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Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma

September 2022


Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury


"Traumatic brain injury (TBI) is a leading cause of disability in the US. Angiotensin 1-7 (Ang-1-7), an endogenous peptide, acts at the G protein coupled MAS1 receptors (MASR) to inhibit inflammatory mediators and decrease reactive oxygen species within the CNS. Few studies have identified whether Ang-(1-7) decreases cognitive impairment following closed TBI. This study examined the therapeutic effect of Ang-(1-7) on secondary injury observed in a murine model of mild TBI (mTBI) in a closed skull, single injury model."


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