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We have a catalogue of over 30 fluorescent ligands for different families of GPCRs, including adenosine Post not marked as liked 4 Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors Celtarys develops fluorescently labeled ligands designed for real-time, non-radioactive GPCR assays—enabling Custom Development Customized fluorescent ligands developed in less than 3 months with optimal properties Product Catalog GPCR Ligands Our GPCR fluorescent ligands are the ideal solution for your High Throughput

At Celtarys, the focus is on enabling fast, customizable development of fluorescent ligands and chemical ligand development. “You can have a great ligand—but if you can’t solubilize it, it’s useless.” — Maria Majellaro Celtarys Their approach is highly consultative—they don’t just sell ligands, they co-develop solutions. GPCR ecosystem , GPCR drug discovery , fluorescent ligands , GPCR scientist network , custom ligand development

protein-coupled receptor kinetics, signaling, and trafficking and on using novel imaging techniques, such as fluorescent ligands and complementation methods, to investigate the underlying mechanisms.

Got hooked on ligand design. Dr. Maria Majellaro didn’t plan to run a biotech company. Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry. 🚀 Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research Known for their fluorescent ligand innovation, Celtarys is helping researchers make biology visible, ligand technologies and real-time, non-radioactive GPCR assays.

Got hooked on ligand design. Dr. Maria Majellaro didn’t plan to run a biotech company. Now she’s leading Celtarys, building custom fluorescent probes, and partnering with Dr. Meet Celtarys and learn more about its leading work on ligand-linker-fluorophore chemistry 🚀 ✳️ Listen

Got hooked on ligand design. Dr. Maria Majellaro didn’t plan to run a biotech company. Now she’s leading Celtarys, building custom fluorescent probes, and partnering with Dr. Meet Celtarys and learn more about its leading work on ligand-linker-fluorophore chemistry 🚀 ✳️ Listen

We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring

His current interests include the development of HTS fluorescence-based kinetic binding assays specifically

He currently uses high-resolution fluorescence microscopy and biochemistry to study GPCR trafficking

, cannabinoid receptor) and ion channel (K, Ca, TRP channel) function; mostly electrophysiology and fluorescence-based

In addition, I generated various optical biosensors based on fluorescence or bioluminescence resonance

“Let’s embrace the challenge to study all of them… they’re unique in how they bind ligands, how selective With hundreds of subtypes and very few known ligands, the structure–function relationships remain largely “The main challenge was: how do we get a face for these proteins when we don’t have ligands?” Build predictive models to discover new ligands . 8. Despite their relevance, they remain understudied due to the limited knowledge of their ligands and the

Together with Irina Kufareva , UCSD, her team developed a novel approach to identifying ligands for orphan GPCRs by developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed inaccessible receptors to well-characterized and understood ‘unlocked’ therapeutic targets with high-affinity ligands

Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the ligand Our first main research aspect is the identification of endogenous ligand of GPCRs. We also identified DHEA, DHEAS and DOC are endogenous ligands of GPR64 etc (Nature, 2021a, Nat Chem Biol Our fourth main research aspect is ligand coding mechanisms and structural aided drug discovery of GPCR

I Date & Time Thursday, November 2nd / 1:45 PM - 2:45 PM Title: Virion Display to Discover a Novel Ligand My project is investigating a new protein ligand for a GPCR and its potential role in obesity. GPCR Title: Characterization of Novel Opioid-Neurotensin Bifunctional Ligands Designed to Target Pain his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors (GPCRs) ligands

Lefkowitz , where his research focused on biased agonism, with the development of approaches to quantify ligand The chemokine system is relatively unique in having multiple receptors and multiple ligands that display His group and others have shown that many of these ligands act as biased agonists for the same receptor

. 🗓️ Upcoming 4-Week Course: Development of GPCR Ligands as Therapeutic Drugs starting March 20 – April Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam Structural and Molecular Insights into GPCR Function A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Ligand-Independent Spontaneous Activation of Purinergic

exploring the effect of subcellular location on the signaling profile of CXCR3’s three endogenous biased ligands receptor phosphorylation in the differential signaling outputs of biased agonists, and demonstrating the ligand

development of FRET/BRET -based GPCR conformational biosensors, which can be employed in high throughput ligand recently awarded a Marie Sklodowska Curie PostDoc Fellowship in order to investigate and find better ligands

Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is

Angiotensin and Urotensin receptors through various biochemical approaches centered in the elucidation of ligand After a relocation to Stanford University where he pioneered work on ligand discovery for then orphan events in biasing latrophilins’ regulation of cyclic AMP pathways and for determining the magnitude of ligand

He is one of the coordinators of recommendations to describe ligand bias towards signaling probes and His group recently developed an online resource of biased ligands and pathway effects to advance the

Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry.

Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry.

Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry.

Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry.

Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry.

Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry.