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in multiple immune signaling processes and is dependent on activation by Ras and G protein-coupled receptors

Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors

Must-read publications:  AT1R β-arrestin bias; UII receptor structure; β2AR constant-pH dynamics.

Must-read publications: D2 receptor constitutively active mutants; β2AR allosteric SERS assay; CXCR4

Even perfect receptor pharmacology fails if target-site exposure is insufficient or transient .

The surface expression of pattern recognition receptors, such as TLR2 and TLR4, provides platelets with

September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein

– Assay Volume Control in GPCR Drug Discovery This week in Terry’s Corner, you’ll learn how dialing receptor

We demonstrate that the chemoreceptor genes, srg-36 and srg-37, which encode G protein-coupled receptors

β-arrestin2 is a key protein that mediates desensitization and internalization of G protein-coupled receptors

The aim of this study was to identify Gα proteins mediating function of neuronal G protein-coupled receptors

What happens when receptor expression is different? What happens in vivo?

BAI1 is expressed in the afferent spiral ganglion neurons in the mouse cochlea where it localizes AMPA receptors

Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates

Dual-label specificity blocks promiscuous ligand confusion Lanthanide donors + d2 acceptors = high SNR