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Timo De Groof About Dr. Timo De Groof Dr. Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in During his last year of studies, Timo performed research in the biopharmaceutical company Argen X and During his Ph.D., Timo, together with Dr. Timo De Groof on the web LinkedIn Researchgate Twitter Medical Imaging Group Google Scholar Dr.

Workshop 2024 , hosted in the vibrant heart of Mexico City at the prestigious venue, CINVESTAV - Centro de Investigación y de Estudios Avanzados del IPN (in English: Center for Research and Advanced Studies About the venue Cinvestav: Centro de investigación y de Estudios Avanzados del IPN Av. Preliminary Program Layout Date Time Title October 23, 2024 October 24, 2024 October 25, 2024 *Flash

The conversation covers the de-orphanization of GPR139 and GPR55, the unresolved promise of biased agonism His group contributed to the de-orphanization of GPR139 and GPR55, including the identification of sub-nanomolar GPCRDB as community infrastructure for integrating and accelerating GPCR research The interdisciplinary de-orphanization De-Orphanization Is a Full-Discipline Effort The process of characterizing an orphan receptor from protein sequence data 11:55 Orphan GPCRs - years spent chasing receptors with no known function or ligand 13:31 De-orphanizing

and risk 16:18 Turning down the medical school acceptance — 25 years of no regrets 22:10 Université de Gaetan Guillemette in the Pharmacology department at the Université de Sherbrooke. Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN). He also actively volunteers as an Associate Professor of the non-governmental organization Institut des Sciences, des Technologies et des Etudes Avancées d’Haïti (ISTEAH) to help consolidate higher education

biochemists Celtarys empowers medicinal biochemists by providing innovative fluorescent probes that de-risk She then joined the University of Santiago de Compostela as a postdoctoral researcher in Prof. and Celtarys Research Join Forces to Expand Access to Innovative GPCR Tools Boston, MA and Santiago de Fluorescent Probes Innovative fluorescent probes that de-risk the pre-clinical drug discovery phase with Mestre Mateo 2, Santiago de Compostela, 15706, Spain Email Website LinkedIn

ABOUT THE GUEST Michel Bouvier is CEO of the Institut de Recherches Cliniques de Montreal (IRCM) and He completed his PhD under Jacques de Champlain, studying the role of presynaptic adrenergic receptors Bouvier returns to throughout his career, originally from Julie Axelrod via his PhD mentor Jacques de and a scholar of the Medical Research Council of Canada at the Faculty of Medicine of the Université de As some of you may know, Michel was one of my professors at the Universite de Montreal.

Most importantly, the GPCR Retreat dedicates time for two trainee symposia, an initiative that began Conference History The GPCR Retreat is an annual joint meeting with the Club des récepteurs à Sept Domaines The following year, the Great Lakes GPCR Retreat partnered with the annual symposium of the Club des Montebello, the 22nd Annual Great Lakes G Protein-Coupled Receptor Retreat held jointly with the Club des

Fuel Discovery VC Due Diligence & De-risking For Venture Capital Firms De-risk GPCR Investments: Identify focused, scientific expertise that accelerates complex GPCR discovery programs, ensuring clarity and de-risking This ensures robust, defensible decisions that de-risk your program from early discovery to regulatory delivering high-quality data across complex biotech programs, but translating that data into aligned, timely

Bianca Plouffe obtained her B.Sc. in Biochemistry in 2003 from Université de Sherbrooke (Qc, Canada). In 2006, Bianca obtained a Doctoral Scholarship from the Fonds de Recherche du Québec en Santé. Institutes of Health Research in 2012, Bianca joined the research group of Prof Michel Bouvier at Université de

Every time, it’s a new world—and we’re still learning.” — Maria Majellaro Through this partnership, Celtarys She began as a medicinal chemist in Italy, but a postdoc opportunity in Santiago de Compostela—and a mentor’s timely suggestion—changed her trajectory. When the time came to decide whether to leave the lab and lead Celtarys into biotech, she took the leap predoctoral visiting student at the CIQUS Research Center—Campus of International Excellence—in Santiago de

with our nonprofit team for expert guidance, trusted CRO collaborations, and field-tested tools that de-risk From pipeline acceleration and investment de-risking to CRO differentiation — turning GPCR complexity Book a Strategy Call → Our Core Support Areas Discovery Consulting & Strategy Expert guidance to de-risk

Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke Doctor of Philosophy (Ph.D.) in biochemistry under the supervision of Michel Bouvier at Université de

an opioid receptor pharmacology group at the CHU Sainte-Justine Research Center and the Université de Research Center and a professor in the Department of Pharmacology and Physiology at the Université de She completed her PhD at McGill University with Claude de Montigny, working on serotonin and antidepressant mechanisms, and her postdoctoral training with Michel Bouvier at the Université de Montréal, where she

receptors at the bench — training that spanned chemokine receptor conformational dynamics at the Université de collectively underserved by the infrastructure around it, and building that infrastructure has become a full-time She holds a PhD in Biochemistry from the Université de Montréal, where she trained in Dr. "Brian throughout his career was told so many times that he should quit science.

"My contribution to science began during the equivalent of U.S. masters training at the Université de During this time, Dr. Sebag as an exchanged scholar while my student visa was in the work, during which time I thoroughly reviewed At the time, NanoBiT was a prototype technology we gained access to by collaborating with Promega. I also invested a tremendous amount of time in developing my leadership skills.

stall timelines without payoff Match experiments to the specific phase and risk tolerance of the asset De-risk Your CRO Strategy I evaluate, select, and manage CROs that are fit-for-purpose—saving you time, cost

From Many to One: De-Orphanization and Precision Focus “You can use this system to de-orphanize receptors

Brian Kobilka's lab at Stanford University and the SFMB laboratory at the Université Libre de Bruxelles

He obtained his Ph.D. from the Université de Montréal in 2002 under the guidance of Dr.

Aurélien Rizk co-founded Algorizk, a company that created real-time physics simulations for education in mathematics, physics, and computer science at the French Grande École, École Normale Supérieure de They highlighted that while there was a time when biology lagged due to the lack of appropriate tools Technology Evolution and Ligand Residence Time Prediction Yamina Berchiche and Aurelien Rizk discussed The conversation also revolved around the company's ability to predict the residence time of a ligand

This gap is one of the defining bottlenecks in receptor pharmacology, and closing it one receptor at a time Bender's work targets this gap directly - arguing that de-orphanizing a receptor biochemically and making Bender credits his time at the bench with preventing the kind of over-interpretation that models built "Taking time to think about what you're doing is way more valuable than just trying to do the next ten

Monitor GPCR internalization in real time with pHSense™ – no-wash, TR-FRET reagents from Revvity. Unlock microscopy-free real-time GPCR internalization with pHSense pHSense™ probes are optimized reagents for plate readers, specifically designed to study internalization using time-resolved fluorescence ( Time-Resolved Fluorescence (TRF) = High Signal-to-Background: Europium’s long-lived fluorescence allows degree in biology and biotechnology engineering from the University of Sciences of Nîmes and the Ecole des

His postdoctoral training included research at the École Polytechnique Fédérale de Lausanne (2015–2016

Scientific Officer and co-founder of Celtarys Research , a biotech spin-off from the University of Santiago de

There was no proof they were physically distinct molecules. SCIENTIFIC THEMES OF THE CONVERSATION The receptor hypothesis before proof — The conceptual and experimental Exact times may vary slightly from the published recording. 00:00 Introduction 01:29 How Dr. And I remember thinking to myself as a young buck at the time: I'm going to show this guy. It took a hell of a long time."

Brian Blagg at Notre Dame on β-and-GRP94-selective compounds has produced proof-of-concept IV data that John started grad school in 1999 and spent some time figuring out what he was interested in.

development leader with extensive experience driving drug discovery teams in bringing biologics to clinical proof

How receptor residence time — not affinity — rescued a CRF drug discovery program, and why a career in the math never captured. << Back to podcast list Strategic Partner(s) Sam Hoare: Receptor Residence Time His current work extends that logic into signaling kinetics: the time dimension in GPCR signaling that — and why affinity alone is insufficient Signaling kinetics: quantifying the time dimension of GPCR To me, that's what we've been doing with time-course signaling data."

Endpoint Assays Can Miss the Biology Entirely A single measurement at a fixed time point collapses all The problem is not the assay format itself; it is the assumption that one time point is enough. 2. Pfleger challenges a silent assumption embedded in most of them: that the time point chosen for each kinetics 29:44 Bias signaling as a time-dependent measurement 32:26 Screening receptors in complexes A lot of the time you get a signature, and you can compare those signatures and see a lot of nuance."

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