Search Results
Results found for "Howard Hughes"
- 📰 GPCR Weekly News, May 8 to 14, 2023
Drugs, and more In-depth molecular profiling of an intronic GNAO1 mutant as the basis for personalized high-throughput
- From Snapshots to Predictions: Why Mechanism of Action Matters
A model answered: yes—provided CD4 concentrations stayed low and gp120 concentrations high.
- How Understanding Intracellular Drug Access Can Transform Your GPCR Drug Discovery Program
Amplify your research: Contribute to a high-impact collection of work that will shape the future of
- 📰 GPCR Weekly News, June 26 to July 2, 2023
High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Introduction Life scientists dedicate enormous resources towards meticulously understanding and implementing prime targets, it is our duty to routinely clean our lens of misleading artefacts and focus our efforts towards
- 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)
receptor 4 (PAR4) in mouse models of acute and chronic kidney injury GPCR Binders, Drugs, and more High-throughput
- 📰 GPCR Weekly News, November 20 to 26, 2023
Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment High
- 📰 GPCR Weekly News, April 24 to 30, 2023
Adhesion GPCRs Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed-atomic
- 📢 Early Bird Registration Ends Tomorrow! | Sep 16 - 22, 2024
Should Enroll Now: Budget-Friendly & Distinctive Educational Experience Affordable courses that maintain high-quality
- 📰 GPCR Weekly News, February 12 to 18, 2024
Broadens Biased Ligand Pharmacology Pharmacological characterization and radiolabeling of VUF15485, a high-affinity
- 📰 GPCR Weekly News, December 11 to 17, 2023
a new biotech with $52M from VC fund ATP Structure Therapeutics - Providing the next generation of high-impact
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
Goyet, E., et al., Fast and high resolution single-cell BRET imaging.
- Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery
Why it matters: Allosteric inhibitors often retain potency under high substrate conditions, such as ATP-rich
- 📰 GPCR Weekly News, April 8 to 14, 2024
Let’s dive into the Classified GPCR News from April 8th to 14th, 2024 Adhesion GPCRs High incidence of
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
GPCRs have been identified to exist in at least two distinct states: an active state characterized by high
- New role of β-arrestins in MOR signaling
(MOPR) and one of the objectives in the development of new opioids is to synthesize compounds with high
- Hop in the Time Machine with GPCR: Unraveling the Future of Research! ⦿ Nov 24 - Dec 1, 2024
the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies High-affinity
- Orthosteric vs Allosteric Interactions— and the pHSense Shift in Internalization
Why It Matters Instead of imaging-heavy workflows, pHSense offers a no-wash, plate-reader–ready, high-throughput
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
gpcr-binders-drugs-and-more/in-depth-molecular-profiling-of-an-intronic-gnao1-mutant-as-the-basis-for-personalized-high-throughput-drug-screening
- Targeting Intracellular Allosteric Sites in GPCRs
Structural studies at high resolution have illuminated the intricate interactions between NTSR1 and GRK2
- Glyco-sulfo hotspots in the chemokine receptor system
of the negatively charged aminoacids and post-translational modifications (PTMs), contribute to the high
- Ode to GPCRs
Therefore, we envision that this field will continue to produce high-impact research work that will garner








