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We have a catalogue of over 30 fluorescent ligands for different families of GPCRs, including adenosine Celtarys News & Updates C5aR Fluorescent Ligands: Need for new Research Tools GPCRs are one of the most Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology “We’re thrilled to partner with Celtarys and introduce their high-performance fluorescent ligands to Product Catalog GPCR Ligands Our GPCR fluorescent ligands are the ideal solution for your High Throughput

< Back to Webinars Fluorescent Probes for GLP-1R and GIPR Imaging: From Cell Assays to In Vivo Systems His group focuses on the development of chemical tools — including fluorescent ligands and photopharmacological The company's portfolio is built around high-affinity, selective fluorescent ligands for GPCRs, supporting Broad GPCR fluorescent ligand portfolio across multiple receptor families Fluorescence Polarization, services using proprietary probes in living cells Custom chemical development for probe and ligand creation

Discover how Celtarys Research is transforming GPCR assay development with fluorescent ligands in this At Celtarys, the focus is on enabling fast, customizable development of fluorescent ligands and chemical ligand development. “You can have a great ligand—but if you can’t solubilize it, it’s useless.” — Maria Majellaro Celtarys Their approach is highly consultative—they don’t just sell ligands, they co-develop solutions.

protein-coupled receptor kinetics, signaling, and trafficking and on using novel imaging techniques, such as fluorescent ligands and complementation methods, to investigate the underlying mechanisms.

Pharmacology, Biased Signaling & Mechanistic Clarity The Real Cost of Strategic Overload in Biotech C5aR Fluorescent Ligands: Need for new Research Tools Integrated GPCR Drug Discovery: A Structured Framework for Modern

His team develops fluorescence-based and chemically engineered tools to study gpcr internalization and ligand engagement in intact islets and neuronal circuits — insights that inform next-generation functional signaling in metabolic tissues What collaborative chemistry enabled in designing receptor-targeted fluorescent ligands The moment when structural and imaging evidence clarified unexpected glucagon-derived peptide

Chemical biologist Johannes Broichhagen reveals how fluorescent probes transform GPCR imaging, internalization Johannes Broichhagen shares how his lab builds next-generation fluorescent probes to visualize GPCRs chemical design can solve that antibodies can’t, how to validate functional assay systems, and why fluorescence-based Why peptide-based fluorescent ligands succeeded where antibodies repeatedly failed. at the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin, focusing on developing fluorescent

How academia and biotech collaborate to scale GPCR tools—covering fluorescence assays, GPCR internalization The episode explores gpcr internalization , fluorescence-based probe design, and how functional assay Celtarys Research , a biotech spin-off from the University of Santiago de Compostela focused on advanced fluorescent ligands and GPCR research tools. By combining fluorophore design, ligand chemistry, and pharmacology, his work enables precise visualization

Discover pHSense™ portfolio From binding to signaling to internalization: Cell-based fluorescence assays for complete GPCR characterization The principle of pHSense™ relies on the pH-dependent fluorescence Time-Resolved Fluorescence (TRF) = High Signal-to-Background: Europium’s long-lived fluorescence allows comprehensive reagent portfolio to match that complexity—supporting every stage of the signaling pathway, from ligand Ligand binding Measure receptor engagement with high sensitivity using TR-FRET, radioligand, and Fluorescent

early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar ligand This conversation is especially valuable for scientists developing functional assays, fluorescence-based The moment when femtomolar ligand concentrations uncovered unexpected receptor sensitivity. Why It Might Hit Home If you’ve ever: Faced unexpected assay behavior at ultra-low ligand concentrations

Free GPCR Webinars Fluorescent Probes for GLP-1R and GIPR Imaging: From Cell Assays to In Vivo Systems in vivo systems Choose the right probe for your experimental context Handle, reconstitute, and store fluorescent fellows and graduate researchers entering drug discovery If you work directly with receptor systems, ligand

His current interests include the development of HTS fluorescence-based kinetic binding assays specifically

We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring

With a career spanning two decades at the intersection of fluorescence chemistry, functional assays, Originally trained as a physicist with a strong interest in photophysics and fluorescence chemistry,

He currently uses high-resolution fluorescence microscopy and biochemistry to study GPCR trafficking

“Let’s embrace the challenge to study all of them… they’re unique in how they bind ligands, how selective With hundreds of subtypes and very few known ligands, the structure–function relationships remain largely “The main challenge was: how do we get a face for these proteins when we don’t have ligands?” Build predictive models to discover new ligands . Despite their relevance, they remain understudied due to the limited knowledge of their ligands and the

I Date & Time Thursday, November 2nd / 1:45 PM - 2:45 PM Title: Virion Display to Discover a Novel Ligand My project is investigating a new protein ligand for a GPCR and its potential role in obesity. GPCR Title: Characterization of Novel Opioid-Neurotensin Bifunctional Ligands Designed to Target Pain his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors (GPCRs) ligands

Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the ligand Our first main research aspect is the identification of endogenous ligand of GPCRs. We also identified DHEA, DHEAS and DOC are endogenous ligands of GPR64 etc (Nature, 2021a, Nat Chem Biol Our fourth main research aspect is ligand coding mechanisms and structural aided drug discovery of GPCR

, cannabinoid receptor) and ion channel (K, Ca, TRP channel) function; mostly electrophysiology and fluorescence-based

Our mission is to understand the mechanism and structural bases for ligand binding and efficacy to help This is an important perspective in the pursuit of receptor subtype-specific ligands, a major aspect One example of our recent work surrounds a structure-based effort to develop ligands that specifically Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy We have identified several GPCR ligands that allosterically modulate orthosteric ligand binding and target

Together with Irina Kufareva , UCSD, her team developed a novel approach to identifying ligands for orphan GPCRs by developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed inaccessible receptors to well-characterized and understood ‘unlocked’ therapeutic targets with high-affinity ligands

In addition, I generated various optical biosensors based on fluorescence or bioluminescence resonance

. 🗓️ Upcoming 4-Week Course: Development of GPCR Ligands as Therapeutic Drugs starting March 20 – April Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam Structural and Molecular Insights into GPCR Function A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Ligand-Independent Spontaneous Activation of Purinergic

Lefkowitz , where his research focused on biased agonism, with the development of approaches to quantify ligand The chemokine system is relatively unique in having multiple receptors and multiple ligands that display His group and others have shown that many of these ligands act as biased agonists for the same receptor

exploring the effect of subcellular location on the signaling profile of CXCR3’s three endogenous biased ligands receptor phosphorylation in the differential signaling outputs of biased agonists, and demonstrating the ligand

Why This Matters Computational models are moving beyond interpretation into real-world prediction of ligand-receptor should predict , not just explain How his team uses structure-based modeling to identify novel GPCR ligands His team focuses on understanding how ligands modulate receptor function and how those insights can drive Outside academia, he advises companies through a consulting arm focused on ligand design strategy.

Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is

development of FRET/BRET -based GPCR conformational biosensors, which can be employed in high throughput ligand recently awarded a Marie Sklodowska Curie PostDoc Fellowship in order to investigate and find better ligands

🚀 This workshop will explore how different ligands (compounds) can stabilize unique receptor conformations 🧬 Receptor Flexibility : Ligands stabilize different receptor states, creating unique signaling pathways encourages leveraging bias for better therapeutic outcomes. 📌 Receptors are Dynamic Players 🔹 Different ligands

Angiotensin and Urotensin receptors through various biochemical approaches centered in the elucidation of ligand After a relocation to Stanford University where he pioneered work on ligand discovery for then orphan events in biasing latrophilins’ regulation of cyclic AMP pathways and for determining the magnitude of ligand