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out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors methods-and-updates-in-gpcr-research/development-of-a-nanobret-assay-platform-to-detect-intracellular-ligands-for-the-chemokine-receptors-ccr6

Home → Flash News → Forget one receptor at a time. GPCR Podcast Forget one receptor at a time. Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14 , the most promiscuous bitter taste receptor more about this exciting breakthrough in bitter taste signaling. ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling

Brian Shoichet BSc in Chemistry from MIT, Ph.D. with Tack Kuntz at UCSF; Postdoc with Brian Matthews in protein

the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered for Gq-coupled receptors.

shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor

Celtarys’ innovative chemical biology tools, making it easier than ever for scientists to study ligand-receptor Celtarys’ innovative chemical biology tools , making it easier than ever for scientists to study ligand-receptor Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug 🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13 ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13

Gunnar Schulte Gunnar Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. University, Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Most importantly my research team tries to understand underlying mechanisms of WNT-receptor interaction , the relevance of receptor dynamics, and receptor complex composition for signal initiation and specification

allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2 ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2

regulation of axonal transport by tricyclic antidepressants (M.Sc.) and molecular pharmacology of opioid receptors Marc Caron, where I cloned the dopamine D5 receptor gene and investigated the regulation of dopaminergic and adrenergic receptors. pursues the study of the molecular, structural, pharmacological and signaling features of dopamine (DA) receptors druggability potential of new signaling partners we identified that drive the formation of different DA receptor

the Dr.GPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor the Dr.GPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor

Why receptor location matters as much as receptor type. work bridges elegant mechanistic biology with translational impact — giving us new ways to think about receptor Premium → https://www.ecosystem.drgpcr.com/gpcr-university #GPCR #DrGPCR #pharmacology #drugdiscovery #receptors

Paul Clarck , where she studied opioid receptors. AstraZeneca as a postdoctoral trainee, where she studied animal models of pain and sensory neuron sensitive-receptor Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is Andrew Charles that who specialized in animal models of migraine and delta-opioid receptors as a therapeutic

Trained as a biochemist, he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter

build Virtual Reality solutions for Scientists and Engineers working at the nanoscale, specifically protein

can overcome these obstacles by producing high-quality antibodies that more accurately mimic natural protein

graduate school at the University of California at Irvine, studying the regulation of ionotropic glutamate receptors , Oregon, to do a post-doctoral fellowship in the laboratory of Thomas Soderling studying glutamate receptor continued his post-doctoral training at Duke University, where he studied the regulation of adrenergic receptors contributions to understanding the signaling, regulation and in vivo actions of the neuroprotective receptors Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb receptor

Uppsala University is redefining GPCR drug discovery with predictive molecular modeling that forecasts receptor Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

in his independent laboratory is focused on developing new pharmacological tools via chemistry and protein

Fung has spent significant time in the industry studying membrane proteins, antibodies, and HTS methods

pharmacologist and biophysicist, systems and synthetic biologist, technologist, heavy CRISPR user, protein

AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions behind founding Blue Therapeutics and targeting supraspinal pain pathway What it means to “teach AI protein

doctoral dissertation was the first large-scale study of structure-activity relationships for adenosine receptors postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor He then joined WL/PD, where his lab demonstrated the existence of two subtypes of the adenosine A2 receptor In 1988, he joined Lilly as a receptor biologist in charge of a high-throughput screening lab.

structural-and-molecular-insights-into-gpcr-function/structure-and-function-of-a-near-fully-activated-intermediate-gpcr-g% structural-and-molecular-insights-into-gpcr-function/structure-and-function-of-a-near-fully-activated-intermediate-gpcr-g%

Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core.

But during a summer internship in protein purification, he faced a harsh reality: lab work wasn’t his

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor