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If you're navigating a stuck GPCR program, planning your next crucial milestone, or struggling to gain

also known to be capable of self-activation via an autoproteolysis process that removes the inhibitory GAIN

The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system

perception, and thought, and have the activation of serotonin (5-HT) 2A receptors (5-HT2A Rs) as a main

The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system

First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain A.; Bazin, H.; Tinel, N.; Durroux, T.; Prézeau, L.; Trinquet, E.; Pin, J.-P.

And when you chain your highest-paid scientists to repetitive admin work, you’re not solving problems That’s a chaos tax — and you’re paying it in cash, time, and morale.

Currently, attention was mainly paid to biased signaling modulators targeting G protein-coupled receptors

We aimed to exploit other mamba venoms to enlarge the V2R-Kunitz peptide family and gain insight into

Listeners will gain perspective on: Assay choice as strategy , not convenience.

In This Session, You’ll Gain: ✅ Modeling tools to understand how restricted diffusion  in tissues like

and Gαi1, respectively (Figure 2B), as well as different coupling preferences between specific Gβγ pairs delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

Pay attention to that. What began as a quiet obsession soon demanded a bigger stage. control localised signaling, how disease hijacks these systems, and how to target them for therapeutic gain But so did choice.

In This Session, You’ll Gain: ✅ A clear explanation of why allosteric modulators don’t displace ligands—they

Introduction Cannabinoid receptors are GPCRs, and two main types exist, CB1R and CB2R.

In this session, you’ll gain: ✅ A clear breakdown of how intracellular vs. extracellular receptor access

Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form

In this session, you’ll gain: Clarity on high-impact early safety assays and their compelling rationale Understanding of toxicological mechanisms shaping go/no-go choices Strategic insights into early identification

While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point

Many early-stage biotechs show the same pattern: strong scientific progress paired with an operating discipline, the organization typically shifts from “busy but slightly lost” to “focused, aligned, and gaining But what kills momentum is timing inconsistency . 👉 Without a defined decision cadence: Choices get

What You’ll Gain Spot false confidence early  → Sensitivity differences can turn full agonists into partials

the interactions of SMO with cholesterol and other lipid molecules in the ciliary membrane, and to gain

Monash team built rotational PhD cohorts  — students cycled through multiple groups in their first year, gaining

Biologist Senior Scientist/Staff Scientist, Computational Chemistry GPCR Activation and Signaling A gain

Gain career inspiration from Ajay’s bold questions and pivots.

receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main

Her choice to stay in academia isn’t about rejecting industry—it’s about embracing the freedom to chase Like many young scientists, she explored different paths and gained industry experience before realizing whether to stay in academia or move into industry, Catherine speaks with unusual clarity about her choice

What you gain: Detect scaffold liabilities early—hERG inhibition, mutagenicity, and mechanistic red flags

In This Session, You’ll Gain Clarity on how ADME governs translational success A deeper understanding in vitro permeation assays  that enable early iteration Absorption failures are rarely about route choice

Deep mutational scanning, for instance, is gaining popularity as a strategy due to its ability to comprehensively