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built numerous technologies in gene synthesis, DNA information storage, gene editing, and large-scale multiplexed assays.

Badr recounted Badr's Journey, Multiplexing Assays, and Collaboration Badr shared his learning process Yamina emphasized the potential of multiplexing assays in expanding the scope of scientific exploration

Ilana Kotliar built a multiplexed platform to map GPCR-RAMP interactions and uncover autoantibody-driven assay.” – Tom Sakmar After exploring several screening techniques, the lab adopted the Luminex bead-based assay , which allowed simultaneous detection of multiple GPCR-RAMP interactions. assays. focusing on a single receptor, students now gravitate toward platforms , biosensors , and data-rich assays

Assay Principle of Eurofins DiscoverX Cell-based Assays Whether you are developing small-molecule or assay types and applications to meet your specific GPCR research needs. with hundreds of binding and functional assays, available individually or in panels. These assays use the same platform as the Eurofins DiscoverX assays and beyond. These GPCRs are excellent for use in functional, structural, or identification assays.

Explore Martin Marro’s impact on GPCR drug discovery, assay innovation, and translational pharmacology bridging academia, pharma, and biotech. << Back to podcast list Strategic Partner(s) GPCR Assay Strategy Marro’s career spans big pharma and biotech, encompassing functional assay development, GPCR internalization The conversation explores the realities of using fluorescence-based assays, the challenge of translating How advanced assay design is essential for translating cell-based GPCR signals to therapeutic outcomes

Trinquet discusses the science and story behind pH Sense, Revvity’s innovative GPCR internalization assay product R&D. << Back to podcast list Strategic Partner(s) From Rare Earth Probes to Internalization Assays Eric Trinquet What does it take to design a breakthrough GPCR assay—from idea to industrial impact? With a career spanning two decades at the intersection of fluorescence chemistry, functional assays, What shifted the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights This conversation is especially valuable for scientists developing functional assays, fluorescence-based What early cyclic AMP assays revealed about spatial signaling long before high-content technologies existed Why It Might Hit Home If you’ve ever: Faced unexpected assay behavior at ultra-low ligand concentrations Get behind-the-scenes conversations, advanced assay development strategies, and practical GPCR tools

Accelerated Program Progression: Design robust assay cascades and establish key go/no-go points to speed Accelerated Preclinical Progression I streamline critical operational processes, from advanced assay Small missteps can derail entire programs: underperforming assays, off-track CROs, and data that fails Before working with Yamina, we had solid internal momentum but needed to better align our biology, assay structure the screening funnel, define clear go/no-go criteria, and integrate ADME and mechanistic assays

Discover pHSense™ portfolio From binding to signaling to internalization: Cell-based fluorescence assays This results in high sensitivity and specificity in no-wash, plate-based live-cell assays. pHSense™ Eu G-Protein Activation Quantify Gs, Gi, and Gq activation in real time with cAMP, GTP, and IP-One assays Arrestin Recruitment Detect β-arrestin recruitment with TR-FRET and luminescence assays tailored for Build Your GPCR Assay Workflow Meet the Team behind pHSense™ Eric TRINQUET Sr Director Life Sciences

He also discussed the evolution of the field, from biochemical radioligand binding assays to cell-based functional assays, and the influence of Terry Kenakin and chemical programs on his later work. They discussed strategies for analyzing large compound screening data, emphasizing robust assays and Arthur recounted a 2004 visit to a pharma company using replicates in assays. conversation highlighted the importance of establishing the correct disease context, setting up appropriate assays

I then undertook my first project where I demonstrated that MRAP2 regulates the signaling of multiple MRAP2 regulates GHSR1a signaling; this project brought forth our NanoBiT-based arrestin recruitment assay This powerful tool allowed us to create an assay that kinetically measured the arrestin recruitment to I joined the lab, I became proficient in many In-vivo techniques, I adapted my arrestin recruitment assay

Johannes Broichhagen reveals how fluorescent probes transform GPCR imaging, internalization studies, and assay He explains what chemical design can solve that antibodies can’t, how to validate functional assay systems , and why fluorescence-based assays paired with careful synthetic planning open doors for both high-resolution How parallel synthesis and side-by-side functional assays accelerate probe optimization and reduce false Tried to build assays that behave in living cells—not just on paper.

< Back to Webinars Fluorescent Probes for GLP-1R and GIPR Imaging: From Cell Assays to In Vivo Systems Available across multiple spectral ranges for confocal, super-resolution, and intravital imaging. daLUXendin Broad GPCR fluorescent ligand portfolio across multiple receptor families Fluorescence Polarization,

During my PhD, I learnt radioligand binding assays, behavioral assays, autoradiography, stereotaxic surgeries

INSERM with a specific interest in G protein-coupled receptors by developing original BRET and TR-FRET assays He discovered multiple rare and loss-of-function variants of the MT2 melatonin receptors that are associated

Discover how Celtarys Research is transforming GPCR assay development with fluorescent ligands in this focus is on enabling fast, customizable development of fluorescent ligands and chemical probes for GPCR assays GPCR, Celtarys will bring those lessons to the broader community, providing insight into assay development Each probe must retain activity, remain soluble, and be compatible with a given assay format. Whether you're designing assays, developing probes, or seeking better tools for GPCR drug discovery,

How academia and biotech collaborate to scale GPCR tools—covering fluorescence assays, GPCR internalization The episode explores gpcr internalization , fluorescence-based probe design, and how functional assay tools lose impact when distribution and access aren’t planned from the start Why fluorescence-based assays from academic tool development to real-world adoption Balancing innovation with validation in GPCR assay Her work centers on GPCR modulators, synthetic chemistry, and enabling robust biological assays through

David has over 20+ years of experience working in a drug discovery environment mainly in a specialist assay His current interests include the development of HTS fluorescence-based kinetic binding assays specifically

taste receptors in cancer and metabolic diseases, and emerging high-throughput methods for functional assay generation How computational approaches and wet-lab validation complement each other in functional assay localization and need to understand the mechanistic role of microdomains If you’re expanding functional assays

the Forefront of GPCR Drug Discovery Gain insider methods from the pioneers shaping biased signaling, assay Terry Kenakin Decoding Drug Action <p class="font_8">Watch Now</p> Terry Kenakin Seeing is Believing: Assaying Pharmechanics GPCR signaling & biased agonism expert regularly consulted by top pharma companies for assay A deep-dive training session led by top GPCR scientists, covering pharmacology, signaling, assays, and

Khorana’s lab made early key contributions and developed strategies to express, reconstitute and assay He also went on to discover a “counterion switch” in visual pigments and to develop strategies to assay Howard Hughes Medical Institute appointment, Tom advanced a series of novel biochemical and biophysical assay

His focus is on expanding commercial reach and accelerating the adoption of the company’s GPCR assay fluorescently labeled ligands and innovative chemical biology tools to support real-time, non-radioactive GPCR assays GPCR Functional Assay Fluorescent GTPγS enables sensitive, non-radioactive GPCR activity assays for drug

Prioritize assays based on project phase and decision points Map go/no-go logic that guides program momentum they’ll change outcomes No More Strategy Swirl I build structure that sticks—from CRO engagement to assay

engagement in intact islets and neuronal circuits — insights that inform next-generation functional assay on biological context Balanced innovation with the need for reproducible, well-controlled functional assays

clear expectations and deliverables to build trust and reduce delays • Align teams across roles—from assay Decisions—Not Delays I help turn great science into clear deliverables • Define program objectives and guide assay

His current work is mainly focused on screening and assay development to bridge the gap between in vitro

the human aGPCRs CD97/ADGRE5 and Latrophilin/ADGRL3 and tested in HEK293T cells using a luciferase assay Tobias Langenhan's group, where I currently manage a project to establish a drug screening assay for In addition, the platform was used to develop assays for high-throughput screening for challenging adhesion

There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity

Free GPCR Webinars Fluorescent Probes for GLP-1R and GIPR Imaging: From Cell Assays to In Vivo Systems Allosteric modulators (PAMs and NAMs) • Biased agonism • Dose–response modeling • Calcium and signaling assays

Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor binding assay