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We have explored hydrophobic groups of different sizes on both sides of the five-membered ring scaffold

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in

Although the high-resolution crystal structures of the DOR with both agonist and antagonist have recently

Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients

Kenakin dissects how P450s can be both protective and problematic. Each mode reshapes both potency and therapeutic window.

sites of N-acetyl galactosamine (GalNAc)-type O-glycosylation in their N-termini as well as sulfation, both Both PTMs were shown to contribute to the binding of CCL5 and CCL8 and to a minor extend CCL3. The combined effects of both PTMs as well as the relevance of specific acceptor sites and glycan composition

This is also where Gq/Gs bind the receptor through both hydrophobic and polar interaction, while Gi/G12

In the experiment, similar sets of residues were found to be in significant contact with both ligands

domain 1 (FnIII.1) suggest the cysteine-rich (CR) and the FnIII.1 domains could assist the WAP domain both

discussed that one should consider when attempting to compare functional outcomes from different studies, both

Meanwhile, the antagonist ligands made interactions with W2866.48×48 and Y3167.43×42, both residues considered

Both PAR4 and PAR2 are able to drive the association of methyltransferase EZH2 with β-catenin, culminating

Since we cover both the theoretical as well as practical aspect of these topics, the platform addresses

By carefully tuning both brightness and fluorescence lifetime, they engineered a two-dimensional pH response receptor localization and real-time signaling shape therapeutic outcomes, fluorescent ligands deliver both

Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both

Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717,

interactome includes numerous proteins which interact with differential domains of GRK2 to modulate both

the N-loop determines the subfamily-specific arrangement of the distal N-terminus and the 30s-loop, both By examining both the active and inactive states of CCR5, it becomes evident that there are four distinct Constitutive Activity of the viral CKR US28 and “Chemokine Scavenger” ACKR3 Both US28 and ACKR3 are constitutively Experimental 3D structures of both receptors reveal that they employ distinct mechanisms for constitutive

evident increase in SRE-luc activity was noticed when COS-7 cells expressing GnIHR were challenged with both

Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in both

In CRPC xenografts, antagonizing AVPR2, AVPR1A, or both significantly reduced CRPC tumor growth as well

Not possible when nothing’s built to surface the right  insights early.

In vivo, suppression of postsynaptic cAMP signaling in CA1 neurons prevented formation of both Schaffer-collateral

Our earlier reports suggested that GPR3 enhances both neurite outgrowth and neuronal survival.

reports demonstrated that Fgr exhibits high constitutive activity, but can be further activated by both

The data support the inference that they act at the active interface between both transmembrane domains

influence the orthosteric binding pocket, potentially altering the rate of association, dissociation, or both On the other hand, selectivity could be achieved by merging both orthosteric and allosteric pharmacophores

At the synapse, they are localized in both pre- and postsynaptic compartments and their activation is The authors found that both β-arrestin 1 and 2 are involved in MOR internalization and downstream signaling

In this review, we outline some key NMR techniques applied for on-cell NMR studies through both solution

however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both