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Sudarshan Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology' Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia' Carole Daly

Jianming Han, Tao Che for their analysis of GPCR-G protein selectivity revealed by structural pharmacology Yao Lu, Drs Christopher Langmead,  Gregory Stewart, et al. for their study on Molecular insights into orphan

proteins (Gether 2000), with numerous intermediate sub-states in between (Vauquelin and Van Liefde 2005; Yao 1984 (Cerione et al. 1984), where reconstitution of purified β2-adrenergic receptors from guinea pig lung

August 2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling We found that preincubation and luminescence reading at room temperature were optimal as compared to

After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case Reference Cam Sinh Lu. (2024, September 3).

factors, including ETS, c-Jun, and Fos, modulating gene expression and influencing cellular functions (Lu Lu, N., & Malemud, C. J. (2019). S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003).

This Week’s Highlights: Congrats to: Our contributor, Cam Sinh Lu ,  who has just released an incredible team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M Payne ,   Cam Sinh Lu

Jang W, Senarath K, Feinberg G, Lu S, Lambert NA.

This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu

This week's highlight includes congrats to: Cam Sinh Lu, for his first Dr.

TM7 and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu constitutively active receptors, meaning they can signal independently of agonist (Casarosa, Bakker et al. 2001, Luker recycling of chemokines without activating G-protein pathways (Randolph-Habecker, Rahill et al. 2002, Luker

IJMS   2020 , 21 (14), 5064. https://doi.org/10.3390/ijms21145064 . (7)         Lu, D.; Immadi, S. 324–335. https://doi.org/10.1038/s41401-018-0164-x . (8)         Gado, F.; Di Cesare Mannelli, L.; Lucarini 376  (3), 235–242. https://doi.org/10.1056/NEJMoa1610300 . (10)      Rosado, T.; Gonçalves ,Joana; Luís

A standard format of GPCR biosensors incorporates a luminescent tag on the G protein Gα subunit and Gβγ Modifying G proteins with luminescent tags as used in biosensors altered the G protein coupling profiles R luc: Renilla  luciferase, GFP: Green Fluorescent Protein. Wouters OJ, McKee M, Luyten J. Lu S, He X, Ni D, Zhang J.

Jack Antel to its clinical advisory board Crinetics Pharmaceuticals First Quarter 2023 Earnings: Revenues

Unlike fluorescent methods, aequorin produces luminescent signals with very low background noise and This allows researchers to perform either fluorescent or luminescent calcium measurements depending on Calcium dose response curve in luminescence mode for the ChemiBRITE GLP-1 Receptor Ready-to-Assay Frozen

changes intracellular cAMP, detected through an enzyme fragment complementation readout that produces a luminescent β-arrestin recruitment to the activated receptor, bringing two enzyme fragments together to produce a luminescent

In this proximity-based approach, a NanoLuc®luciferase   genetically fused  to the target protein   transfers

In research, including the GPCR world collaboration isn’t a luxury. It’s survival.

The Quick Glance: pA₂ as Shortcut Sometimes, discovery projects don’t have the luxury of full curve analyses

This wasn’t luck. It was designed. “There was a bit of luck,” she admits. But luck alone doesn’t sustain an ecosystem. What mattered was how leadership leveraged luck into durable structure  — through funding strategies, It’s a competitive advantage. 🎧 Listen to the full episode:   Leadership, Luck, and GPCR Signaling 🔓

Leadership, Luck, and the Lab The episode isn’t just about technology — it’s also about how careers are

Luck, Leadership & GPCR Signaling Michelle is clear: luck played a role. But so did choice. It’s easy to call it luck. But luck only works if you say yes when the door opens.

This success was not mere luck.

Pipeline efficiency isn’t luck—it’s literacy.

It wasn’t luck. It was persistence.

challenges Decades of insight distilled  into frameworks you can apply immediately Pipeline efficiency isn’t luck—it

Luc Van Hijfte and Dr. Wendy Young.

This is Lucía from the Celtarys Research chemistry team. 

outputs into a central hub — where QC, analysis, consumption and consolidation across assays — isn’t a luxury

“The first time I wore my lucky cactus shirt to a major meeting... and it led to a game-changing collaboration