📰 GPCR Weekly News, July 10 to 16, 2023

Welcome, GPCR enthusiasts! This week's GPCR papers feature a publication by Dr. Robert J Lefkowitz.

Join us tomorrow, July 21, in the Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation! The symposium will feature a trainee day with a career panel. Remember to subscribe to Dr. GPCR Newsletter for updates!

Check the weekly Classified GPCR News from July 10th to July 16th, 2023.

GPCR Activation and Signaling

• Bias comes in layers.

GPCR Binders, Drugs, and more

• Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models.

GPCRs in Cardiology, Endocrinology, and Taste

• Clinical, Pathophysiologic, Genetic, and Therapeutic Progress in Primary Bilateral Macronodular Adrenal Hyperplasia.

GPCRs in Neuroscience

• The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. elegans.

GPCRs in Oncology and Immunology

• Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice.

• Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling.

• Colorectal cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004-2018.

Methods & Updates in GPCR Research

• Evaluation of Drug Responses to Human β2AR Using Native Mass Spectrometry.

• psnGPCRdb: The Structure-network Database of G Protein Coupled Receptors.

Reviews, GPCRs, and more

• Optical approaches for investigating neuromodulation and G Protein-Coupled Receptor signaling.

• Hijacking of GPCRs and RTKs by pathogens.

Structural and Molecular Insights into GPCR Function

• ALX/FPR2 Activation by Stereoisomers of D1 Resolvins Elucidating with Molecular Dynamics Simulation.

• The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs.

• Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase.

Industry News

• Septerna Secures $150 Million in Series B Financing to Advance Pipeline of Novel GPCR-targeted Medicines

• OMass Therapeutics was shortlisted for ‘Life Sciences and Health Tech Company of the Year’ in the 2023 Thames Valley Tech Awards

• Sosei Heptares Webinar Presentation for Q2 FY2023 Financial Results

• Neurocrine Biosciences Announces Appointment of Christine A. Poon to Board of Directors

• Crinetics Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

• Confo Therapeutics CEO, Cedric Ververken, will join WuXi AppTec's upcoming online series "BOLD: Innovation That Matters"

GPCR Events, Meetings, and Webinars

• ONCORNET2.0 Final Symposium (August 31 - September 1, 2023) Registration ends Tomorrow!

• NEW Discovery On Target (September 25 - 28, 2023)

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023) Registration is now open!

• NEW MPGPCR Conference (November 15 -17, 2023)

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• NEW Senior Research Specialist - Natural Sciences - Surgery

• NEW Senior Scientist- Membrane Technologies

• NEW Computational Protein Design (GPCR)

• Postdoctoral Fellow, Caron Lab

• Clinical Trial Associate

• Research Scientist/Senior Scientist I - Molecular Pharmacology

Explore Dr. GPCR Ecosystem