Emerging approaches for decoding neuropeptide transmission
November 2022 "Neuropeptides produce robust effects on behavior across species, and recent research has benefited from advances in...
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GPCR News
- Nov 1, 2022
- 1 min
Location bias contributes to functionally selective responses of biased CXCR3 agonists
November 2022 "Some G protein-coupled receptor (GPCR) ligands act as "biased agonists" that preferentially activate specific signaling...
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GPCR News
- Nov 1, 2022
- 1 min
Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
November 2022 Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis...
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GPCR News
- Nov 1, 2022
- 1 min
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
November 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed the location of allosteric binding...
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GPCR News
- Nov 1, 2022
- 1 min
Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies. A hallmark of aGPCR...
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GPCR News
- Nov 1, 2022
- 1 min
Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
November 2022 "Despite the growing number of G protein-coupled receptor (GPCR) structures, only 39 structures have been cocrystallized...
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GPCR News
- Nov 1, 2022
- 1 min
Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv
November 2022 "Dimerization of beta 2-adrenergic receptor (β2-AR) has been observed across various physiologies. However, the function of...
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GPCR News
- Oct 1, 2022
- 1 min
High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
October 2022 High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR...
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GPCR News
- Oct 1, 2022
- 1 min
Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
October 2022 "Arrestins interact with G protein-coupled receptors (GPCRs) to stop G protein activation and to initiate key signaling...
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GPCR News
- Oct 1, 2022
- 1 min
Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...
October 2022 Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias and disrupts the...
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GPCR News
- Oct 1, 2022
- 1 min
Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures
October 2022 "G protein-coupled receptors (GPCRs) are important drug targets characterized by a canonical seven transmembrane (TM) helix...
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GPCR News
- Oct 1, 2022
- 1 min
Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
October 2022 Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density,...
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GPCR News
- Oct 1, 2022
- 1 min
Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to...
October 2022 Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inverse agonism...
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GPCR News
- Oct 1, 2022
- 1 min
Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
October 2022 "Visual phototransduction is the most extensively studied G protein-coupled receptor (GPCR) signaling pathway because of its...
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GPCR News
- Oct 1, 2022
- 1 min
Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...
October 2022 Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy Number Variants in ADGRL3...
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GPCR News
- Oct 1, 2022
- 1 min
Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..
October 2022 Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for...
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GPCR News
- Oct 1, 2022
- 1 min
Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
October 2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat...
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GPCR News
- Oct 1, 2022
- 1 min
Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
October 2022 "Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved...
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GPCR News
- Oct 1, 2022
- 1 min
Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
October 2022 "Understanding the activation of G protein-coupled receptors (GPCRs) is of paramount importance to the field of...
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GPCR News
- Oct 1, 2022
- 1 min
Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
October 2022 "Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various...
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