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Fluorescent Probes: Differences in Binding Assays Fluorescent ligands are a type of fluorescent probes General structure of a fluorescent ligand. Fluorescent ligands can be used at a broader range of concentration without losing accuracy, as well Fluorescent ligands: Bringing light to emerging GPCR paradigms. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.

August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors Here, we report the structure-based development of fluorescent ligands targeting the intracellular allosteric previously reported intracellular CCR2 antagonists, several tetramethylrhodamine (TAMRA)-labeled CCR2 ligands By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well as Thus, our small-molecule-based fluorescent CCR2 ligand 14 represents a promising tool for future studies

We first synthesized a fluorescent ligand enabling equilibrium and kinetic binding studies via NanoBRET as well as fluorescence microscopy.

We have a catalogue of over 30 fluorescent ligands for different families of GPCRs, including adenosine Post not marked as liked 4 Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors Celtarys develops fluorescently labeled ligands designed for real-time, non-radioactive GPCR assays—enabling Custom Development Customized fluorescent ligands developed in less than 3 months with optimal properties Product Catalog GPCR Ligands Our GPCR fluorescent ligands are the ideal solution for your High Throughput

At Celtarys, the focus is on enabling fast, customizable development of fluorescent ligands and chemical ligand development. “You can have a great ligand—but if you can’t solubilize it, it’s useless.” — Maria Majellaro Celtarys Their approach is highly consultative—they don’t just sell ligands, they co-develop solutions. GPCR ecosystem , GPCR drug discovery , fluorescent ligands , GPCR scientist network , custom ligand development

protein-coupled receptor kinetics, signaling, and trafficking and on using novel imaging techniques, such as fluorescent ligands and complementation methods, to investigate the underlying mechanisms.