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  • Radioligands vs. Fluorescent Ligands: Binding Assays

    Fluorescent Probes: Differences in Binding Assays Fluorescent ligands are a type of fluorescent probes General structure of a fluorescent ligand. Fluorescent ligands can be used at a broader range of concentration without losing accuracy, as well Fluorescent ligands: Bringing light to emerging GPCR paradigms. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.

  • Optimizing HTRF Assays with Fluorescent Ligands: Time-Resolved Fluorescence in GPCR Research

    Enhancing HTRF Assay Performance in GPCR Research Using Fluorescent Ligands GPCRs are involved in numerous ligands. This also improves detection of low affinity or slow binding ligands. This assay utilized our fluorescent ligand, CELT-335 , designed for hCB 1 /CB 2  cannabinoid receptors ligands designed specifically for pharmacological research.

  • High-Content Screening for GPCR Programs: Overcoming Assay Limitations with Fluorescent Ligands

    binding assays—especially those enabled by next-generation fluorescent ligands—support:  Repeated imaging How Fluorescent Ligands Strengthen HCS Assays: The Case of CELT-331 Fluorescent ligands are now considered Key scientific advantages include: Physiological Relevance Fluorescent ligand binding occurs in intact Visual + Quantitative Data Fluorescent ligand assays generate both numerical values (IC₅₀, Kᵢ) and spatial As shown through the CELT-331 case study, fluorescent ligand–enabled HCS workflows provide physiologically

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