, proportional input–output Teams equipped with deep GPCR pharmacology insights make different decisions. The sections below synthesize the key topics addressed during the AMA and highlight the GPCR pharmacology This is a core GPCR pharmacology insight:ligand → receptor → G protein is never the entire story. GPCR innovation is accelerating, and those who invest in deeper GPCR pharmacology insights today will

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already Upcoming events:  GPCR-UK Network Meeting, neuroGPCR symposium, and Transatlantic ECI GPCR event—where GPCR Podcast Listener Why Dr. GPCR Premium 🔹 What’s included? The pace of GPCR innovation is accelerating.

For drug hunters working at the GPCR interface, the difference between a successful lead and a dead-end For GPCR drug discovery, those hidden details can determine whether a compound advances or stalls. The Hidden Lever in GPCR Research In GPCR pharmacology, the conversation often centers on ligand properties—affinity In an era of accelerated GPCR-targeting innovation, these advantages define which programs advance and GPCR members save 50%+ with your Weekly News code) 👉   Explore Trailers & Join Today Why Terry’s Corner

GPCR signaling almost never follows a straight path. This article is about one big idea: GPCRs don’t act in isolation—they respond to the system they’re in In this session, you’ll gain: ✅ A mental model you can trust  for predicting how GPCR ligands behave Internalized Signaling: Same Receptor, Different Story A GPCR response isn’t always over when the receptor Constitutive Activity: When Doing Nothing Still Does Something Some GPCRs simply refuse to stay quiet

Terry’s Corner: GPCR Binding Affinity Experiments That Hold Up Orthosteric GPCR binding affinity experiments GPCR Podcast: When GPCR Tools Scale Even the most elegant tools only matter when they scale beyond a GPCR Year in Review: Carrying Better Experiments Into 2026 As 2025 closes, the Dr. GPCR offers a clear signal of where the field is heading. GPCR Premium Member And Lock in The Current Rate➤ https://www.ecosystem.drgpcr.com/gpcr-university-pricing

Elevate Your GPCR Science with Essential Frameworks for Precision Drug Discovery: An Insight into Advanced GPCR-Based Drug Discovery conference is where the future of GPCR therapies will be defined. GPCR Premium Membership Gives You an Edge In a world filled with noise, Dr. GPCR Premium Membership delivers curated, noise-free intelligence every week. The pace of GPCR innovation is accelerating.

High-content screening (HCS) has become a cornerstone in GPCR and phenotypic drug discovery, enabling For GPCR-focused programs, the ability to visualize receptor localization, internalization kinetics, In this blog, you’ll learn:  How HCS works and why it is increasingly central to GPCR-based drug discovery The resulting multiparametric datasets are well-suited for GPCR research, where receptor trafficking, For GPCR assay developers, HCS supports:  Quantitative visualization of receptor internalization and

significant attention in drug discovery, especially in the context of G protein-coupled receptors (GPCRs The GLP-1R, a class B1 GPCR, is integral to metabolic regulation, particularly in glucose homeostasis the obesity market toward $66 billion by 2030 and on track to become one of the most lucrative drug classes Cary, B.P., et al., New Insights into the Structure and Function of Class B1 GPCRs.  

Drum rolls, we’ve got 15 GPCR research papers, updates, industry news events, and GPCR ads curated just GPCR University Exciting news! GPCR Event Highlight Get ready for the 11th Adhesion GPCR Workshop! GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs GPCR Ecosystem

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

But for Ajay Yekkirala, that closed door lit the fuse for a career that would reimagine GPCR therapeutics Blue Therapeutics: Turning GPCR Biology Into a Business Ajay’s academic training planted the seeds for The goal of Blue wasn’t just to publish or patent; it was to bring a novel, safer class of pain therapeutics Superluminal Medicines: AI/ML Meets GPCR Pharmacology As Ajay continued to explore how GPCR signaling Takeaway: Ajay Yekkirala’s story is not just about GPCR science or startup success.

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. Hi GPCR Community, If equilibrium curves are your comfort zone, this week’s feature will challenge (and GPCR Premium: Sneak Peek Here’s a fast, high-level preview of what Premium Members are unpacking this We’ve got your GPCR Track, Happy Hour, and sessions mapped so you can extract maximum value. GPCR innovation is accelerating.

Fluorescent probes illuminate the mysteries of GPCRs in cutting-edge research. Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing GPCR Premium: Sneak Peek A fast, editorial preview—enough to guide your attention, not replace your due Track, GPCR Happy Hour, and more! GPCR innovation is accelerating.

Welcome to the 4th official Adhesion GPCR Consortium newsletter! de Investigación y de Estudios Avanzados del IPN (Cinvestav) How did you become involved in adhesion GPCR AB: I became aware of the existence of adhesion GPCRs while completing my graduate studies. The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their AB: The next workshop will likely bring together some of the hottest adhesion GPCR research going on

GPCR research requires turning data into insights for drug discovery Hi GPCR Friends, Every week, critical decisions in GPCR research hinge on subtle shifts in data. GPCR Podcast – Ajay Yekkirala on GPCR Innovation In this episode, Dr. Be part of the nonprofit mission to unite the GPCR community. The pace of GPCR innovation is accelerating.

Watch Episode 167 Some GPCR-targeting antibodies don’t inhibit receptors. They activate them. GPCRs, are likely targets for antibody-based immune responses. This is the future of GPCR immunology . ________________ Keyword Cloud : GPCR autoantibodies , GPCR immunology , GPCR diagnostics , Dr. GPCR ecosystem , multiplex assays

GPCR and global experts at the GPCR Drug Discovery session during Discovery on Target 2025—where groundbreaking GPCR Is in This Conversation At Dr. GPCR , our mission is simple: connect the GPCR community, share knowledge, and accelerate innovation . 🚀 Why GPCRs Are Still the Hottest Target Class in Drug Discovery GPCRs regulate countless physiological Let’s move GPCR drug discovery forward — together. 🚨 Mark your calendar for the GPCR Happy Hour Join

October 2022 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental Among them, the secretin/adhesion (Class B) G protein-coupled receptors are essential drug targets for Given the great value of the secretin/adhesion (Class B) G protein-coupled receptors in the regulation Read more at the source #DrGPCR #GPCR #IndustryNews

explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini Takeaway Forget what you think you know about GPCR drug targets. data platform , GPCR training program , pain research , opioid signaling .

Research Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Receptor Reviews, GPCRs, and more Life, death and resurrection of plant GPCRs Structural Papers GPCRs: Signal Transduction. GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. GPCR Ecosystem

Traditionally, GPCR signaling was believed to primarily occur at the plasma membrane. GPCRs have also been identified within the mitochondria. Compartmentalized GPCR Signaling from Intracellular Membranes. Functional selectivity of GPCR-directed drug action through location bias. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic