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Targeting Intracellular Allosteric Sites in GPCRs

Nov 1, 20234 min read

245

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Decoding β-Arrestins: from Structure to function

Aug 21, 20235 min read

160

0

Structural landscape of the Chemokine Receptor system

Jun 28, 20237 min read

166

1

Artificial intelligence – faster, smarter, cheaper GPCR drug discovery

May 16, 20235 min read

231

0

VAMP2: a crucial player in the delivery of MOR to the synapse

Monserrat Avila-Zozaya

Apr 21, 20233 min read

61

0

Feeder or trigger – CCR2 as a scavenger and regulator of cell migration

Apr 11, 20234 min read

80

0

Glyco-sulfo hotspots in the chemokine receptor system

Feb 23, 20234 min read

107

0

Odorant receptors – a bit of smell for drug discovery

Jan 13, 20234 min read

160

0

Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery

Dec 6, 20223 min read

208

0

Emerging approaches for decoding neuropeptide transmission

Nov 1, 20221 min read

16

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Location bias contributes to functionally selective responses of biased CXCR3 agonists

Nov 1, 20221 min read

40

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Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...

Nov 1, 20221 min read

22

0

Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Nov 1, 20221 min read

28

0

Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

Nov 1, 20221 min read

27

0

Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors

Nov 1, 20221 min read

19

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Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv

Nov 1, 20221 min read

62

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High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...

Oct 1, 20221 min read

10

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Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

Oct 1, 20221 min read

9

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Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...

Oct 1, 20221 min read

3

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Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures

Oct 1, 20221 min read

8

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Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...

Oct 1, 20221 min read

6

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Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to...

Oct 1, 20221 min read

112

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Structural view of G protein-coupled receptor signaling in the retinal rod outer segment

Oct 1, 20221 min read

5

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Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...

Oct 1, 20221 min read

5

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