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We designed an integrative approach to improve comparative modeling of TAS2Rs. We constructed accurate homology models of human TAS2Rs. As a test case, we examined the accuracy of the TAS2R16 model with site-directed mutagenesis and in vitro

Methods: Using a widely adopted rodent model of 3-day recurrent hypoglycemia, we first checked expression The abovementioned studies were repeated in streptozotocin-induced diabetic rat model.

These results provide new insights on the role of the extracellular domain in differentially modulating

As the lab grew, so did his responsibilities: from building computational models of GPCRs to guiding

They believe their data package is strong, their models are validated, and they’re ready to move forward 4️⃣ Comparative value: Have you positioned your therapeutic against the right standard or competitor,

August 2022 "Abstract Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related This introduces an element of uncertainty in the accuracy of rodent models for performing such preclinical

Study known & orphan GPCRs Identify new accessory protein interactions Build disease-relevant signaling models

Whit this scope, the authors challenged the current model, wich suggest that β-arrestin translocates Based on all the information collected, the authors proposed the following multistep model for receptor-β-arrestin Although this study has limitations, such as the absence of the flexible distal C-tail of βArr2 in the model used, its findings redefine the existing model of receptor-β-arrestin interactions.

Modulating GPCR and 14-3-3 protein interactions: prospects for CNS drug discovery.

coupled receptors (MRGPRs), a subfamily of GPCRs, are largely expressed by sensory neurons and known to modulate

imaging — it was proof that receptors could be seen as they truly exist in native tissue, not simplified models The Collaboration Model That Makes GPCR Imaging Possible Behind every technical advance in this story

Margarita Stampelou, Graham Ladds, and Antonios Kolocouris refine AlphaFold models using binding calculations Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Post-Doc position Lead Researcher Senior Researcher in Structural Biology Post-Doctoral Fellow Postdoctoral Fellow

There, Ajay expanded his understanding of neurobiology and translational research models, further refining The company’s goal is to model receptor dynamics — including biased signaling — to predict drug behavior

Sometimes you’re working with linear fits: Schild plots, dose ratios, regression models. insights  distilled from decades of pharmacology experience Whether you’re validating assays, refining models

Your Access To Terry's Corner ➤ Why the Myth of Multiple Affinity Sites Slows You Down Traditional models both pharma and startup environments Read Maria Majellaro's Full Recap ➤ Lab Leadership Without Ego: A Model

who can map GPCR signaling with precision and design therapies that fit real biology — not idealized models problems — the kind that require chemistry, physiology, pharmacology, structural biology, computational modeling

of the most recent findings in human studies and contextualize them considering previous preclinical models

Xenograft mouse model was generated to investigate the in vivo efficacy of fentanyl.

Watch Episode 174 You never forget the day your data surprises you—in a positive way. For Dr. Platform — Not a One-Off Assay The brilliance of pHSense lies not only in the chemistry but also in its modularity

high-resolution techniques to investigate peptidergic transmission and expression throughout the brain in model Neuropeptides exhibit distinct characteristics which includes their post-translational processing, release

July 2022 "I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics

& Updates in GPCR Research A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation

Dose prediction models need kinetic nuance—not just Cmax and AUC. You can’t model irreversible binding with the usual tools.

subcellular localization and activity in a polarized epithelium using the Drosophila wing imaginal disc as a model

Our model not only shows the function of dimeric β2-AR but also provides a molecular insight into the

a clearly defined biological question and the careful selection of a physiologically relevant cell model Layout and Sample Handling Automated liquid handlers and randomized plate layouts are used to minimize positional

tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

CXCR1/2 inhibitors show beneficial effects in various animal models of CVD.

Our model not only shows the function of dimeric β2-AR but also provides a molecular insight into the