Search Results

a patient with a specific variant of the β2AR gene that reduces potency might require a higher drug dose evolutionary conservation of these residues can lead to the development of drugs that are less likely to lose

Their “aha” moment came when they ran a dose-response with Exendin-4 on GLP-1 receptors—and saw clean

uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F Industry News Sosei Heptares Doses

Sometimes you’re working with linear fits: Schild plots, dose ratios, regression models.

lesson shows how to replace inference with models that disentangle mechanism—so your next go/no-go, dose

EyeBio Announces First Patients Dosed in Phase 1b/2 Trial of Restoret™ in Neovascular Age Related Macular

receptor sensor GPCRs in Oncology and Immunology Phase 1/2 study of sorafenib added to cladribine, high-dose

If you’ve ever stared at a dose–response curve and wondered, “Is this partial agonism?

and Immunology GPCRs and fibroblast heterogeneity in fibroblast-associated diseases Ultrasensitive dose-response neuropeptide transmission Nanowire Biosensors with Olfactory Proteins: Towards a genuine electronic nose

Recursion and Exscientia have merged to enhance drug discovery GPCR Classes Pathios Therapeutics Announces Dosing

This week in Terry’s Corner , we go beyond the dose-response curves to explore the kinetic and pharmacologic

molecular redundancy, pointing out that, in some cases, inappropriate target selection and insufficient dosing

Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo , Iu Raïch , Ana Rodríguez-Pérez , Gemma Navarro , José

of adjustability in terms of pharmacological effects, allowing for the administration of substantial doses

tagging and interrogation of GPCR co-internalization Kilian Roßmann , Ramona Birke , Joshua Levitz , Ben Jones

team in Oxford, buying out a fledgling biotech for $255M+ Domain Therapeutics announces first patient dosed

of adjustability in terms of pharmacological effects, allowing for the administration of substantial doses

ORs are highly expressed by olfactory sensory neurons of the nose where they are activated by different epithelial cells proliferation via activation by β-ionone which initiates prostate cancer cell cycle arrest (Jones

Twice-daily treatment with mOB-004 dose-dependently suppressed monocyte infiltration into the peritoneum cavity, achieving complete blockade at the highest dose level.

GPCR-related knowledge, AI can help identify patient-specific GPCR targets and optimize drug selection and dosing