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This study examined the therapeutic effect of Ang-(1-7) on secondary injury observed in a murine model of mild TBI (mTBI) in a closed skull, single injury model."

stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model GPCR Jobs Postdoctoral Fellow - Molecular Dynamics Postdoc in lipid regulation of GPCRs Postdoctoral positions

peculiar, and each neuron expresses a single OR gene however, ectopic ORs expression is unlikely to be modulated Due to the diversity of the OR family it will be critical to select potential targets to modulate in

as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate

a recent study , we contributed to the development of a robust HTRF assay for the discovery of new modulators

Opening Ceremony of Xuzhou Zhongshu Research Site and CNS Drug Innovation Forum Nxera Pharma Notes Positive Clinical Pharmacology GPCR Jobs NEW Research Associate Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Become a Premium Member!

most likely due to the fact that these receptors are also expressed by pancreatic islets where they modulate

We designed an integrative approach to improve comparative modeling of TAS2Rs. We constructed accurate homology models of human TAS2Rs. As a test case, we examined the accuracy of the TAS2R16 model with site-directed mutagenesis and in vitro

As the lab grew, so did his responsibilities: from building computational models of GPCRs to guiding

Methods: Using a widely adopted rodent model of 3-day recurrent hypoglycemia, we first checked expression The abovementioned studies were repeated in streptozotocin-induced diabetic rat model.

These results provide new insights on the role of the extracellular domain in differentially modulating

They believe their data package is strong, their models are validated, and they’re ready to move forward 4️⃣ Comparative value: Have you positioned your therapeutic against the right standard or competitor,

Study known & orphan GPCRs Identify new accessory protein interactions Build disease-relevant signaling models

August 2022 "Abstract Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related This introduces an element of uncertainty in the accuracy of rodent models for performing such preclinical

Whit this scope, the authors challenged the current model, wich suggest that β-arrestin translocates Based on all the information collected, the authors proposed the following multistep model for receptor-β-arrestin Although this study has limitations, such as the absence of the flexible distal C-tail of βArr2 in the model used, its findings redefine the existing model of receptor-β-arrestin interactions.

Modulating GPCR and 14-3-3 protein interactions: prospects for CNS drug discovery.

coupled receptors (MRGPRs), a subfamily of GPCRs, are largely expressed by sensory neurons and known to modulate

imaging — it was proof that receptors could be seen as they truly exist in native tissue, not simplified models The Collaboration Model That Makes GPCR Imaging Possible Behind every technical advance in this story

Margarita Stampelou, Graham Ladds, and Antonios Kolocouris refine AlphaFold models using binding calculations Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Post-Doc position Lead Researcher Senior Researcher in Structural Biology Post-Doctoral Fellow Postdoctoral Fellow

There, Ajay expanded his understanding of neurobiology and translational research models, further refining The company’s goal is to model receptor dynamics — including biased signaling — to predict drug behavior

Sometimes you’re working with linear fits: Schild plots, dose ratios, regression models. insights  distilled from decades of pharmacology experience Whether you’re validating assays, refining models

Your Access To Terry's Corner ➤ Why the Myth of Multiple Affinity Sites Slows You Down Traditional models both pharma and startup environments Read Maria Majellaro's Full Recap ➤ Lab Leadership Without Ego: A Model

who can map GPCR signaling with precision and design therapies that fit real biology — not idealized models problems — the kind that require chemistry, physiology, pharmacology, structural biology, computational modeling

Watch Episode 174 You never forget the day your data surprises you—in a positive way. For Dr. Platform — Not a One-Off Assay The brilliance of pHSense lies not only in the chemistry but also in its modularity

of the most recent findings in human studies and contextualize them considering previous preclinical models

Xenograft mouse model was generated to investigate the in vivo efficacy of fentanyl.

July 2022 "I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics

high-resolution techniques to investigate peptidergic transmission and expression throughout the brain in model Neuropeptides exhibit distinct characteristics which includes their post-translational processing, release

& Updates in GPCR Research A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation

Dose prediction models need kinetic nuance—not just Cmax and AUC. You can’t model irreversible binding with the usual tools.