Search Results

After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case This case study underscores the critical importance of mutagenesis in GPCR research. Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery. Dr. GPCR Ecosystem; Dr. GPCR Ecosystem. https://www.ecosystem.drgpcr.com/post/decoding-gpcr-function-the-role-of-mutagenesis-in-rational-drug-discovery Molecular determinants of ligand efficacy and potency in GPCR signaling.

GPCR Podcast features a recap of the Endocrine Metabolic GPCRs 2024 with the organizers, Drs. Adhesion GPCR Consortium: The 11th Adhesion GPCR Workshop. Adrenal Hyperplasia (CAH) and ACTH-Dependent Cushing’s Syndrome (ADCS) Septerna Presents Preclinical Data at ENDO 2024 Highlighting Therapeutic Potential of its GPCR Drug Discovery Platform GPCRs and Emotional GPCR Ecosystem

Check out our GPCR coverage for this week. GPCR Symposia Mark your calendars! April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR Founder Dr. and SMALPs as a platform for investigating GPCRs Reviews, GPCRs, and more Fragment-Based Design, Synthesis GPCR Ecosystem

But Sokhom Pin stayed loyal to GPCRs , even when big pharma turned its gaze to other targets like kinases Riding the GPCR Rollercoaster Early in his career at DuPont and BMS, GPCRs were red hot. “Companies started shutting down neuroscience and GPCR programs. But I stayed,” Sokhom said. The Payoff of Staying Focused Today, GPCRs are making a comeback in popularity. drug discovery , G protein-coupled receptors , GPCR webinar series , GPCR scientist network , GPCR research

We are thrilled to present our comprehensive GPCR coverage for the week; we have 14 GPCR papers, six GPCR Symposia Our upcoming symposium on March 15th is about GPCR activation and signaling. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. promoting an alternative-like polarization during bacterial infection Industry News InterAx Biotech's AI platform GPCR Ecosystem

Check out our GPCR coverage for this week. GPCR Symposia Our upcoming symposium on March 15th is about GPCR activation and signaling. Let’s dive into the Classified GPCR News from February 5th to 11th, 2024 GPCR Activation and Signaling Industry News Exscientia Initiates Clinical Study to Further Evaluate Functional Precision Medicine Platform GPCR Ecosystem

GPCR Podcast Episode 154 of the Dr. GPCR Consortium: The 11th Adhesion GPCR Workshop will take place in vibrant Mexico City from October GPCR Activation and Signaling Highly biased agonism for GPCR ligands via nanobody tethering Mechanistic Industry News Structure Therapeutics Reports Positive Topline Data from its Phase 2a Obesity Study and GPCR Ecosystem

news, and 2 GPCR job offers! Save the date: February 8 - 29: Join Dr. GPCR University's live Zoom sessions hosted by Dr. GPCR Access to Dr. Therapeutics Provides Comprehensive GSBR-1290 Program Update Including Clinically Meaningful Proof-of-Concept Data GPCR Ecosystem

Look at our curated GPCR coverage for this week, which includes 10 GPCR papers, seven industry news, and 2 GPCR events! GPCR Symposia Our first upcoming symposium on March 15th this year is about GPCR activation and signaling GPCR Partnered Events 3rd GPCRs - Targeted Drug Discovery Summit  Join us at the 3rd GPCRs Targeted Drug GPCR Ecosystem

AlphaFold, homology modeling was the most common method for predicting G protein-coupled receptor (GPCR ) structures, especially when experimental data were limited. GPCRs are dynamic, switching between multiple conformations, and many have only distant homologs with The introduction of AlphaFold2 marked a major advancement in the field of GPCR structure prediction. leading to more comprehensive models that bridge the gap between computational predictions and real-world data

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between GPCR Symposium on GPCR activation and signaling sessions. presentation to our community, take advantage of networking opportunities, and raise your profile on our platform GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs pharmaceutical scientists honoured in NHMRC Research Excellence Awards Domain Therapeutics to Present Latest Data

Check out our curated GPCR coverage for this week, which includes 14 GPCR papers, four industry news, one GPCR Event, and two GPCR job ads! GPCR University Our first Dr. GPCR at the Endocrine Metabolic GPCRs Summit on April 22-23, 2024, in Birmingham, UK. Dr. GPCR Ecosystem

Developing Small Protein Therapeutics with a Novel Discovery Platform One way to overcome the challenges The PROcisionXᵀᴹ platform (summarized in Figure 2) can be used to complete a discovery campaign within Figure 2: Workflow in Orion’s PROcisionXᵀᴹ platform. Figure 3: In a single discovery campaign (CCR5 is shown as an example), Orion’s PROcisionXᵀᴹ platform Available structural data across the GPCR superfamily is increasing at an exponential rate, alongside

Dive into our GPCR coverage for this week! We’ve curated 10 GPCR papers, seven industry news, and two GPCR job ads! This week's highlight: Dr. GPCR University February 8 - 29: Join Dr. GPCR University's live course with Dr. Terry Kenakin. GPCR Complimentary one-year Dr. GPCR Ecosystem Premium memberships,  a $250 saving Access to Dr. GPCR Ecosystem

The newest GPCR research is hot off the press! We’ve curated 18 GPCR papers, 8 industry news, and 2 GPCR job offers! Save the dates: February 8 - 29: Join Dr. GPCR University's live Zoom sessions hosted by Dr. GPCR Complimentary one-year Dr. GPCR Ecosystem Premium memberships, a $250 saving Access to Dr. GPCR Ecosystem

Hello GPCR people! We have great news! Take a few minutes, and dive into our GPCR coverage! We welcome GPCR paper suggestions! Adhesion GPCRs The Posttraumatic Increase in the Adhesion of GPCR EMR2/ ADGRE2 to Circulating Neutrophils GSK Novartis drops subpoena request in trade-secret spat with Takeda Novartis showcases significant data GPCR Ecosystem

We’ve curated 23 GPCR papers, four industry news, and 3 GPCR job posts! This week's highlight: Drs. signaling Save the date: February 8 - 29: Join Dr. GPCR Ecosystem Members! GPCR Access to Dr. GPCR Ecosystem

Save the dates: November 2 - 4: We're sponsoring the GPCR Retreat and would love to meet you there! GPCR Symposium of the year on GPCRs in Immunology and Oncology! Novo Nordisk to Buy Hypertension Treatment from KBP Biosciences Exscientia to Present New Preclinical Data cell surface protein in yeast cells Trevena Reports Favorable TRV045 Topline Safety and Tolerability Data GPCR Ecosystem

GPCR Event Highlight Join us in vibrant Mexico City from October 23-25, 2024, for the 11th Adhesion GPCR Let’s dive into the Classified GPCR News from July 22 to 28, 2024 GPCR Activation and Signaling Activating targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation Signaling Bio-Rad Adds Rapid Bispecific Antibody Prototyping and Screening Services to Pioneer Antibody Discovery Platform GPCR Ecosystem

Hi GPCR lovers! Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr. GPCR University live Zoom sessions hosted by Dr. Terry Kenakin. , and more Structure, function and drug discovery of GPCR signaling Illuminating the understudied GPCR-ome GPCR Ecosystem

GPCR Symposium for the year, focusing on GPCRs in Immunology and Oncology, concluding the Dr. GPCR Symposia 2023. Adhesion GPCRs CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps GPCR Activation Research Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically GPCR Ecosystem

November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved The structures also reveal the uncharted structural information of GPCR/G12 coupling. Taken together, our study lays the groundwork for understanding aGPCR activation and G-protein-coupling Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE

G protein-coupled receptors (GPCRs) are membrane-bound proteins that sense external stimuli and relay While GPCRs can exist as monomers, some types, like class C GPCRs, are obligate dimers, either as homodimers Class B1 GPCRs are an important subclass of GPCRs that include 15 receptors involved in regulating body for our understanding of GPCR function and signal transduction. Tate, New insights into GPCR coupling and dimerisation from cryo-EM structures.  

GPCR Symposia Mark your calendars! GPCR University Great News! The Dr. Hoare, you’ll learn how to analyze your data like a pro. Stay tuned for more information. Dr. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs GPCR Ecosystem

These data lead us to a model where Kel1 promotes completion of cytokinesis before pheromone-induced Read more at the source #DrGPCR #GPCR #IndustryNews

Our final opsin phylogeny is the largest to date with 4956 opsins. Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE

We will be back next week with our regular weekly GPCR news digest. In the meantime, you can always check the  Classified GPCR News from the last weeks. GPCR Podcast. GPCR. Today is also the first session of our hands-on workshop with Dr. Sam Hoare. GPCR University content coming soon.

GPCR Symposium on 'GPCRs as Therapeutic Modalities'. GPCR Newsletter! Second Quarter 2023 Results and Provides Business Update Crinetics Pharmaceuticals: Paltusotine Phase 3 Data Regulatory Affairs Research Scientist/Senior Scientist I - Molecular Pharmacology Director, Clinical Data GPCR Ecosystem

GPCR Symposium about 'GPCRs as Therapeutic Modalities' rocked it! Save the dates: November 2 - 4: We're proud sponsors of the GPCR Retreat and can't wait to meet you there GPCR Newsletter! Dive into the Classified GPCR News from September 18th to 24th, 2023. Announces Site Relocation AI can help to speed up drug discovery — but only if we give it the right data GPCR Ecosystem

GPCR podcast with Dr. Nicole (Nicki) Perry-Hauser is now available What a fun chat! GPCR Ecosystem paid membership to enjoy everything Dr. GPCR has! ➡️https://bit.ly/3TCJVQQ #gpcr #drgpcr