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Results found for "GPCR Pharmacology"
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
Methods: Immunohistochemistry, western blot and quantitative real-time PCR techniques were used to analyze Read more at the source #DrGPCR #GPCR #IndustryNews
- Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
Prokineticins (PKs) exert their biological functions through the activation of the G protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890
October 2022 "Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular They can also function independently of GPCR activation upon acquiring mutations that prevent GTPase YM-254890 (YM) can inhibit signaling by both GPCR-activated wild type αq and GPCR-independent αqQ209L GPCR-dependent signaling by PM-restricted wild type αq is strongly inhibited by YM, demonstrating that Read more at the source #DrGPCR #GPCR #IndustryNews
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- Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
Read more at the source #DrGPCR #GPCR #IndustryNews
- Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders with ...
April 2022 Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders Addex Therapeutics "Tim Dyer is the Co-Founder and CEO of Addex Therapeutics, which is focusing on the pharmacology Read more at the source #DrGPCR #GPCR #IndustryNews
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- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
Protein Interaction "The calcium-sensing receptor is a homodimeric class C G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
Read more at the source #DrGPCR #GPCR #IndustryNews
- Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
Protein in the Allosteric Regulation of Adhesion Receptor GPR97 "Adhesion G-protein-coupled receptors (aGPCRs )-a major family of GPCRs-play critical roles in the regulation of tissue development and cancer progression The orphan receptor GPR97, activated by glucocorticoid stress hormones, is a prototypical aGPCR. of the Go protein, and offers guidance for future drug design of aGPCRs." Read more at the source #DrGPCR #GPCR #IndustryNews
- Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
and mediate intracellular pathway bias "Within the intestine, the human G protein-coupled receptor (GPCR The pharmacological profiles and mechanistic insights of our study provide clues for the future design Read more at the source #DrGPCR #GPCR #IndustryNews
- Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
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- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
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- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
Read more at the source #DrGPCR #GPCR #IndustryNews
- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
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- Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water ...
Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea Diaphanosoma celebensis G protein-coupled receptors (GPCRs) are considered to have originated from early evolution of eukaryotic species, therefore, the genome-wide identification of GPCR genes can provide Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis In this study, these results may provide a better understanding on the evolution of GPCRs, and expand
- Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
Read more at the source #DrGPCR #GPCR #IndustryNews
- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors (vGPCRs This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from Read more at the source #DrGPCR #GPCR #IndustryNews
- All About Addgene: More Open and Reproducible Science with Materials Sharing
GPCR Virtual Cafe? Register today! Addgene's Dr. Joanne Kamens is our guest. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe / #gpcr #drgpcr #virtualcafe #addgene
- Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and analogues for their pharmacologic Read more at the source #DrGPCR #GPCR #IndustryNews
- Why Dose-Response Curves Are Pharmacology’s Secret Weapon
In the newest foundational lesson from Terry Kenakin’s Pharmacology Vault , we unlock the visual language of pharmacology: dose-response curves . 👉 Discover why dose-response curves are the backbone of all pharmacology.
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
Methods Immunohistochemistry staining and RT–qPCR analyses were performed to detect the correlation of Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction Read more at the source #DrGPCR #GPCR #IndustryNews
- Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
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- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
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- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
Quantitative real-time probe-based polymerase chain reaction (qRT-PCR) assays are deployed in order to This can be deduced from the qRT-PCR assays; triggering CB1 receptors amplifies both NR4A1 and NR4A3 Read more at the source #DrGPCR #GPCR #IndustryNews
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
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- Glyco-sulfo hotspots in the chemokine receptor system
effects of O-glycosylation and tyrosine sulfation modulation on the chemokine receptors CCR1 and CCR5 pharmacology evidence proposes that O-glycosylation and sulfation are important PTMs in chemokine receptor biology and pharmacology Check the original article at https://pubmed.ncbi.nlm.nih.gov/36729338/ #GPCR #DrGPCR#Ecosystem
- Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
Read more at the source #DrGPCR #GPCR #IndustryNews
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein Read more at the source #DrGPCR #GPCR #IndustryNews
