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Results found for "Martha Summer"
- Dr. Marta Filizola - Dr. GPCR Podcast
Marta Filizola! Subscribe to the podcast today and get notified when new episodes are released!
- 📰 GPCR Weekly News, May 15 to 21, 2023
Marta Filizola. Check it out! The Dr.
- Exploring the Breakthroughs in GPCR Research
work on Get ready to sharpen your tools:A short guide to heterotrimeric G protein activity biosensors Marta
- Understanding Enzyme Inhibition In GPCR Discovery Programs
Read the Feature ➤ Summer Days: Appetite, Suntans, and GPCR Micro-Domains Two recent papers connect ciliary
- From Failed Experiments to Predictive GPCR Models
A summer spent purifying proteins highlighted his discomfort at the bench.
- 📰 GPCR Weekly News, July 17 to July 23, 2023
GPCR Events, Meetings, and Webinars NEW Summer GPCR Zoominar session (July 27, 2023).
- Advancements in G protein-coupled receptor biosensors to study GPCR-G protein coupling
Here, we briefly summarize a subset of this field with accelerating importance: transducer biosensors
- Function and structure of bradykinin receptor 2 for drug discovery
In this review, we summarize the structure and function of B2R in relation to drug discovery and discuss
- G protein-coupled receptor signaling: transducers and effectors
We will first summarize their prominent roles in GPCR pharmacology before transitioning into less well-explored
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
We summarize recent discoveries that have advanced our understanding of rod outer segment (ROS) morphology
- G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological
- Posttranslational modifications in GPCR internalization
Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in
- Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
In addition, we summarize current strategies for the identification of allosteric sites as well as ligand-based
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
We now summarize important pharmacological, molecular, and cellular studies relevant to D1-mediated β-arrestin-related
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
In this review, we discuss both the ‘friend’ and ‘foe’ features of TGR5 by summarizing its tumor-suppressing
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
protein-coupled receptors in the regulation of cardiovascular system function and the drug target exploration, we summarize
- GRK2 in cardiovascular disease and its potential as a therapeutic target
GPCRs, describes the structure and functions of GRK2 in cardiac function and maladaptive pathology, and summarizes
- Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and ...
Here, we summarize evidence that supports these conjectures, fostering new ideas about the physiological
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
Latorraca, N.R., Wang, J.K., Bauer, B., Townshend, R.J.L., Hollingsworth, S.A., Olivieri, J.E., Xu, H.E., Sommer
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
The PROcisionXᵀᴹ platform (summarized in Figure 2) can be used to complete a discovery campaign within
