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GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

But something shifted.

extended fluorescence duration, enable delayed emission readings, have narrow bands and high stokes shift

Systems for GPCR Drug Discovery The only way out for GPCR drug discovery programs isn’t more people or shinier

Kenakin’s latest lecture delivers a paradigm shift for pharmacologists working on drugs where in vitro

Why Misreading Antagonism Delays GPCR Drug Discovery If a dose-response curve shifts to the right, you DR curves shift to the right with no loss of maximal effect. One shifts neatly to the right without dropping the maximum.

—Alessandro Nicoli A New Era of GPCR Research AlphaFold didn’t just fill a gap—it shifted the focus of

Imagine you're navigating a vast terrain—not on foot, but through the shape-shifting world of GPCRs.

It’s about a dynamic dance of chemical forces, equilibrium shifts, and molecular decisions that determine

I know how to ask the right scientific questions—and when to shift from analysis to execution.

But then came the industry shift. “Companies started shutting down neuroscience and GPCR programs.

some agonists succeed in sensitive tissues but fail elsewhere—and how this knowledge can dramatically shift

GPCR-targeted drugs fail—not because of poor chemistry, but because we’ve misunderstood how these shape-shifting

been used to study GPCRs for decades, but with the advances in the fluorescence field, assays have shifted

“The first time I wore my lucky cactus shirt to a major meeting... and it led to a game-changing collaboration

Sakmar reflects on a generational shift in training.

For example, some assays benefit from using a more red-shifted fluorescent label or a combination of

Why It Matters This isn’t just a dataset, it’s a shift in how GPCR biology is approached : Study known

That’s not an incremental advance; that’s a potential paradigm shift.

The GPCR ship is setting sail on a grand voyage across the vast ocean of research.

Let's make your brand shine like never before! Events, Meetings, and Webinars October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

Events, Meetings, and Webinars October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

Logo Contest : Let your creativity shine! adrenergic receptors GPCRs in Neuroscience In-silico predicted mouse melanopsins with blue spectral shifts GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift

Logo Contest : Let your creativity shine by submitting your design for the Logo Contest before August in Medicinal Chemistry NEW October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift