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John Azietaku on the web LinkedIn Dr. GPCR About Ya-Tzu Li Ya-Tzu is a Master's student at the University of South Florida, utilizing large-scale In August, Ya-Tzu will continue her academic and research pursuits by beginning her PhD training in Medical Ya-Tzu Li on the web LinkedIn Dr. Cam Sinh Lu on the web LinkedIn Dr.

<< Back to podcast list Strategic Partner(s) Dr. Nicolas Gilles About Dr. Nicolas Gilles "Dr. His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization Nicolas Gilles on the web Google Scholar LinkedIn Dr. GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

<< Back to podcast list Strategic Partner(s) Dr. Robert J. His legacy lies in the numerous discoveries he and his team made in the GPCR field and in all those who GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit

. << Back to podcast list Strategic Partner(s) From Rare Earth Probes to Internalization Assays: The the IP-One kit, Tag-lite, and now, pH Sense. HTRF, the IP-One kit, and the Tag-lite platform into widespread use. His passion lies in turning cutting-edge probe chemistry into robust, scalable tools for drug discovery GPCR X Revvity Collaboration Want more like this? Join the Dr.

. << Back to podcast list Strategic Partner(s) From Curiosity to Breakthrough: Ajay Yekkirala on GPCR Innovation What if the key to safer, more effective drugs lies in asking the right questions — and daring Seeing the limits of traditional drug discovery, he later co-founded Superluminal Medicines, a company Ajay Yekkirala on the web Superluminal Medicines LinkedIn Tune in now to hear how asking “what if?” Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

Email us if you'd like to teach or if you'd like to learn more about any particular topic. 🗓️ Upcoming 4-Week Course: Development of GPCR Ligands as Therapeutic Drugs starting March 20 – April 10, 2025 ( Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C Qin Wang , Wenwen Hao , Jing Li

. << Back to podcast list Strategic Partner(s) Dr. The answer lies somewhere in the diversity of receptor architectures — long C-termini versus long ICL3s What a one-line email to Bob Lefkowitz can do Toward the end of his PhD in Frankfurt, Dr. That is where I realized research is what I want to do for the rest of my life." Arun Shukla Lab Google Scholar PubMed Wikipedia LinkedIn Twitter Dr.

Live scientific exchanges with leading GPCR experts. GPCR University Try it for 14 days Upcoming live sessions Your next Live Masterclass Session is waiting Every session recorded Can't make it live? Are the sessions live or recorded? Masterclass sessions are conducted live with an invited expert. See what it feels like for 14 days.

The discussion covers why degenerate oligos had been the bottleneck for library quality, how a "library of libraries" strategy sidesteps the ten-billion-variant ceiling that caps any single phage library, library of libraries as an answer to the diversity ceiling of single phage libraries Greenfield target his library of libraries. One way around that limited diversity is to actually have multiple libraries."

Graciela Piñeyro on what happened when her lab tested biased agonism at the μ-opioid receptor across 25 ligands Graciela Piñeyro: Partial Agonism, Receptor Recycling, and the Limits of Bias For over a decade, biased Across 25 ligands profiled at the μ-opioid receptor, the team found no bias, only partial agonism. from Pfizer — they could not identify a ligand-bias signature. Graciela Pineyro on LinkedIn Dr. Graciela Pineyro - University of Montreal Dr.

. << Back to podcast list Strategic Partner(s) Dr. Graciela Pineyro: Resilience, Lab Life, and the Zoom Effect Research doesn't pause neatly. GPCR Podcast series capturing the realities of scientific life, returns to Dr. She does not separate this from the scientific conversation — and the listener shouldn't either. Graciela Pineyro on LinkedIn Dr. Graciela Pineyro - University of Montreal Dr.

Maria Waldhoer on why endpoint GPCR assays miss most of what ligands do — and what kinetic pharmacological fingerprints reveal instead. << Back to podcast list Strategic Partner(s) Dr. Maria Waldhoer: Pharmacological Fingerprints and the Limits of Bias Dr. "What endogenous level would you like me to mimic?" Maria Waldhoer on the web LinkedIn InterAx Biotech Pubmed Dr.

<< Back to podcast list Strategic Partner(s) Dr. Simone Prömel & Dr. Ines Liebscher About Dr. Together with Ines Liebscher, Simone is leading an EU-funded COST Network on Adhesion GPCRs: CA18240 Ines Liebscher Dr. With the little knowledge on these receptors available, there were multiple questions to tackle. Ines Liebscher on the web Website LinkedIn Researchgate Dr.

. << Back to podcast list Strategic Partner(s) Finance is Science too: How Numbers Keep the Lights On Both Chuck and Joe agree: accounting is like solving puzzles. It's about structure, order, and breakthrough moments , not unlike the life of a researcher. They avoid companies that don’t align with their values, like the vaping industry. Company Launch Partners on the web Company Launch Partners Upcoming Live Expert Sessions ➚ 🔒Explore

. << Back to podcast list Strategic Partner(s) Dr. Understanding how ligand binding leads to specific signaling outcomes—particularly ligand bias toward can reproduce experimentally measured ligand bias. Episode Timeline 00:00 — Introduction: From ligand binding to receptor signaling Overview of ligand bias It combined both things I liked.

<< Back to podcast list Strategic Partner(s) Dr. Kathryn E Livingston About Dr. Kathryn E Livingston Dr. Kathryn E Livingston is currently a Product Manager at Gator Bio , a biotechnology company providing Kathryn E Livingston on the web LinkedIn ResearchGate Pubmed Google Scholar Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

Explore GPCR lipid rafts, bitter taste receptor pharmacology, and data integration in this expert interview Keyvan Sedaghat. << Back to podcast list Strategic Partner(s) How Lipid Rafts Organize GPCR Signaling Keyvan Sedaghat discussing how GPCR function is shaped by lipid raft compartmentalization, the expanding Sedaghat details the construction of an open-access GPCR-lipid raft database and reviews key findings Guest on the Web LinkedIn 7TMR-RAFT database Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass

Discover how Celtarys Research is transforming GPCR assay development with fluorescent ligands in this GPCR means for the global research community. << Back to podcast list Strategic Partner(s) Custom Molecules , Fluorescent Probes: When Chemists Think Like Biologists with Dr. Their approach is highly consultative—they don’t just sell ligands, they co-develop solutions. Maria Majellaro on the web LinkedIn ResearchGate Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass

. << Back to podcast list Strategic Partner(s) Smells Like GPCR Spirit: Cracking Olfactory Codes with Like many, his path to GPCR research wasn’t linear—it evolved through academic exploration and mentorship Build predictive models to discover new ligands . Explore online resources like “Talktorials.” Despite their relevance, they remain understudied due to the limited knowledge of their ligands and the

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are saying about this podcast "You made it a very comfortable and engaging experience, and it felt like I've listened to the episodes multiple times and it's just like being at a conference getting new ideas Am very grateful for Dr GPCR livening up the week in these difficult times! Sam @Pharmamechanic Listen and subscribe where you get your podcasts

. << Back to podcast list Strategic Partner(s) Dr. When I was about ten years old, I lived on an island in the Stockholm archipelago. Yamina Berchiche: So your father pushed you into science quite literally. Dr. This has been observed in athletes and even in livestock production. Different ligands can bias signaling toward different pathways.

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Live Masterclass Live scientific exchanges with leading GPCR experts. Explore Live Masterclass → Job Listings GPCR-specific job opportunities curated for the community. Live Masterclass In the room with the scientist, not watching from the audience Live scientific exchanges Are the masterclasses on-demand or live? Dr. See what it feels like Already know this is home?

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. << Back to podcast list Strategic Partner(s) Dr. Pluznick ran as a postdoctoral fellow placed them, surprisingly, at the top of a kidney gene expression list not as smell receptors but as general-purpose chemosensors — scattered across the body and tuned to ligands Pluznick's postdoc screen flagged olfactory receptors as top hits in a kidney disease cell line, her And somehow when he said it, it sounded like a much better idea."

. << Back to podcast list Strategic Partner(s) Dr. It also confronts where the field still struggles — translating biased agonism from cell line to clinic The Ligand That Wasn't the Ligand Screening orphan receptors in yeast, the team chased peptide hits that So it turned out that the ligands were not the peptides at all." Fiona Marshall on the web LinkedIn Twitter Google Scholar MSD UK Dr.

<< Back to podcast list Strategic Partner(s) EARNEST Panel: Can AI Accelerate GPCR Drug Discovery? Random-forest classifiers trained on known peptide ligands can find new orphan-receptor pairings. The panel agreed that the real limits are the availability of high-resolution GPCR structures and the And I'm like, that's rubbish. Never picked it up. Complete rubbish. Yamina Berchiche on the web Website LinkedIn Publications Twitter Facebook Dr.

. << Back to podcast list Strategic Partner(s) Dr. The chemokine system — roughly 50 ligands for 20 receptors — was framed for decades as redundant because That's the kind of story that I like to share in the podcast." GPCR Ecosystem Member Website LinkedIn Publications Twitter Facebook Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr.

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