Search Results

September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization We investigated the influence of specific inhibitors of G protein-coupled receptors (GPCR), endocytosis The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA Overall, phagocytosis, CME, GPCR, ERK signaling, and S2R/TMEM97 are involved in the internalization of Read more at the source #DrGPCR #GPCR #IndustryNews

This makes it an ideal candidate for GPCR research, where accuracy in detecting subtle signaling changes Enhancing HTRF Assay Performance in GPCR Research Using Fluorescent Ligands GPCRs are involved in numerous GPCRs are not always the most numerous in cells. FRET-based technologies by providing high-performance fluorescent ligands designed specifically for pharmacological ligands offer both high affinity and exceptional selectivity across a wide range of GPCR targets.

Jianming Han, Tao Che for their analysis of GPCR-G protein selectivity revealed by structural pharmacology , and more International Union of Basic and Clinical Pharmacology. Cryo-EM advances in GPCR structure determination GPCR-G protein selectivity revealed by structural pharmacology and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology NEW Senior Director GPCR Drug Discovery Biologist Post-Doctoral Scientist- Molecular Pharmacology (FDE) Research

We have gathered 24 new research papers on GPCRs and updates on industry news related to GPCRs. and Clinical Pharmacology 2026 GPCR Jobs NEW Scientist; Biochemistry, Cellular and Mechanistic Pharmacology Director GPCR Drug Discovery Biologist HIGHLIGHT Principal Scientist, In vitro pharmacology Post-Doctoral Scientist- Molecular Pharmacology (FDE) Research Assistant Senior Scientist - Receptor Pharmacology GPCR Ecosystem

showed that the receptor is a member of the Octβ3 protein family, and an analysis using quantitative PCR This study demonstrated the pharmacological properties and functions of PxOctβ3 in P. xylostella, thus Read more at the source #DrGPCR #GPCR #IndustryNews

Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. , multiplexed platform to investigate GPCR-RAMP biology  like never before. that these small, single-transmembrane proteins weren’t just chaperones; they actively shaped receptor pharmacology interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr. GPCR ecosystem

World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology NEW Post-Doctoral Scientist- Molecular Pharmacology (FDE) NEW Research Assistant Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Senior Research Associate/Associate Scientist , Protein Science Post-Doctoral Fellow—Pharmacology/Cell Biology/Biochemistry Join Dr. GPCR Ecosystem

GPCR Consortium: The 11th Adhesion GPCR Workshop. World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Senior Research Associate /Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell Biology/Biochemistry Post GPCR Ecosystem

resurgence in recent times for exploratory analyses to identify previously unknown regions critical to GPCR In summary, mutagenesis can be a critical tool in drug discovery, particularly for studying GPCRs. The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and Molecular determinants of ligand efficacy and potency in GPCR signaling. Molecular Pharmacology ,  90 (6), 703-714.

🚨 Hurry to reserve your spot for the Principles of Pharmacology I & II BUNDLE before the Early ) Topics: Pharmacologic activity measurement, mechanisms of action, and GPCR discovery strategies. Registration deadline: September 27, 2024 Principles of Pharmacology II Dates: October 31, November Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology

GPCR Podcast, we have Dr. Pina Cardarelli, CSO of GPCR Therapeutics. ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr#drgpcr #podcast

October 2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one endogenous ligands (orthosteric site), allosteric modulators offer new avenues for the regulation of GPCR Recent advances in the structure determination of GPCRs bound to different types of allosteric modulators In this review, we provide a systematic analysis of the currently available GPCR structures in complex Read more at the source #DrGPCR #GPCR #IndustryNews

Watch Episode 167 Today’s GPCR scientists don’t want to study one interaction, they want to model the protein interactions  (e.g., 14-3-3) Heterodimerization Endogenous vs. overexpressed systems Orphan GPCR scientists are already expanding this work, bringing in computational layers  like AlphaFold to model GPCR-RAMP Listen to the complete episode to learn more. _________________ Keyword Cloud : GPCR scientist network , GPCR online course , GPCR data platform , multiplex assays , GPCR drug discovery

Molecular innovation This Week’s GPCR Intelligence: The next edge in discovery isn’t louder exposure—it Breakthroughs this week:  nanomedicines targeting PAR2 for sustained analgesia; Emerging Voices in GPCR GPCR Premium: Sneak Peek Industry insights:  Confo VLAIO grant; Skye CB1 Ph2 miss; Chugai CT-388 in-license Upcoming events:  Membrane-mimetic screening; GPCR Forum 2025; GPCR-TDD Summit Europe. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

They have also been used as biosensors to monitor conformational changes of GPCRs in living cells. Some Nbs that have been use for GPCR research are: Nb80: This nanobody stabilized an active-state conformation Nb7: This nanobody improves the diffraction quality of the constitutively active GPCR US28·CX3CL1 complex5 Annual review of pharmacology and toxicology, 57, 19–37. https://doi.org/10.1146/annurev-pharmtox-010716

September 2022 "Background and purpose: The interaction of arrestins with G-protein coupled receptors (GPCRs GPCRs that internalize without arrestin have been classified as "class A" GPCRs whereas "class B" GPCRs The interaction of arrestins with GPCRs requires both agonist activation and receptor phosphorylation Read more at the source #DrGPCR #GPCR #IndustryNews

Among the different families of G-protein-coupled receptors (GPCRs), adhesion GPCRs (aGPCRs) represent As occurs with other GPCRs in an active state, in aGPCRs the rearrangements induced by the interaction formulate strategies to help modulate the activation and signaling of these receptors, particularly with a pharmacological Barros-Álvarez, X., et al., The tethered peptide activation mechanism of adhesion GPCRs. -Q., et al., Structural basis for the tethered peptide activation of adhesion GPCRs.

Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

GPCR Symposium on GPCR activation and signaling sessions. in Oncology and Immunology Polarizing itch Biochemical pharmacology of adenylyl cyclases in cancer Methods World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Postdoctoral Associate Research Technologist Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory

Hello GPCR Innovators ,   We’re preparing to launch Terry’s Corner, a new knowledge hub shaped by Dr. Terry Kenakin’s decades of GPCR insight. It will bridge foundational receptor theory with today’s most pressing pharmacological questions, from pharmacology screens, anchored in real-world lessons and cutting-edge science.   GPCR Team

The study focused on two critical pharmacological properties: efficacy and potency. distinction is essential for designing drugs that selectively target these residues to achieve desired pharmacological The identification of pharmacologically significant residues enables more accurate predictions of how Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery. Dr. GPCR Ecosystem; Dr. GPCR Ecosystem. https://www.ecosystem.drgpcr.com/post/decoding-gpcr-function-the-role-of-mutagenesis-in-rational-drug-discovery

Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Associate Research Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory

regulating the dynamics of the serotonin1A receptor, a crucial neurotransmitter G protein-coupled receptor (GPCR in understanding the modulatory role of the membrane environment on the organization and dynamics of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

Riding the GPCR Rollercoaster Early in his career at DuPont and BMS, GPCRs were red hot. “Companies started shutting down neuroscience and GPCR programs. But I stayed,” Sokhom said. refining assays, exploring signaling bias, and building a robust knowledge base in one of the most pharmacologically The Payoff of Staying Focused Today, GPCRs are making a comeback in popularity. drug discovery , G protein-coupled receptors , GPCR webinar series , GPCR scientist network , GPCR research

Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91 Specific pharmacological World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Research Technologist I Senior Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory

GPCR University Today marks the conclusion of the Dr.GPCR University course, ‘Applying Pharmacology to β2 Adrenergic Receptor at the Single-Molecule Level Pharmacological characterization of seven human Events, Meetings, and Webinars February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Senior Scientist- Internal Medicine Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory

GPCR Symposia Our upcoming symposium on March 15th is about GPCR activation and signaling. GPCR University Last week marked the beginning of our first Dr.GPCR University course, 'Applying Pharmacology Events, Meetings, and Webinars February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Director of Laboratory Operations GPCR Ecosystem

and 2 GPCR events! GPCR University We're thrilled to share that all spots for the Applying Pharmacology to Drug Discovery GPCR Partnered Events 3rd GPCRs - Targeted Drug Discovery Summit  Join us at the 3rd GPCRs Targeted Drug 11 - 14, 2024 | 2024 BPS Annual Meeting NEW February 20, 2024 | Career Opportunities in Pharmacology World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Post-Doc position Lead Researcher Senior

one GPCR Event, and two GPCR job ads! GPCR University course, Applying Pharmacology to Drug Discovery, led by Dr. The course covers basic pharmacology in four weekly segments and is open to all with a free site membership World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Post-Doc position NEW Lead Researcher GPCR Ecosystem

We’ve curated 10 GPCR papers, seven industry news, and two GPCR job ads! This week's highlight: Dr. GPCR University February 8 - 29: Join Dr. GPCR University's live course with Dr. Terry Kenakin. The course covers basic pharmacology in four weekly segments. World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Senior Researcher in Structural GPCR Ecosystem