Targeting Intracellular Allosteric Sites in GPCRs
GPCR News
- Aug 21, 2023
- 5 min
Decoding β-Arrestins: from Structure to function
- Jun 28, 2023
- 7 min
Structural landscape of the Chemokine Receptor system
- May 16, 2023
- 5 min
Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
- Nov 1, 2022
- 1 min
Emerging approaches for decoding neuropeptide transmission
- Nov 1, 2022
- 1 min
Location bias contributes to functionally selective responses of biased CXCR3 agonists
- Nov 1, 2022
- 1 min
Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
- Nov 1, 2022
- 1 min
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
- Nov 1, 2022
- 1 min
Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
- Nov 1, 2022
- 1 min
Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
- Nov 1, 2022
- 1 min
Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv
- Oct 1, 2022
- 1 min
High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
- Oct 1, 2022
- 1 min
Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
- Oct 1, 2022
- 1 min
Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...
- Oct 1, 2022
- 1 min
Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures
- Oct 1, 2022
- 1 min
Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
- Oct 1, 2022
- 1 min
Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to...
- Oct 1, 2022
- 1 min
Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
- Oct 1, 2022
- 1 min
Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...
- Oct 1, 2022
- 1 min
Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..