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This time with none other than Dr. Bryan Roth There are 10 open tickets available. Get yours now!

Terry’s Corner gives you timeless and timely tools to improve selectivity, model efficacy, and design

July 2022 "July 19, 2022 07:00 AM Eastern Daylight Time BOSTON--Tectonic Therapeutic, Inc. a pre-clinical

fluorescent ligands for this are: Live-cell imaging:  receptor-ligand interactions can be visualized in real-time alternative to screening In the context of CNS drug development, where receptor localization and real-time

process kinetics is useful from multiple points of view – practically, it can be used to determine the time Figure 1.Time course of FA change caused by CELT-419 binding to D3 receptor on the BBV particles. The speed of reaching the binding equilibrium is key for this assay, which can be monitored over time The insert shows the Log(IC50) ± SE change in time of corresponding displacement curves. The Log(IC50) change in time was fitted with equation  3  and k given is the weighted average from 3 

Terry’s Corner: Why Binding Kinetics Matter More Than Affinity In drug discovery today, time wasted is Stay focused, informed, and ahead of your competitors while saving critical time each week. Dr.

Methods: Immunohistochemistry, western blot and quantitative real-time PCR techniques were used to analyze

Pipeline Payoff: Assay Sensitivity for Better Predictions For drug discovery scientists, time and predictive Every mischaracterized compound that enters animal studies or early trials is a tax on time and resources

In this study, we found, for the first time, that the expression of GPR110 increased during osteoclastogenesis

Instead, fast calcium signals in PFC astrocytes are time locked to dopamine release and are mediated

fluorescence, electrochemiluminescence, fluorescence emission, immunofluorescence staining, HTRF (homogeneous time-resolved fluorescence), and TR-FRET (time-resolved fluorescence resonance energy transfer).

Real-time calcium activity. Signaling waves pulsing across clusters of beta cells. Instead of testing one compound at a time, they evaluated multiple probes in the same experimental conditions

conformational changes that occur during G-protein activation by the β2-adrenergic receptor, using a time-resolved Time-resolved cryo-EM of G protein activation by a GPCR. bioRxiv : the preprint server for biology, 2023.03.20.533387

Commercialization of Ultrahigh Throughput Drug Discovery Platform "April 12, 2022 07:00 AM Eastern Daylight Time

M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka, Georgios Skiniotis, et al. for their research on Time-resolved transport of nascent G protein-coupled receptors Structural and Molecular Insights into GPCR Function Time-resolved

January 2022 "Voltaire argued, “Perfection is attained by slow degrees; it requires the hand of time.

We then mapped the 394 GPCR X-ray structures available at the time of the analysis (September 2020).

Time-dependent inhibition adds another nonlinear dimension: once the enzyme is trapped, recovery depends Strategic considerations: CYP time-dependent inactivation is mechanistically distinct from GPCR irreversibility

The development of molecular tools to study GPCR trafficking in real-time opens new avenues for understanding

In 2008 (and for the first time in the clinic), the therapeutic benefits of the β-adrenergic receptor

For those who joined any of our symposium sessions, we kindly request a moment of your time to fill out – our premium members have continuous access to revisit and watch the archived presentations at any time

This time, the GPCRdb team ( Dr. David Gloriam , Dr.

Here, we show for the first time that MRP3 expression is induced under hypoxia through the A2B adenosine

Topics: New cellular assays, real-time kinetics, and unique GPCR behaviors. 🔥 Why You Should Enroll But act fast – this offer is only available for a limited time. Not a premium member yet?

Hannes Schihada and his lab team developed fluorescent analogues for real-time binding studies of orphan primary cultures of osteoblasts and osteoclasts Development of Fluorescent AF64394 Analogues Enables Real-Time

The GloSensor™ cAMP assay enables real-time monitoring of signaling downstream of many GPCRs.

Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling

Event Details 📍 Location:  Pressed Cafe on Huntington Ave in Boston 📅 Date:  September 24, 2025 ⏰ Time

Delve into new cellular assays, real-time kinetics, and unique GPCR behaviors. 🔥 Why You Should Enroll Premium members can enjoy a 25% OFF early bird discount , but hurry - it's only available for a limited time

This timely meeting will not only provide an inclusive forum for communication, but also a platform for