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These dimeric interactions may contribute to the phenomenon of biased agonism, where ligands produce ) has revealed that GLP-1R homodimerization occurs via transmembrane helix 4 (TM4), which forms the interface Guo, W., et al., Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface

inhibit Ca2+ entry, or directly at SNARE complexes to inhibit Ca2+-dependent synaptotagmin-SNARE complex interactions

Structural Understanding of Peptide-Bound G Protein-Coupled Receptors: Peptide-Target Interactions. SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023). 2nd ERNEST Training School

ARRB1 interacted with HBx, and the autophagic core protein MAP1LC3/LC3, a scaffolding protein, was essential

with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function Interaction Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Research Technologist I Senior Scientist- Internal

GPCRs in Neuroscience GPCR interactions involving metabotropic glutamate receptors and their relevance

progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours Rhodopsin orphan GPCR20 interacts Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International

-17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions

, 2023) NEW ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions

protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions Conference November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting February 3 - 7, 2024 | SLAS2024 International

basis of μ-opioid receptor targeting by a nanobody antagonist Probing the energy landscape of the lipid interactions

Report of the 4th international symposium. GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS

and Signaling Unraveling the crosstalk between renin-angiotensin system receptors Arrestin-centred interactions Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Associate Research Technologist I Senior Scientist- Internal

-17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions

Internal and external modulation factors of the orexin system (REVIEW). Multi-omics integration analysis of GPCRs in pan-cancer to uncover inter-omics relationships and potential Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24

Immunology Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions February 1 | GPCR Forum ECI February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition February

the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization Insights into GPCR Function Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International

GPCR Activation and Signaling GPCR-dependent and -independent arrestin signaling Direct GPCR-EGFR interaction

ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions

Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis

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signaling Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction

Therefore, the study of the different signal transductions triggered by the opioid-receptor interaction The authors found that both β-arrestin 1 and 2 are involved in MOR internalization and downstream signaling

Structural studies at high resolution have illuminated the intricate interactions between NTSR1 and GRK2

bioluminescence resonance energy transfer Bayesian network models identify cooperative GPCR:G protein interactions

In the endosomes, sustained G protein signaling has been associated with prolonged interactions between Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles. Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

When he moved to Uppsala in the late 1990s to study engineering, it was biotechnology—then on the rise—that

superior choice for GPCR calcium signalling GPCR: Structural Insights and Role in Drug Discovery Orion Biotechnology has a new website GPCR Events, Meetings, and Webinars November 25 - 26, 2024 | 6th International Conference Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International

receptor 3 Industry News New cannabinoid CB1 receptor antagonists disclosed in Inversago patent Orion Biotechnology

Clinical Study to Further Evaluate Functional Precision Medicine Platform in Cancer Patients Orion Biotechnology