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also known to be capable of self-activation via an autoproteolysis process that removes the inhibitory GAIN

The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system

perception, and thought, and have the activation of serotonin (5-HT) 2A receptors (5-HT2A Rs) as a main

If you're navigating a stuck GPCR program, planning your next crucial milestone, or struggling to gain

The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system

First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain A.; Bazin, H.; Tinel, N.; Durroux, T.; Prézeau, L.; Trinquet, E.; Pin, J.-P.

Currently, attention was mainly paid to biased signaling modulators targeting G protein-coupled receptors

And when you chain your highest-paid scientists to repetitive admin work, you’re not solving problems That’s a chaos tax — and you’re paying it in cash, time, and morale.

We aimed to exploit other mamba venoms to enlarge the V2R-Kunitz peptide family and gain insight into

and Gαi1, respectively (Figure 2B), as well as different coupling preferences between specific Gβγ pairs delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

In This Session, You’ll Gain: ✅ Modeling tools to understand how restricted diffusion  in tissues like

Pay attention to that. What began as a quiet obsession soon demanded a bigger stage. control localised signaling, how disease hijacks these systems, and how to target them for therapeutic gain But so did choice.

Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form

In This Session, You’ll Gain: ✅ A clear explanation of why allosteric modulators don’t displace ligands—they

Introduction Cannabinoid receptors are GPCRs, and two main types exist, CB1R and CB2R.

While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point

In this session, you’ll gain: ✅ A clear breakdown of how intracellular vs. extracellular receptor access

Cy3B label of CELT-419, which fits well for FA and live-cell microscopy measurements, is not the best choice An Order of Magnitude Faster DNA-PAINT Imaging by Optimized Sequence Design and Buffer Conditions.

the interactions of SMO with cholesterol and other lipid molecules in the ciliary membrane, and to gain

Monash team built rotational PhD cohorts  — students cycled through multiple groups in their first year, gaining

receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main

Biologist Senior Scientist/Staff Scientist, Computational Chemistry GPCR Activation and Signaling A gain

Gain career inspiration from Ajay’s bold questions and pivots.

Her choice to stay in academia isn’t about rejecting industry—it’s about embracing the freedom to chase Like many young scientists, she explored different paths and gained industry experience before realizing whether to stay in academia or move into industry, Catherine speaks with unusual clarity about her choice

Deep mutational scanning, for instance, is gaining popularity as a strategy due to its ability to comprehensively

In This Session, You’ll Gain: ✅ The ability to calculate how many replicates you really  need for 95% By comparing two means (paired or unpaired) you’ll learn whether the divergence is genuine or whether

GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug At Alkermes, Sokhom Pin built an in vitro pharmacology group from scratch—not just a lab, but a culture

Gain invaluable skills in data analysis under Dr. Hoare's expert guidance.

In this session, you’ll gain: A clear conceptual map of Schild analysis and its origins.

Mandibulofacial dysostosis with alopecia results from gain-of-ETAR function via allosteric effects on