Search Results

Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

Hannes Schihada Following studies in Pharmacy in Regensburg, Germany, I joined the receptor pharmacology I spent 2 1/2 years in his lab and developed novel conformational sensors for these intriguing receptors

episode Fiona Marshall got fascinated with GPCRs after attending a lecture on how the beta-adrenergic receptor biology, Fiona published the first description of the cloning and structural requirements of the GABAB receptor

focuses on the mechanisms underlying biased signaling at GPCRs, specifically, the role of differential receptor He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed from other receptors this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor

obtained his Ph.D. from the University of Manitoba – Canada, where he was introduced to G protein-coupled receptors His doctoral research focused on the structural and functional characterization of bitter taste receptors

Aurelien Rizk shared that he had always focused on GPCRs but had also worked on other types of receptors Yamina Berchiche had a detailed conversation about the intricacies of cell signaling and chemokine receptors They validated their technology and made collaborations for expertise on chemokine receptors. Therapeutic Effect and Receptor Interactions Aurelien Rizk and Yamina had a detailed discussion about They emphasized the need to quantify the dynamics of the pathways and the residence time of the receptor

approaches to quantify ligand bias and the identification of ACKR3 as an endogenously beta-arrestin-biased receptor His group and others have shown that many of these ligands act as biased agonists for the same receptor

G protein-coupled receptors (GPCRs) mediate a vast variety of critical biological processes and provide for quantitative, and multi‐scale integration of these amounts of data to gain novel insights into receptor

also went on to discover a “counterion switch” in visual pigments and to develop strategies to assay receptor-G-protein from this work, such as the concept of “functional micro-domains” and the “helix movement model of receptor , the parallel development of bioorthogonal labeling strategies to couple fluorophores to expressed receptors

and received my Ph.D. in Molecular Medicine in 2010 after studying the orphan atypical cannabinoid receptor I studied the function of RGS5, calcium-sensing receptor, and an orphan adhesion GPCR, GPR64/ADGRG2 in

Since 2013, he has been elected Chair of the subcommittee for the Dopamine receptors of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification

within the research group and used this platform to develop nanobodies targeting viral G protein-coupled receptors with a special focus on the human cytomegalovirus-encoded chemokine receptor US28.

With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular

With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular

/ 2:10 PM About Karim Ibrahim "A postdoctoral researcher, interested in studying G-protein coupled receptors

tells a story November 11, 2025 Dr.GPCR Podcast Read full article Every receptor tells a story — but Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. Why receptor location matters as much as receptor type. October 27, 2025 Terry's Corner Read full article Receptor pharmacology has evolved. Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over

thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over

The result: a framework for designing ligands with altered receptor preferences. ♦️ Defines “public”

cryo-EM structures of Gq-bound PTH1R—highlighting how N-linked glycans and ICL2 interactions stabilize receptor

discover and develop highly effective cancer therapeutics by targeting heteromers of G protein-coupled receptors At Medarex, she initiated and identified the lead mAb for the type I interferon-alpha receptor project

Craig Malbon at SUNY Stony Brook studying the role of G-protein coupled receptors (GPCRs) and their regulators discussed his research on cell polarity and its role in cancer progression, his work on G-protein coupled receptors they face in studying GPCRs due to their low expression levels and the difficulty of localizing these receptors He also discussed his work on G-protein coupled receptors (GPCRs) in breast cancer, identifying GPR161 they face in studying GPCRs due to their low expression levels and the difficulty of localizing these receptors

➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/germline-mutations-in-a-g-protein-identify-signaling-cross-talk-in-t-cells

years of experience in GPCR, primarily focused on drug discovery and developing new tools to study this receptor

Brain Angiogenesis Inhibitor (BAI) proteins are members of group VII of the adhesion G protein-coupled receptor Kordon Abstract "Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved Ligand binding and mechanical force applied on the ECR regulate receptor function. alterations during neurodevelopment Mariam Melkumyan Abstract "GPR110, an adhesion G protein coupled receptor will give insight on the mechanism underlying the behavioral consequences associated with the GPR110 receptor

Current areas of interest include Protease Activated Receptor signaling in the cardiovascular system and regulation of vesicular exocytosis mediated by Gi/o-coupled receptors by G subunit binding to SNAREs

are pleased to welcome you at Le Château Montebello , the 22nd Annual Great Lakes G Protein-Coupled Receptor University of North Carolina at Chapel Hill, unquestionably one of the pioneers involved in deciphering how receptor