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Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. They stall because the data becomes a mess. GPCR Ecosystem. Strong science. Promising data. But no systems to turn it into momentum. GPCR, I’m connected to 1,300+ scientists and decision-makers worldwide. data chaos. ✅ Venture Capital Firms  – Looking to accelerate, troubleshoot, or validate GPCR assets

explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini Takeaway Forget what you think you know about GPCR drug targets. data platform , GPCR training program , pain research , opioid signaling .

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement. But precision isn’t just about clean data; it’s about interpreting what that data means. GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug later in development In this exclusive session, Kenakin gives you the frameworks needed to interpret data GPCR Premium Membership Gives You an Edge Dr.

GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. features a discussion about a scalable GPCR-RAMP assay. Their global resource is now helping labs decode GPCR biology at scale. It’s exciting to see how the GPCR field is evolving. GPCR Team

Without a solid grasp of these concepts, scientists risk misinterpreting critical data, leading to flawed Solve the problem of misinterpreting your data by understanding how slow-offset kinetics can mimic classical Avoid the professional threat of flawed data interpretations that can lead to costly dead ends and missed Gain a competitive edge by transforming your GPCR data from chaos into a strategic asset, enabling faster Bridge science and strategy:  Ensure data and decision-making align with funding and milestones.

Why I Started GPCR Consulting You've got great data. You've got brilliant scientists. The GPCR Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes of high-quality data. GPCR As the co-founder of Dr. GPCR, we've built a global hub connecting over 1,300 GPCR scientists dedicated to this field.

Target-based screening is now a fundamental pillar of drug development, and GPCRs are key targets for How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Compatible with various sources of GPCRs. and brightness will enhance assay sensitivity, while integration with artificial intelligence-driven data Contact us  to drive further advancements in GPCR drug discovery!  

Watch Episode 167 Today’s GPCR scientists don’t want to study one interaction, they want to model the The newest scientists want scalable, automated systems and the tools to move from data collection to Compatible with multiple readouts: proximity, immuno assays, pulldowns Validated antibodies + digital search platform This delivers all three.” — Tom Sakmar A Use Case for Every Angle Beyond RAMPs, this platform can study , GPCR online course , GPCR data platform , multiplex assays , GPCR drug discovery

struggled for months with crystallography, he could pull a clean protein structure from the Protein Data Assay data flows back into models. The cycle only works because every part is connected .   predictions justify immediate synthesis, and when the smartest move is to pause until better biological data Carlsson’s: modeling designed with downstream chemistry in mind, chemistry connected to assays, and assay data Why His Model Works What sets Carlsson apart is not just access to computational power or assay platforms

, multiplexed platform to investigate GPCR-RAMP biology  like never before. is that you can do many things with one pot of samples.” — Tom Sakmar Enter the Toolkit As the pilot data and an online platform to query GPCR-RAMP interaction data and antibody validations. interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr. GPCR ecosystem

GPCRs pose a critical challenge in drug discovery: a vast therapeutic potential with many targets yet Fluorescent ligands provide real-time data on receptor activation, ligand binding and downstream signaling This means fluorescent probes enable a dynamic observation of GPCRs. common starting point for employing fluorescent probes in GPCR assays. Fluorescent ligands: Bringing light to emerging GPCR paradigms.

From Platform to Pivot: The Birth of HTRF The journey to pHSense didn’t begin with a probe. It was born from radical rethinking of assay design, where platform constraints became product opportunities But the moment we got bench-level data that aligned with our design—it became a breakthrough.” — Dr. models with Jean-Philippe Pin’s lab → Breakthrough internalization data in endogenous cells expressing And this ethos continues: every product is just the beginning of a feedback loop, where customer data

That’s exactly why we created GPCR Happy Hour . GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not Be Part of the GPCR Community Dr. GPCR is a nonprofit global community  dedicated to building a strong, connected GPCR ecosystem. breakthrough tools throughout the discovery process, including its pioneering organellar electrophysiology platform

GPCR research requires turning data into insights for drug discovery Hi GPCR Friends, Every week, critical decisions in GPCR research hinge on subtle shifts in data. GPCR Podcast – Ajay Yekkirala on GPCR Innovation In this episode, Dr. Be part of the nonprofit mission to unite the GPCR community. The pace of GPCR innovation is accelerating.

Enhancing scientific exploration by concentrating on understanding inhibition to advance GPCR drug discovery This Week’s GPCR Intelligence: Every drug you design will meet an enzyme before it meets its receptor mutated GPCRs. , and concise reads on β-agonists, phospho-barcodes, and GPCR allostery. The pace of GPCR innovation is accelerating.

space focused on GPCR pharmacology. Explore her path from postdoc to platform builder.   PK/PD   Subscribe to The Kenakin Brief Fluorescent Probe CELT-419 Powers D3R Binding Assays Across Platforms GPCR Podcast appearance. GPCR Team

Hello GPCR Enthusiasts, Interpreting binding data isn’t optional—it’s career-defining. Yamina’s Corner reveals how fragmented data, undefined workflows, and ambiguous decision gates silently Stop wasting talent:  When senior leaders spend nights copy-pasting data, your burn rate accelerates Read the article now ➤ Discovery on Target - The Next Wave of GPCR Drug Discovery The 20th Annual GPCR-Based GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed.

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every You’ll see how this manifests in real data from muscarinic receptors, CCR5 chemokine programs, and NMDA Interpret probe-dependent effects Model and anticipate longer equilibration times Recognize when your data Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.

Get your space suits on, GPCR cadets! up with a series of cosmic GPCR events for the year ahead. It’s time to mark your calendars and save the dates—let’s make some stellar memories together! Discounted GPCR courses - because who doesn't love a good deal?  Classified GPCR News  Let’s dive into the   Classified GPCR News from October 28th to November 3rd, 2024

The central role of GPCRs in Neurological Disorders GPCRs are the largest family of membrane receptors Over 30% of FDA-approved drugs target GPCRs, with many targeting CNS located GPCRs. GPCR Structure, Activation, and Signaling Pathways in the Brain An understanding of GPCR structure is GPCR signaling: (A) an orthosteric ligand (orange) binds an inactive GPCR, the β2 adrenergic receptor Emerging GPCR Therapeutic Targets in CNS Drug Discovery GPCRs have been studied for decades, but there

With limited structural data but a growing pharmacological interest, GPCRs presented the perfect challenge This success was a revelation—it was possible not only to interpret experimental data but to forecast Trainees must learn how to interpret assay data, understand pharmacological context, and communicate Still, he emphasizes that data limitations remain a major challenge, especially when it comes to small Unlike protein sequences, small molecule data are often fragmented, inconsistent, or unavailable, making

Welcome GPCR Fans,   Every discovery-phase decision you make shapes your entire pipeline trajectory—and Must-read publications:  GPCRchimeraDB: Database of engineered GPCR designs. Stay ahead of competitors:  Know when your data reflects equilibrium and when to probe deeper, ensuring GPCR University Course Attendee Dr. The pace of GPCR innovation is accelerating.

Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates Design for translation:  Map sensitivity ranges to tissue contexts so your plate data predicts what happens Eric Trinquet traces how a series of bold pivots—from Cisbio’s HTRF platform to IP-One and now pHSense—reshaped how GPCR biology gets measured. GPCR innovation is accelerating.

If you’re building tools or careers in GPCR science, this is your playbook. It took data, yes—but also a deep partnership with GPCR legend Terry Kenakin to bridge industry credibility constitutive activity, agonist-induced internalization, and cellular dynamics. 🔄 What Changed After This Data GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives Discovery Program So what does that mean for discovery scientists designing the next generation of GPCR Even the most elegant GPCR ligand can fail if it never reaches its receptor. This lecture challenges scientists to move beyond binary inhibition data and embrace a systems-level Kenakin with your own enzyme or GPCR interaction puzzles.

isn't just  about the latest and best assay; it's about the framework that ensures the right assay data GPCR, we recognized this core problem. We'll look at how overlooked operational details, such as misaligned data from diverse GPCR assay types Part 2: The Data Disconnect : Discover how fragmented, unmanaged GPCR data  cripples scientific progress Learn how to build an integrated data pipeline  that transforms this chaos into a strategic asset.

GPCR , the global nonprofit platform dedicated to advancing GPCR science through education, community , and platform visibility , is proud to spotlight pHSense™ , a new reagent family from Revvity , now GPCR. GPCR  is a global nonprofit platform advancing GPCR research  through education, community, and platform assay platforms. 🔍 Learn More → Listen to the Podcast with Revvity’s Eric Trinquet → Explore the pHSense

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target GPCR Kinetics: The Critical Data You Can’t Afford to Skip Equilibrium potency data only tells part of “GPCRs are nature’s prototype allosteric proteins. Everything they do is allosteric.” Kenakin with your own enzyme or GPCR interaction puzzles. This AMA helps you read that story faster, so you don’t just generate data—you generate direction. 🟢

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing This week, we focus on how to convert ambiguous data into confident, defensible Mechanism of Action calls—before Career opportunities:  Research Assistant; Postdoctoral Associate; Senior Scientist, Data Science—curated GPCR scientists, translational pharmacologists, biotech discovery teams, platform company leaders, and community platform to help train and inspire the next generation of scientists.