Search Results

In GPCR drug discovery, a single mistaken assumption can derail an entire program. Terry Kenakin reframes one of pharmacology’s most foundational ideas: the difference between competitive Inside the Lesson: Antagonist Behavior by the Numbers Terry walks through both the pharmacologic and If you want to avoid costly misinterpretations and strengthen your pharmacology toolkit, Terry’s Corner Brief today  ➤   #GPCRantagonism #CompetitiveAntagonists #NonCompetitiveAntagonists #DoseResponseCurve #Pharmacology

Terry's Corner - New Course on Pharmacologic Models The latest Terry’s Corner unlocks clinical forecasting in the full newsletter   Secure Your Access Now ➤ 🗣️ “Thank you for bringing this (Principles of Pharmacology GPCR University Learner Dr. GPCR Podcast - Surviving Discovery’s Gauntlet Dr. Listen Now – Real Lessons from a GPCR Expert ➤ The future of GPCR isn’t waiting. GPCR Team Read Full Edition ➤

GPCR and Revvity. GPCR internalization isn’t just a trafficking readout—it’s pharmacology. pharmacology) was not transactional. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Each week we highlight the decisions that move GPCR projects forward—from pharmacology essentials to Years of chemistry, photophysics, and pharmacology condensed into one breakthrough: pHSense , a reagent They translated a fundamental principle of chemistry into a usable platform for pharmacology—showing GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need The pace of GPCR innovation is accelerating.

Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. Schild analysis turns receptor pharmacology into detective work, spotlighting mechanistic fingerprints Modern pharmacology has powerful modeling software, yet Schild analysis remains the litmus test for mechanism Watch the course trailer 👇 Why Terry’s Corner Weekly pharmacology lectures by Dr. GPCR innovation is accelerating—those who act now will define tomorrow’s breakthroughs.

Every R&D team is under the same pressure: deliver validated targets, clean pharmacology, and translatable Allosteric Interactions Still Matter Orthosteric and allosteric interactions have been in pharmacology learn why this distinction is not just theory, but a practical framework to design cleaner, smarter pharmacology Equip your team with this literacy now to design cleaner pharmacology and accelerate smarter, safer programs GPCR members save  50%+  (check your Weekly News code).

Hello GPCR Minds,   This week, you'll learn all about Terry’s Pharmacology Corner, your new learning space focused on GPCR pharmacology. GPCR Updates Learn Pharmacology That Drives Discovery  – From Dr. Terry Kenakin   Terry’s Corner is your space focused on GPCR pharmacology designed just for you.   GPCR Team

For over two decades, my work has centered on GPCR pharmacology . The GPCR Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes My Approach: Biology, Execution, Systems My consulting approach uniquely blends deep pharmacology expertise GPCR As the co-founder of Dr. GPCR, we've built a global hub connecting over 1,300 GPCR scientists dedicated to this field.

Recognizing, predicting, and leveraging these interactions is the essence of enzyme inhibition pharmacology This lesson reframes enzyme interaction not as background noise, but as a core pharmacological event. Clark , laid the foundation for today’s quantitative pharmacology. Enzyme Inhibition Pharmacology: Orthosteric vs. Pharmacology isn’t just about hitting the receptor—it’s about surviving the enzymes first.

Attrition rates in early pharmacology remain painfully high. The High Cost of Pharmacology Gaps Every experienced drug hunter knows this: validation isn’t the problem Terry puts it bluntly: “Once you have a molecule, everything boils down to pharmacology—hit, lead, candidate invaluable for mechanistic understanding—assay volume control, expression system contrasts, predictive pharmacology Corner Terry’s Corner  is a living, growing knowledge hub led by Terry Kenakin—a world authority in pharmacology

Welcome back GPCR lovers, In pharmacology, the wrong interpretation of antagonist behavior can derail This week in Terry’s Corner , we go beyond the dose-response curves to explore the kinetic and pharmacologic edge by staying on top of the latest breakthroughs in allostery, biased signaling, and computational pharmacology Keywords: GPCR, drug discovery, pharmacology, antagonism, competitive, non-competitive, Terry's Corner #DrugDiscovery #Pharmacology #Biotech #GPCRNews #Science #DrugDevelopment

GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. features a discussion about a scalable GPCR-RAMP assay. Their global resource is now helping labs decode GPCR biology at scale. It’s exciting to see how the GPCR field is evolving. GPCR Team

: insights into multireceptor pharmacology for the treatment of metabolic disease Milena Malcharek 10 - 12, 2024 | Pharmacology 2024 NEW January 13 - 16, 2025 | PepTalk 2025 NEW January 25 - 29, 2025 Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated : insights into multireceptor pharmacology for the treatment of metabolic disease The role of receptor

High-content screening (HCS) has become a cornerstone in GPCR and phenotypic drug discovery, enabling spatial dynamics, and context-dependent signaling significantly influence pharmacology. pharmacology. pharmacology. For teams working in GPCR pharmacology or cannabinoid research, these tools accelerate hit validation

Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. GPCR Ecosystem. Strong science. Promising data. But no systems to turn it into momentum. GPCR, I’m connected to 1,300+ scientists and decision-makers worldwide. Who I Work With ✅ Biotech Teams  – Especially those lacking in-house GPCR leads or overwhelmed by CRO data chaos. ✅ Venture Capital Firms  – Looking to accelerate, troubleshoot, or validate GPCR assets

Breakthroughs this week:  Potentiation of GPCR signaling by ATP and sugar monophosphates; Pharmacology mutated GPCRs. You’ll explore how catalytic control, allosteric shifts, and CYP450 behavior rewrite the rules of pharmacology Kenakin — October 30, 12 PM EST Bring your toughest pharmacology questions and join Dr. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

Target-based screening is now a fundamental pillar of drug development, and GPCRs are key targets for They provide rapid and scalable assessment of pharmacological parameters. How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Compatible with various sources of GPCRs. Contact us  to drive further advancements in GPCR drug discovery!  

Career opportunities:  Principal Scientist - In Vitro Pharmacology; Senior Scientist, Molecular Pharmacology GPCR University Course Attendee Dr. Exclusive discounts on Terry’s Corner  digital pharmacology courses Priority access to insights from GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who #DrGPCR #BindingAffinity #Pharmacology #DrugDiscovery #LeadOptimization #TerryKenakin #EmergingDrugHunter

Drugs Change the Game For decades, drug design has treated GPCRs as surface targets. GPCRs now have validated intracellular  allosteric sites. This opens up a new pharmacological space—and a reason to revisit “failed” targets with fresh eyes. Persistent binding isn’t just about longer half-lives—it’s about smarter pharmacology. pharmacology and drug discovery.

That perspective changed the moment he entered GPCR research . GPCRs demanded something different: the integration of modeling, medicinal chemistry, and pharmacology Pharmacologists know they aren’t being oversold. The GPCR Challenge What makes collaboration non-negotiable in GPCR research is the biology itself. GPCR Models Don’t Discover Drugs—People Do In GPCR research, the biggest breakthroughs won’t come from

GPCRs pose a critical challenge in drug discovery: a vast therapeutic potential with many targets yet They can also further pharmacological and structural studies, as they can be used to determine receptor This means fluorescent probes enable a dynamic observation of GPCRs. common starting point for employing fluorescent probes in GPCR assays. Fluorescent ligands: Bringing light to emerging GPCR paradigms.

Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan. From Cambridge to Leadership That early curiosity led her to pursue a PhD in Molecular Pharmacology at Luck, Leadership & GPCR Signaling Michelle is clear: luck played a role. But so did choice. GPCR Podcast 🔓 Want to go deeper? Join   Dr. GPCR Premium  for exclusive tools, deep dives, and expert access.

GPCR. pharmacology. Problem Solved:  Gain a deeper understanding of the pharmacological underpinnings of opioid overdose, GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need Access this week’s full Premium Edition here ➤ What our members say 🗣️ “The best pharmacology teacher

That’s exactly why we created GPCR Happy Hour . GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not Be Part of the GPCR Community Dr. GPCR is a nonprofit global community  dedicated to building a strong, connected GPCR ecosystem. GPCR Happy Hour is more than a social event.

of Pharmacology I & II  courses! Topics include pharmacologic activity measurement, mechanisms of action, and GPCR discovery strategies and ' Advanced Data Analysis for GPCR Pharmacology' ." Papers NEW Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Research Associate

Watch Episode 175 From failed assays to breakthroughs in GPCR modeling , Dr. With limited structural data but a growing pharmacological interest, GPCRs presented the perfect challenge Pharmacology, on the other hand, is often outsourced through collaborations with expert labs who specialize Trainees must learn how to interpret assay data, understand pharmacological context, and communicate predictive modeling matures, its role will continue to expand, guiding ligand discovery, informing pharmacology

Rethinking Affinity, A Critical Edge for Drug Hunters One of the most persistent misconceptions in pharmacology apparent affinity differences delays key milestones. 🗣️ “Thank you for bringing this (Principles of Pharmacology At Alkermes, Sokhom Pin built an in vitro pharmacology group from scratch—not just a lab, but a culture Exclusive discounts on Terry’s Corner  digital pharmacology courses Priority access to insights from Access this week’s full Premium Edition here ➤ Hashtags: #GPCR #DrGPCR #BindingAffinity #Pharmacology

We’ve made some updates to the Principles of Pharmacology I & II courses, and we can’t wait for you Here’s the refreshed schedule: Principles of Pharmacology I October 3, 10, 17, 24 Principles of Pharmacology Don’t miss out on insightful resources like '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR Pharmacology .' Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .

Apply unique pharmacologic assays and unconventional ligands to unveil GPCR activities. pharmacology concepts for practical use in academia and industry. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Summit Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every Terry’s Pharmacology Corner  delivers trusted, razor-sharp insight to help drug discovery professionals Unlock “GPCRs as Allosteric Machines” Now Only in Terry’s Corner Why Terry’s Corner Terry’s Pharmacology Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.