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year, Novo Nordisk is strengthening its position in the obesity space through a collaboration with EraCal Under the joint research plan, the Danish giant will work with EraCal to identify novel drug targets Although specific details of the collaboration are yet to be released, EraCal has confirmed that the

Eric Trinquet, a veteran innovator behind functional GPCR assays like HTRF and IP-One, believes rigid “You can try, try, try—and fail, fail, fail,” Eric says. Instead of chasing linear progress, Eric encourages young scientists to stay playful longer—embracing Eric and his team rejected the calcium route entirely. Eric is clear: real innovation requires real partnerships.

Watch Episode 167 Today’s GPCR scientists don’t want to study one interaction, they want to model the network. In Episode 167, Dr. Sakmar reflects on a generational shift in training. The newest scientists want scalable, automated systems and the tools to move from data collection to insight . Building for the Future The Sakmar lab built a system to meet that need: Dual-epitope tagged constructs (N-term FLAG, C-term 1D4) Compatible with multiple readouts: proximity, immuno assays, pulldowns Validated antibodies + digital search platform Entire library hosted on Addgene This wasn’t a flash-in-the-pan project. It was structured, collaborative infrastructure . “The students of today want biosensors, miniaturization, and multiplexing. This delivers all three.” — Tom Sakmar A Use Case for Every Angle Beyond RAMPs, this platform can study: Scaffold protein interactions  (e.g., 14-3-3) Heterodimerization Endogenous vs. overexpressed systems Orphan GPCR deorphanization Ligand screening and functional validation Training the Next Wave Graduate students and visiting scientists are already expanding this work, bringing in computational layers  like AlphaFold to model GPCR-RAMP complexes in silico. Kotliar sums it up best: “We went from one receptor to many… and now, from many, we can go back to one, with purpose.” Listen to the complete episode to learn more. _________________ Keyword Cloud : GPCR scientist network , GPCR online course , GPCR data platform , multiplex assays , GPCR drug discovery

September 2022 Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal the possible role of the K101 residue in a cholesterol recognition/interaction amino acid consensus (CRAC

Eric Trinquet, Director of Research and Development at Revvity.   Eric Trinquet  to the Dr. precision reagents and validated assay platforms. 🔍 Learn More → Listen to the Podcast with Revvity’s Eric

Exploring the foundational stages of scientific breakthroughs with Eric Trinquet, highlighting that true Eric Trinquet shares what it really takes to bring a product to life—from sketch to shelf. Eric Trinquet joined Cisbio in the early 2000s, working on what would become HTRF—Homogeneous Time-Resolved Eric Trinquet The Real Work Starts Before the Lab What most scientists don’t see is how long a product

Eric Trinquet, that moment arrived when his team successfully tracked GPCR internalization in native That’s the promise of pHSense, a groundbreaking reagent developed by Eric Trinquet and his team at Revvity Eric Trinquet.

Eric Trinquet, the scientist behind IP-One, Tag-lite, and now pHSense, challenges conventional scientific From failing fast to embracing serendipity, Eric shares the mindset (and messy origin stories) that shaped

adenosine monophosphate (cAMP), Ras homolog family member A (RhoA), exchange protein activated by cAMP (Epac

Eric Trinquet shares in a special Dr.

Eric Trinquet traces how a series of bold pivots—from Cisbio’s HTRF platform to IP-One and now pHSense—reshaped

Addex Provides Corporate Update And Financial Guidance Structure Therapeutics Appoints Industry Leaders Eric

Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to

Eric Trinquet and his team at Revvity, that moment came when they watched GPCRs internalize in native

employed in GPCRs mediated signal transduction.[47] The 2000 Nobel Prize in Physiology or Medicine went to Eric Eric R.