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How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Ligands Looking ahead, fluorescence polarization technology is expected to expand its role in GPCR research

Why Purpose Matters in Science For some researchers, science is a job. For others, it’s a calling. , Catherine reflects on how her identity as a scientist took shape, why she’s committed to academic research That alignment between curiosity and urgency set her on the path toward doctoral research. What’s Next in Her Opioid Research Catherine’s current experiments focus on outcomes such as respiratory Catherine’s story shows that when purpose drives research, science becomes more than a job—it becomes

July 2022 Cancer Research UK and Sosei Heptares sign agreement to advance cancer immunotherapy candidate into clinical trials "HTL0039732 is a novel EP4 antagonist with potential to treat a wide range of cancers biopharmaceutical company and world-leader in GPCR1-focused structure-based drug design (SBDD) and development, and Cancer Research UK, the world’s largest private funder of cancer research, today announce the signing of an agreement to bring Sosei Heptares’ cancer immunotherapy drug candidate into a first-in-human trial."

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding microenvironment. A finely tuned signalling compartmentalization orchestrated in dynamic platforms is an essential requirement for the proper and efficient response of these cells to distinct triggers. During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains in controlling signalling compartmentalization during T cell activation and functions. Here, we discuss mechanisms responsible for signalling amplification and compartmentalization in T cell activation, focusing on the role of CD28, chemokine receptors and the actin cytoskeleton. We also take into account the detrimental effect of mutations carried by distinct signalling proteins giving rise to syndromes characterized by defects in T cell functionality." Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "August 10, 2022 Cancer Research UK is working with global biopharma Sosei Heptares on a treatment they hope will bring immunotherapy benefits to new cancer types. Cancer Research UK, a charity dedicated to funding lifesaving oncology research, spent £388 million on cancer research last fiscal year. Much of that funding is distributed to support third party research, but the group also does its own

Watch Episode 170 Thinking Differently Pain research has long followed a familiar route: from molecule Why This Approach Matters In pain research, bottom-up approaches often fail to translate. It asks researchers to consider the entire ecosystem: from patient to molecule , not just the other way Alex Serafini makes the case for building pain research from the clinic down, not the bench up. _____ ___ Keyword Cloud: GPCR podcast , pain modeling , GPCR online course , translational research , neuroimmune

activity biosensors Marta Lopez-Balastegui, Antonella Di Pizio, Jiafei Mao, Jana Selent, et al. for their research Join fellow scientists and researchers in person to stay updated with adhesion GPCR biology. specifically activated by ACP (adipokinetic hormone/corazonin-related peptide) GPCRs in Oncology and Immunology and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Methods & Updates in GPCR Research - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Research

August 2022 "We are proud to announce that SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher Education and Research for 2022-2023-2024. #technology #lifescience #immunology #antibodies #medicine #cancer #innovation #gpcr #synabs #monoclonalantibodies #drugdiscovery #biotechnology #research #ionchannels #biologics #biotech #pharma #pharmaindustry #pharmaceuticals

November 2021 "So proud and grateful to receive honorary doctorate yesterday from Karolinska Institute

Drum rolls, we’ve got 15 GPCR research papers, updates, industry news events, and GPCR ads curated just in downstream pathway activation Chiara D Mancinelli, Joshua Levitz, David Eliezer, et al. for their research It is an opportunity to connect with like-minded scientists and researchers and gain valuable insights Neuronal GPCR NMUR-1 regulates energy homeostasis in response to pathogen infection GPCRs in Oncology and Immunology Reviews, GPCRs, and more Lessons from the physiological role of guanosine in neurodegeneration and cancer

August 2022 "The atypical chemokine receptor 1 (ACKR1) was discovered on erythrocytes as the Duffy blood group antigen ( Cutbush et al., 1950 ), also called Duffy-antigen/receptor for chemokines, or DARC ( Novitzky-Basso and Rot, 2012 ). Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation. Accordingly, within the erythroid lineage ACKR1 expression occurs first and is the highest in erythroblasts ( Duchene et al., 2017 ). Additionally, ACKR1 expression characterizes venular endothelial cells (ECs) ( Pruenster et al., 2009 ; Thiriot et al., 2017 ), including those lining bone marrow (BM) sinusoids ( Duchene et al., 2017 ). This well-established, distinctive pattern of cell expression has been directly challenged by a publication purporting ACKR1 expression in mouse BM by macrophages, but not erythroblasts and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 on hematopoietic stem cells (HSCs) to maintain their quiescence ( Hur et al., 2016 ). In light of the extensive literature, these findings have been particularly provocative, as this was the first description of ACKR1 expression by any leukocyte type and, if correct, would change current concepts of ACKR1 involvement in pathophysiology. The reported ACKR1 expression by macrophages in Hur et al. relied on using commercial anti-ACKR1 antibody FAB6695, which has neither been validated by the manufacturer nor by the authors. This prompted us to investigate the specificity of FAB6695 and scrutinize the apparent ACKR1 expression in BM macrophages" Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein

multiple roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer

Embark on another exciting exploration of the unknown realms of GPCR research. Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Scientist, GPCR Pharmacology Research phosphate receptor subtype 1 (S1P1) activity in the course of Alzheimer's disease GPCRs in Oncology and Immunology transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research

This makes it an ideal candidate for GPCR research, where accuracy in detecting subtle signaling changes Enhancing HTRF Assay Performance in GPCR Research Using Fluorescent Ligands GPCRs are involved in numerous By using donor-acceptor pairs with different emission spectra that don’t overlap, researchers can design technologies by providing high-performance fluorescent ligands designed specifically for pharmacological research

Some Nbs that have been use for GPCR research are: Nb80: This nanobody stabilized an active-state conformation Nb7: This nanobody improves the diffraction quality of the constitutively active GPCR US28·CX3CL1 complex5

August 2022 "Bone remodeling is precisely regulated mainly by osteoblasts and osteoclasts. Although some G-protein coupled receptors (GPCRs) were reported to play roles in osteoblast function, little is known about the roles in osteoclasts. In this study, we found, for the first time, that the expression of GPR110 increased during osteoclastogenesis. GPR110 belongs to adhesion GPCR and was the functional receptor of N-docosahexaenoyl ethanolamine (also called synaptamide). Synaptamide suppressed osteoclastogenesis induced by receptor activator of nuclear factor-kappa B ligand. Considering that synaptamide is the endogenous metabolite of DHA, we hypothesized that DHA may inhibit osteoclastogenesis by affecting synaptamide/GPR110 signaling. But GPR110 knockout and subsequent rescue experiments revealed a pivotal role of GPR110 in the attenuation of osteoclastogenesis by synaptamide but not by DHA. These results suggest that synaptamide/GPR110 signaling negatively regulates osteoclastogenesis. Our study suggested that ligands of GPR110, such as synaptamide, might be a useful drug for osteoporotic patients." Read more at the source #DrGPCR #GPCR #IndustryNews

Embark on another exciting exploration of the unknown realms of GPCR research. The 11th Adhesion GPCR Workshop 2024 was a successful event that brought together experts, researchers Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research phosphate receptor subtype 1 (S1P1) activity in the course of Alzheimer's disease GPCRs in Oncology and Immunology promotes transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research

After all, a good tool makes a good assay, and a good assay improves research capacity. Chemistry Tools session was more industry focused than those before, and Maria shared the floor with researchers

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology , CEO of Celtarys Research. About Celtarys Research Celtarys Research is a biotech company based in Spain that specializes in the

the dual A2B/A3 adenosine receptor fluorescent antagonist (CELT-327) was added to HCT116 cells (colon cancer Our scientific team can guide you choose or design the right fluorescent ligand for your research.   Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands

Eric Trinquet, Director of Research and Development at Revvity.   A GPCR Internalization Tool Designed for Real Research Needs Built on more than two decade A GPCR Internalization Tool Designed for Real Research Needs s of GPCR assay innovation , pHSense™  was developed to overcome GPCR  is a global nonprofit platform advancing GPCR research  through education, community, and platform Its GPCR research tools  support discovery teams and academic labs with precision reagents and validated

A Detour Through Immunology Her growing interest in addiction led her to the NIH’s Perinatology Research to patient-centered research. “It really forced me to kind of patch up all my immunology holes and then apply them. I came away from that job with just a whole new appreciation for immunology and for pregnancy. The Importance of Passion in Research Catherine's journey highlights the importance of passion in research

August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs). Several integrins directly modulate VSMC contraction by regulating calcium influx through L-type voltage-gated Ca2+ channels (VGCCs). Genetic variants in ITGA9, which encodes the α9 subunit of integrin α9β1, and SVEP1, a ligand for integrin α9β1, associate with elevated blood pressure; however, neither SVEP1 nor integrin α9β1 has reported roles in vasoregulation. We determined whether SVEP1 and integrin α9β1 can regulate VSMC contraction." Read more at the source #DrGPCR #GPCR #IndustryNews

Summit 💲 Special Pricing on GPCR courses GPCR Forum Start a lively chat or request help with your research caused up to 20% weight loss after a year, with no plateau INAUGURATION OF AELIS FARMA NEW LABORATORY at Institut Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research kappa opioid receptors in a heterologous system and in primary striatal neurons GPCRs in Oncology and Immunology ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Methods & Updates in GPCR Research

The GPCR ship is setting sail on a grand voyage across the vast ocean of research. Symposia 💲 Discounted GPCR courses GPCR Forum Start an engaging discussion or request help in your research Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics GPCRs in Oncology and Immunology hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase Methods & Updates in GPCR Research

In a recent study on TAAR1, a GPCR linked to central nervous system disorders, researchers compared the

receptor activity-modifying proteins Nicholas Kapolka , Geoffrey Taghon , and Daniel Isom  for their research Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators GPCRs in Oncology and Immunology protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Methods & Updates in GPCR Research Clinical Pharmacology GPCR Jobs NEW Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research

occurring Δ9-tetrahydrocannabinolderivatives to cannabinoid CB1 and CB2 receptors, Pharmacological Research

August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated receptor (PPAR) α/γ agonist saroglitazar, has been approved. Here, we sought to investigate the role of Regulator of G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. " Read more at the source #DrGPCR #GPCR #IndustryNews