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Dylan Scott Eiger, Chloe Hicks,  Dr.

January 2022 "Voltaire argued, “Perfection is attained by slow degrees; it requires the hand of time.” However, in drug discovery projects, perfection can’t be attained soon enough. A project to develop a perfect drug, or a drug that is as safe and effective as possible, may never begin if it can’t be completed quickly. Such predicaments must have been familiar to the philosopher. After all, he also complained that the perfect is the enemy of the good. If only Voltaire were here today to see how drug discovery is being accelerated by new technologies. He might reverse himself and declare that the perfect can in fact be the friend of the good. Several new technologies that are being used to accelerate drug discovery are highlighted in this article. They include small molecules that conditionally modulate proteins in their functional state; three-dimensional (3D) cell models, or organoid models, that assist with target identification, high-throughput drug screening, drug efficacy analyses, and toxicity studies; technologies that stabilize G protein–coupled receptors (GPCRs) to enable the discovery of agonistic biologics; and automated instrumentation that enables the overnight synthesis of mRNA." Read more at the source #DrGPCR #GPCR #IndustryNews

part as adjuvant therapy at single administration or in combinatorial human trials, arising as a good pick

We kick off with a question that cuts deep: What if your models could actually predict the future? It’s built to compress your time to clarity—so you can pick better targets, stress-test hypotheses earlier

You’ll explore: What makes a “discovery team” tick (and why teamwork is non-negotiable) The difference

Structural and Molecular Insights into GPCR Function Physiological changes in bilayer thickness induced The delisting dilemma: Why do so many biotechs face being kicked off the Nasdaq?.

Access the Course Hacking GPCRs: A Toolkit for Systems Biology – New Podcast Episode In Episode 167,

Jonah Comstock delves into what makes this team-up tick.

and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signal pathway A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles The far extracellular CUB domain

Why Faster, Smarter Decisions Require More Than Kd In drug discovery today, the clock is always ticking

Financing Deal of the Year at the Citeline Japan Awards 2024 GPCR therapies: Eight promising biotechs hacking

Aaron McGrath from Takeda   🎥 Interview with Kris Borzilleri & Alison Heick Varghese from Pfizer 🎥

A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants,

Courses Highlights The clock is ticking!  

Before the new semester kicks off, dive into our premium on-demand courses!

Ligands come and go, feedback loops kick in, and what you see in vitro rarely tells the whole story.

Target 2025 Speaker Spotlight: Solubilization, Orphans & Lipid Systems In a conversation with Alison Heick

neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake The tick

neuropeptide receptor conservation across phylum Nematoda Target-based discovery of antagonists of the tick

GPCR Kicked Off as a Podcast...

Mechanism of the GPR183 Receptor GPCR Binders, Drugs, and more Target-based discovery of antagonists of the tick

deorphanization of three inotocin (insect oxytocin/vasopressin-like) receptors and their ligand from the tick

Mark your calendar for October 23 - 25, 2024, as we kick off the 11th Adhesion GPCR Workshop in Mexico

.; Pick, H.; Vogel, H.; Johnsson, K.