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Instead, fast calcium signals in PFC astrocytes are time locked to dopamine release and are mediated

fluorescence, electrochemiluminescence, fluorescence emission, immunofluorescence staining, HTRF (homogeneous time-resolved fluorescence), and TR-FRET (time-resolved fluorescence resonance energy transfer).

Commercialization of Ultrahigh Throughput Drug Discovery Platform "April 12, 2022 07:00 AM Eastern Daylight Time

Real-time calcium activity. Signaling waves pulsing across clusters of beta cells. Instead of testing one compound at a time, they evaluated multiple probes in the same experimental conditions

conformational changes that occur during G-protein activation by the β2-adrenergic receptor, using a time-resolved Time-resolved cryo-EM of G protein activation by a GPCR. bioRxiv : the preprint server for biology, 2023.03.20.533387

M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka, Georgios Skiniotis, et al. for their research on Time-resolved transport of nascent G protein-coupled receptors Structural and Molecular Insights into GPCR Function Time-resolved

January 2022 "Voltaire argued, “Perfection is attained by slow degrees; it requires the hand of time.

We then mapped the 394 GPCR X-ray structures available at the time of the analysis (September 2020).

In 2008 (and for the first time in the clinic), the therapeutic benefits of the β-adrenergic receptor

The development of molecular tools to study GPCR trafficking in real-time opens new avenues for understanding

Time-dependent inhibition adds another nonlinear dimension: once the enzyme is trapped, recovery depends Strategic considerations: CYP time-dependent inactivation is mechanistically distinct from GPCR irreversibility

This time, the GPCRdb team ( Dr. David Gloriam , Dr.

For those who joined any of our symposium sessions, we kindly request a moment of your time to fill out – our premium members have continuous access to revisit and watch the archived presentations at any time

Here, we show for the first time that MRP3 expression is induced under hypoxia through the A2B adenosine

Topics: New cellular assays, real-time kinetics, and unique GPCR behaviors. 🔥 Why You Should Enroll But act fast – this offer is only available for a limited time. Not a premium member yet?

The GloSensor™ cAMP assay enables real-time monitoring of signaling downstream of many GPCRs.

Hannes Schihada and his lab team developed fluorescent analogues for real-time binding studies of orphan primary cultures of osteoblasts and osteoclasts Development of Fluorescent AF64394 Analogues Enables Real-Time

Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling

Delve into new cellular assays, real-time kinetics, and unique GPCR behaviors. 🔥 Why You Should Enroll Premium members can enjoy a 25% OFF early bird discount , but hurry - it's only available for a limited time

Event Details 📍 Location:  Pressed Cafe on Huntington Ave in Boston 📅 Date:  September 24, 2025 ⏰ Time

This timely meeting will not only provide an inclusive forum for communication, but also a platform for

expression patterns of these 98 genes in various larval tissues were evaluated using quantitative real-time

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cellular assays to analyze GPCR ligand behavior Predicting activity and in vivo target coverage with real-time

cardiac drug development GPCRs in Neuroscience Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time

high-affinity radioligands, but with the development of potent fluorescent probes, this gap can filled in a timely

signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB)) were analyzed at different time

Timing, leadership alignment, and a critical mass of motivated scientists converged.

For the first time, a team demonstrated high-throughput internalization data in physiologically relevant

internalize both receptors whereas pasireotide promoted robust receptor internalization at shorter times