Alex Serafini shares why pain research must start with real-world behavior and models before drilling pain research at Hopkins and later an MD-PhD at Mount Sinai. He points out that GPCRs—especially orphan and CNS-associated ones—are often downplayed in pain research That changed everything.” — Alex Serafini Pivoting: Redefining the Pain Research Playbook Looking ahead That top-down approach, though less common, could help pain research finally catch up with the complexity

At the end of 2023, I joined the research group of Dr. Nigel Bunnett at the NYU Pain Research Center as a postdoctoral researcher. and chronic pain. Next Steps Badr will continue focusing his research on GPCRs involved in pain and inflammation during , and how his PhD research on non-canonical GPCR roles laid the foundation for his postdoc work.

GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors relevant for treating osteoporosis, diabetes, and pain. As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and passion, I recently started a postdoctoral fellowship to study the role of GPCRs in the mechanisms of pain GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the Yamina Berchiche on the web Website LinkedIn Facebook Twitter ResearchGate PubMed Google Scholar Dr.

allosteric opioid modulators, receptor internalization, and navigating the transition from academic GPCR research Livingston's PhD research at the University of Michigan addressed this systematically - mapping selectivity and analytical instrumentation - to Product Manager, translating customer research needs into commercial a career model for GPCR-trained scientists The structural complementarity of academic and industry research Research into their mechanism of action in purified systems formed the base of her thesis work.

Pradhan returns to often: that organisms in chronic pain are fundamentally different biological systems been her scientific focus for nearly two decades, through failed clinical trials in depression and pain Her research integrates behavioral pharmacology, ligand-directed signaling, and mouse models of migraine After failed trials in depression and pain, Dr. Amynah did her undergrad research measuring IP3 in airway smooth muscle cells and completed a Ph.D. at

Biotech founder Ajay Yekkirala shares how AI, GPCRs, and bold questions are driving next-gen pain therapeutics Learn in This Episode How Ajay’s failed MD/PhD application rerouted his path toward a breakthrough GPCR research career The inside story behind founding Blue Therapeutics and targeting supraspinal pain pathway What Woolf at Boston Children’s Hospital and Harvard Medical School, where he deepened his understanding of pain , a biotech startup focused on targeting supraspinal GPCRs for chronic pain.

for biology and a childhood dream of being an astronaut, he began with intestinal choline transport research “We’re enhancing the powerful pain-relieving effects of opioids while limiting respiratory depression He is particularly excited by the novel application of PAMs in chronic and neuropathic pain models , Discovering breakthrough results in neuroma pain models via a spontaneous collaboration. Advice for Junior Scientists: Read, Rest, Run Ben closes with wisdom for early-career researchers: “Academia

Laura Bohn at Scripps Research Institute. recurring example: the same molecule promotes opioid antinociception in one context, drives chronic pain the dorsal horn lights up with phospho-ERK in response to opioid, routing through RSK1/2 to stronger pain With a non-selective HSP90 inhibitor given systemically, the brain effect dominates and pain relief is Laura Bohn’s lab at Scripps Research Institute in Florida.

Grant-funded independent research positions from 2001 at University of Sydney (opioids and sensory neurons ), Vollum Institute Portland (visiting scientist with Ed McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids, cannabinoids and T-type Ca channels) and Brain and Mind Research Institute (Sydney). 2009, appointed Professor of Pharmacology at Macquarie University. Mark Connor on the web Researchers Twitter Google Scholar Dr. GPCR Ecosystem Unlock the Full Dr.

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors relevant for treating osteoporosis, diabetes, and pain. Shivani Sachdev on the web NIDDK ReseachGate Google Scholar LinkedIn Twitter Dr.

Graciela Piñeyro — who leads an opioid receptor pharmacology group at the CHU Sainte-Justine Research Graciela Piñeyro is a principal investigator at the CHU Sainte-Justine Research Center and a professor Trained as a physician in Uruguay, she began doing research in the only way then available to her — through This interest in research and pharmacology took Graciela to Canada where she stayed ever since she arrived Graciela Pineyro - CHU Ste-Justine Research Centre Pineyro Lab Publications on Google Scholar Pineyro

Catherine Demery shares how she found clarity and purpose in academic opioid research. building translational experiments, and using real-world data to drive impactful science in the GPCR research Her research combines cutting-edge GPCR signaling studies with real-time public health data from Michigan The role of public health programs in informing lab research. But loss has a way of sharpening focus—friends lost to overdose brought the opioid epidemic into painful

the Johns Hopkins University Medical Center, where he received an NIH Bench to Bedside Translational Research topological data analysis to build GPCR based therapeutics that act on the gerontological roots of disease, a research A receptor system cannot hold its shape for eighty years When he moved into aging research, one question He calls the reinvention painful and brutal, and does it anyway. user=KQ6pwbEAAAAJ&hl=en&oi=ao ResearchGate: https://www.researchgate.net/profile/Stuart-Maudsley Maudsley

prestigious Clinician Postdoctoral Fellowships offered by Alberta Innovates and Canadian Institutes of Health Research In her time as an undergraduate, Maddi was a researcher in Dr. Klein's lab where she helped to investigate the role of various ATP-sensitive potassium channels in pain From there, she went on to be a research technologist in Dr.

Hay, who has studied RAMPs since they were first described and when working on them was a high-risk research Her research centers on the molecular pharmacology of class B GPCRs - specifically the calcitonin receptor She has worked across pharmaceutical, biotechnology, and academic settings, including a research placement For a condition affecting up to 20% of women worldwide, Hay notes, the research investment in understanding Hay on the web LinkedIn Wikipedia University of Otago University of Auckland Google Scholar Pubmed Research

shares what a forced lab shutdown taught her about prioritization, remote lab meetings, and running a research Back to podcast list Strategic Partner(s) Graciela Pineyro: Resilience, Lab Life, and the Zoom Effect Research Civic responsibility in returning to the bench — Deconfining a research center slowly, with planning The research center was deconfining at 20% capacity the week of the recording. Dr. of opioid receptors and is currently focusing on the pharmacology of cannabinoids in the context of pain

His research focuses on novel paradigms of drug action at GPCRs, particularly allosteric modulation and Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology Next steps - Arthur will continue to collaborate with other researchers and drug companies to advance The conversation ended with Arthur's ongoing research and his development of a new operational model.

His research focuses on novel paradigms of drug action at GPCRs, particularly allosteric modulation and encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes, chronic pain Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & GPCR researchers in Australia and the initiation of a successful series of conferences. and its capacity to translate research into therapeutic commercialization.

His research focuses on novel paradigms of drug action at GPCRs, particularly allosteric modulation and encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes, chronic pain Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & GPCR researchers in Australia and the initiation of a successful series of conferences. and its capacity to translate research into therapeutic commercialization.

<< Back to podcast list Strategic Partner(s) Exploring Career Paths in GPCR Research with Dr. After completing his Ph.D., he pursued research in genetics of metabolic regulation at the Institute of Metabolic Science - Metabolic Research Laboratories at the University of Cambridge in the team led of method development, integrity, and honesty in scientific research. their research interests and achievements, particularly in the field of GPCR.

During his last year of studies, Timo performed research in the biopharmaceutical company Argen X and Raimond Heukers , developed a nanobody platform within the research group and used this platform to develop During his Ph.D., he used these nanobodies as research tools, to investigate different GPCR conformations Starting from September 2019, Timo started working as a postdoctoral researcher at the Vrije Universiteit future, Timo hopes to combine his previous GPCR experience with his current focus to set up his own research

Graeme Milligan Professor Graeme Milligan is Gardiner Professor of Biochemistry, Dean of Research, and His main research group centers on the function, structure, and regulation of G protein-coupled receptors Milligan has published more than 550 peer-reviewed articles and his research has been cited more than Graeme Milligan on the web University of Glasgow ResearchGate PubMed Orcid Google Scholar LinkedIn Dr

University in Paris and a short internship at Genentech Inc. in South San Francisco, he joined the CNRS as a Research Since 2008, he has arrived at McGill University as a Canada Research Chair. At McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to trainees obtain positions in the academic or private sectors or are currently pursuing postdoctoral research Bruno Giros on the web Dougles Research Center LinkedIn Google Scholar Researchgate Dr.

Her background spans high-throughput, molecular, and systems biology research, which lets her speak to The easy readout drifts away from the biology researchers actually want to measure. The guests frame their work as talking to peers who understand the same pains, not selling a catalog.

Beaulieu was an associate professor and Canada Research Chair (Tier2) in the Department of Psychiatry Beaulieu’s research is aimed at understanding how cellular and molecular mechanisms regulated by psychoactive Translational validation is important to validate findings obtained from experimental models research In addition to basic research, the Beaulieu group is also actively implicated in translational research Jean Martin Beaulieu on the web University of Toronto Google Scholar LinkedIn ResearchGate Dr.

at Cold Spring Harbor Laboratory and probed the roles of polarity proteins (Feigin, et al., Cancer Research Quick recap Yamina and Mike engaged in a conversation about their scientific research experiences. Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its The conversation ended with Yamina expressing interest in learning more about Mike's two main research Cytokine Inhibition, Collaboration, and Anti-Anxiety Drug Research Mike discussed the ongoing research

GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the Yamina Berchiche on the web Website LinkedIn Facebook Twitter ResearchGate PubMed Google Scholar Dr. My experience in basic research at several universities worldwide and early R&D at Novo Nordisk A/S allowed Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control Trejo’s research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation

Structural biologist Qing Fan describes a decade of GABA-B receptor research at Columbia - from obligate A structural biologist by training, her research focuses on the three-dimensional architecture of class - with particular emphasis on the GABA-B receptor, which she has studied as her primary independent research That arc is the product of a community of researchers willing to stay with one system long enough to Fan at Columbia University Research Gate LinkedIn Pubmed Dr. GPCR Ecosystem Unlock the Full Dr.

Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control Trejo’s research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation San Diego Trejo Lab Wikipedia LinkedIn Google Scholar Orcid Twitter UC San Diego School of Medicine Researchgate