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<< Back to podcast list Strategic Partner(s) Murat Tunaboylu & Ben Holland About Murat Tunaboylu "Murat Tunaboylu, Antiverse's CEO, has a software engineering and bioinformatics background. After switching to biotech, Murat has built cell imaging software and lab robots to accelerate cancer Murat Tunaboylu on the web Antiverse DSV Future of Drug Discovery Podcast Twist Bioscience LinkedIn Twitter

Murat Tunaboylu, CEO Antiverse Before engaging Yamina, our team faced hurdles navigating complex early

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Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung cancer-mutations

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Mutations in aGPCRs have been linked to various neuropsychiatric phenotypes, and my work will provide

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This is a rare neurodevelopmental disorder caused by de novo mutations in the GRIN genes that encode

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The adapter protein 3BP2 is mutated in Cherubism.

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Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb

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Abstract "Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome caused by a germline mutation Glioblastoma (GBM) is the most prevalent central nervous system tumor in LFS, with TP53 mutations detected that ADGRB3 functions as a tumor suppressor in the brain, and its silencing, in the context of p53 mutation flexibility of GAIN flaps affects aGPCR function under native conditions, we strategically inserted specific mutations

2012 from the University of Oxford, where her research focused on the cellular mechanisms by which mutations

cancers, BAI1-3 expression can be lost through epigenetic silencing, copy number loss or truncating mutations WNT pathway activation in WNT-MB is driven by mutations of the CTNNB1 gene, activating ß-catenin-dependent GAIN-targeted antibodies, and cancer-associated mutations at the GAIN-7TM interface, alter holoreceptor

analysis of cancer drivers by co-developing GECCO, an algorithm for the identification of noncoding mutations He highlighted their interest in non-coding mutations in promoters and the 3'UTR region important for

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During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the

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Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung cancer-mutations

Mutational experiments on residues of interest showed that restoring the Phe-His interaction in the uncleaving

.” – Alessandro Nicoli He emphasized that MD allows researchers to observe allosteric changes , mutation

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