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recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion Lanier ,   Brian K Shoichet ,  Esther Martinborough ,  Jonathan F Fay ,  Can Cao ,   Bryan L Roth , et al.

Esther 2023). The 30s-loop of chemokines can bind either on top of the extracellular loop 2 (ECL2) or inside the major

byproduct obtained by the O-acylisourea rearranging intramolecularly into the N-acylurea.[ 2]     NHS ester NHS esters are not very stable even in aqueous environment but they only need a slightly basic medium

Activation of either D2 or GABAB receptors also acutely desensitized the GIRK channel current induced Results demonstrate that the activity of either G protein-coupled receptor system must be considered

and isolation of A2AAR and assembly of A2AAR in lipid nanodiscs and procedures for incorporation of either

and isolation of A2AAR and assembly of A2AAR in lipid nanodiscs and procedures for incorporation of either

While GPCRs can exist as monomers, some types, like class C GPCRs, are obligate dimers, either as homodimers These dimeric forms, which can either be transient or stable, are believed to influence the function

THP-1 cells were activated and differentiated into either M1 or M2 macrophages.

These can be used either as stand-alone therapeutics or to improve the safety profile of opioid drugs

This session unpacks how persistent binding can either accelerate your program—or quietly kill it. Why Tight Binding Isn’t Always Good News When a drug won’t let go, you can’t either.

from behavioral and physiological studies implying that bias toward or against D1-mediated β-arrestin either

substitution of one amino acid by another in a protein can have effects ranging from negligible to dramatic, either Through either random or targeted (site-directed) approaches, mutagenesis can provide a comprehensive

The temporal signals could implicate either GPCR/14-3-3 complex dissociation or the complex undergoing

evidence supporting the use of various drugs including orthosteric and allosteric ligands acting on either

(AHH) is a rare disease caused by calcium-sensing receptor (CaSR) autoantibodies, to date, showing either

Indeed, ACKRs behave as scavenging “decoys” in order to either limit chemokines spatial availability

The inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise

The Allosteric Shift: When Receptors Become Something New In orthosteric pharmacology, a ligand is either

Cells Are Highly Dynamic during Collagen-Induced Arthritis "The sympathetic nervous system (SNS) has either

Transfected HEK-293 cells were assessed for Ca2+o -stimulated Ca2+i mobilization using mutations in either

Activation of melatonin MT2 receptors with either pharmacological concentrations of melatonin (10-100

visualization and quantification of SST2/SST5 dimerization in rat GH3 as well as in human melanoma cells either

Small-interfering RNA (siRNA) technology was also used to knockdown either ROCK1 or ROCK2.

libraries typically leads to the isolation of several hundred candidate hits, enriched because they either the ensemble of candidate hits provides a rich resource of information to inform lead optimization, either agonists with different levels of signaling activity, biased agonists that preferentially activate either The cytotoxic drug Monomethyl auristatin E (MMAE) was used alone or conjugated to either the native CCL5

different fusion proteins and also this different molecular codes will be modulated by different opioids, either

Furthermore, understanding these resistance mechanisms enables the design of next-generation drugs that either

/inverse agonism, where the allosteric modulator can perturb receptor signaling in a manner that is either

The development of antibodies directed towards an OR could either drive receptor inactivation or activation

chemokine receptors (ACKRs) which do not couple to G proteins and behave as scavenging “decoys” in order to either

Chemokine receptors have either reported or predicted sites of N-acetyl galactosamine (GalNAc)-type O-glycosylation