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pain following repeated surgeries for a pilonidal cyst. pain research at Hopkins and later an MD-PhD at Mount Sinai. pain after three weeks, an effect rarely observed. Venetia Zachariou's lab to study the effects of chronic pain and addiction/withdrawal on the mesocorticolimbic pain and affective comorbidities.

GPCR Title: Characterization of Novel Opioid-Neurotensin Bifunctional Ligands Designed to Target Pain interested in characterizing novel G protein-coupled receptors (GPCRs) ligands for the treatment of chronic pain but also in deciphering cellular signaling pathways associated with the physiological effects observed

“We’re enhancing the powerful pain-relieving effects of opioids while limiting respiratory depression He is particularly excited by the novel application of PAMs in chronic and neuropathic pain models , Discovering breakthrough results in neuroma pain models via a spontaneous collaboration. pain and opioid use disorder. pain.

Biotech founder Ajay Yekkirala shares how AI, GPCRs, and bold questions are driving next-gen pain therapeutics breakthrough GPCR research career The inside story behind founding Blue Therapeutics and targeting supraspinal pain Woolf at Boston Children’s Hospital and Harvard Medical School, where he deepened his understanding of pain Driven by the opioid crisis and the lack of non-addictive pain treatments, Ajay co-founded Blue Therapeutics , a biotech startup focused on targeting supraspinal GPCRs for chronic pain.

Nigel Bunnett at the NYU Pain Research Center as a postdoctoral researcher. research focuses on investigating GPCR signaling and trafficking in the context of inflammation and chronic pain. Next Steps Badr will continue focusing his research on GPCRs involved in pain and inflammation during Badr shared his passion for GPCR signalling and regulation, specifically in the context of pain and inflammation

studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes, chronic pain and addiction.

studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes, chronic pain and addiction.

studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes, chronic pain and addiction.

At McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to chronic stress and depression and; 2) Understand the role of phenotypically defined subpopulations of

At McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to chronic stress and depression and; 2) Understanding the role of phenotypically defined subpopulations

Join me and learn more about how Kari studies GPCRs in basal ganglia circuits following chronic alcohol

at the University of Bonn, Germany, working initially on the role of prostaglandin receptor EP4 in chronic

characterized the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic

has evolved to encompass their roles in regulating immune cell response to acute cardiac injury or chronic

Ian Chronis on the Dr. Ian Chronis In this episode, we welcome Dr. Ian Chronis, a recent Ph.D. graduate preparing to begin his postdoctoral work at the University of Michigan About Ian Chronis I recently finished my PhD in the lab of Dr. Ian Chronis on the web LinkedIn Enjoying the Dr. GPCR Podcast? Leave a Review.

published seminal papers where he used various approaches to describe the role of opioid receptors in pain Dr Gendron is co-director of the FRQS-funded Quebec Pain Research Network and the Editor-in-Chief in

ADGRC3 are required for the restoration of glutamatergic synapses in prefrontal cortical neurons of chronically

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of opioid receptors and is currently focusing on the pharmacology of cannabinoids in the context of pain

conjugates to target GPCRs, with a focus on receptors relevant for treating osteoporosis, diabetes, and pain During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the

characterization of the pharmacological properties of cannabinoids in conjunction with terpenes for pain

Classified GPCR News Let’s dive into the Classified GPCR News from February 10th to 16th, 2025 Industry News Pain administration in spinal cord injury GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain Neuroregeneration , EPSC , GLT-1 , GPR37L1 , SPM , astrocytes , maresin 1 , microglia , nerve injury , neuropathic pain

conjugates to target GPCRs, with a focus on receptors relevant for treating osteoporosis, diabetes, and pain

Terry Kenakin’s unique course, Development of GPCR Ligands as Therapeutic Drugs , and gain essential GPCRs in Neuroscience Cortical astrocyte activation triggers meningeal nociception and migraine-like pain

next career step took her to AstraZeneca as a postdoctoral trainee, where she studied animal models of pain

neurons), Vollum Institute Portland (visiting scientist with Ed McCleskey, sensory neuron properties); Pain

passion, I recently started a postdoctoral fellowship to study the role of GPCRs in the mechanisms of pain

Our first main research aspect is the identification of endogenous ligand of GPCRs. Our second main research aspect is dissecting the molecular mechanism underlying sensation of force, Our third main research aspect is working mechanism of GPCR. Our fourth main research aspect is ligand coding mechanisms and structural aided drug discovery of GPCR

Full Agenda Session V Structural mechanisms of AGPCR signaling and function Structural Determinants Of GAIN Unveiling the GPS Cleavage Mechanism in ADGRL1 with QM/MM Florian Seufert Structural Determinants Of GAIN ADGRs are autoproteo-lytically cleaved at the GPCR proteolysis site (GPS), an HXS/T motif within the GAIN We de-termined the crystal structure of the human ADGRB2/BAI2 hormone receptor (HormR) and GAIN domains domain partially re-instates cleavage, while its deletion reduces cleavage in the ADGRL1 GAIN domain

Mike's lab has two main areas of interest: 1) alternative polyadenylation as a targetable driver of pancreatic He shared that his interest in science originated from a young age and his desire to gain more knowledge However, he decided to undertake another postdoc to gain more experience and confidence. The conversation ended with Yamina expressing interest in learning more about Mike's two main research