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And yet, many founders walk out of their first FDA conversation with a quiet sense of confusion . 👉 The Illusion of Readiness 👉 Many biotech founders walk into a pre-IND meeting with quiet confidence mindset plays out in practice: You align trial endpoints with future label claims , not just scientific curiosity

What followed — a trip to London, confocal imaging marathons, and a partnership built on trust and curiosity That brief exchange connected two people who had never met but were equally driven by curiosity. For a field that depends on understanding where receptors actually are — and how many are available at Chemical probes may be elegant, but biology isn’t. Tissue is messy. Curiosity also played a central role.

Like many, it was a mix of opportunity, timing, and the courage to say yes before everything was figured Mini Timeline: Manual assay years — technical rigor as foundation Technology boom — scaling curiosity

And somewhere between the results and the unknown, curiosity turned into obsession. Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan. The Moment It Clicked Once the initial spark was lit, Michelle’s curiosity snowballed. Not from polished plans—but from patterns of curiosity, risk-taking, and mentorship loops. Curiosity → Ownership → Opportunity → Leadership → Innovation.

Curiosity compounds. And paths reveal themselves while walking. That brought him to type 2 diabetes  — a condition affecting nearly every family, marked by social and Skills + respect + shared curiosity = long-term impact. The “Aha” Moment — Ten Years in the Making Many discoveries unfold slowly — dozens of experiments that For Hodson, one sustained curiosity thread involved a protein released by alpha cells in the pancreas

But here’s the truth: too many programs still fail because early decisions were built on shaky mechanistic Allosteric Interactions Only in Terry’s Corner 🎬 Plus New: Lesson Trailers   Curious about Terry’s Corner

Predictive GPCR-Ligand Modeling Carlsson's work quickly shifted from curiosity to impact. For Carlsson, this marked a shift in how his lab approached GPCR research. Many of his former students now work in industry, where their ability to bridge the computational-experimental a field where major publications and grant awards can be rare, finding satisfaction in an optimized curve GPCR Podcast 💡 Stay curious. Stay connected. Looking for more insights like this? The Dr.

Improving slides or polishing the pitch may reduce surface-level friction, but the core problem remains This puts the burden of synthesis on the listener , who may not share the same context or priorities. early Questions move from explanation to evaluation , signaling real engagement rather than polite curiosity What Biotech Positioning Strategy Really Means 👉 Many biotech founders misunderstand positioning because

Kotliar sums it up best: “We went from one receptor to many… and now, from many, we can go back to one

The dysfunction of these receptors has been linked to the development of many serious pathologies, like Binding curves of CELT-419 binding to D3 receptors in BBVs. The insert shows the Log(IC50) ± SE change in time of corresponding displacement curves. If you are curious about the material and methods or want more information, here is the published article G.; Puri, V.; Singh, R. D.; Hanada, K.; Pagano, R. E.; Miller, L. J.

This is where many biotech founders lose visibility. They know how many months of runway remain, but not which strategic options are already gone . Burn rate creates the illusion of control 👉 Many biotech founders  believe they are in control because It tells you how fast cash is leaving the company, but it does not tell you how many meaningful choices When building quietly turns into surviving 👉 At a certain point, many biotech founders  believe they

where different ligands acting on the same receptor trigger distinct signaling pathways, leading to varied Cary, B.P., et al., New Insights into the Structure and Function of Class B1 GPCRs.  

Many pharmacology experiments produce beautifully clean assay curves. Key realities pharmacologists face: Assays measure one slice of biology Disease physiology involves many be estimated rather than exact In practice, the precise maximal signal matters less than many assume A ligand may show identical EC₅₀ values in two assays while engaging receptors through very different Even potent inhibitors may fail simply because they never reach sufficient concentration in vivo .

Computational Biochemistry at Uppsala University and one of the strongest advocates for an approach that too many Closing the Trust Gap If collaboration is so effective, why do so many labs avoid it? Many startups chase elaborate simulations that look impressive on paper but do little to move drug discovery Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening Overstating the precision of a model or the predictive power of an assay may look persuasive in the short

Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting

Maria Majellaro, the transition from lab work to leadership wasn’t meticulously planned, it was a bold Maria Majellaro Maria’s career didn’t start with a desire to launch a company. It began in Bari, Italy, with a love for science nurtured by her father and fueled by childhood cartoons The academic group Maria worked with had developed a technology that allowed for flexible, fast synthesis

The receptor samples many states. traps: distributed networks of interactions that hold the receptor in an active state by satisfying many suggests that the difficulty an orthosteric small-molecule agonist program encounters at a family B GPCR may A series that shows good binding and weak activation, repeatedly, may be encountering the limit of what

Recently, AlphaFold2 has been developed to predict structure models of many functionally important proteins However, the predicted models and experimental structures were different in many aspects including the

. 👉 Many founders ask why biotech startups fail  not after a collapse, but when the company starts to Strategy as a system for making fewer better decisions The turning point for many biotech startups comes This is where many teams escape the typical pattern of why biotech startups fail .

Terry Kenakin’s session examines not just how  binding works, but why  so many datasets mislead even But plotting on a logarithmic axis exposes how far the system may actually be from true saturation. After a ligand binds, the receptor may transition further—often via G protein coupling. Many programs unknowingly compare compounds measured under different kinetic biases. You may see: Early stopping → potency distortions Different stopping times → incomparable datasets Curve

Data represent the mean ± SEM (n = 5 in triplicates). ( a ) concentration/response curves obtained for agonists; ( b ) concentration/response curves obtained for the antagonists. 2.3  CELT-335 HTRF Assay Data represent the mean ± SEM (n = 5 in triplicates). ( a ) concentration/response curves obtained for agonists; ( b ) concentration/response curves obtained for the antagonists. 3.       The curves obtained using this concentration of probe in the Tag-lite® assays are reproducible sigmoidal

When too many priorities advance in parallel, focus starts to diffuse. Resources stretch. The scientific ambition may be impressive, yet the strategic narrative loses sharpness. When too many priorities move in parallel, several things happen at onc e: 👉 The primary value inflection When resources are spread across too many initiatives, demonstrating alignment becomes harder. 👉 Strategic That decline may not disrupt daily operations, but it quietly weakens positioning long before biotech

Results show that for each of the 21 structures with bound ligands there exist many other GPCRs that These sites cluster at nine distinct locations, and each can be found in many different proteins.

splicing events account for hundreds, if not thousands, of potentially divergent isoforms throughout many This might not be a big deal for many, but in this new era of making sure that historically excluded Pyramids: although it is very touristy, it is just a hop away from Mexico City and finds its way on many However, Reggaetón is a highly dynamic genre that attracts many here in Mexico, not to forget salsa music

Many such biosensors are based on the principle of Förster resonance energy transfer (FRET), and we have This methodology would be compatible with other mammalian species and with many biosensors.

In reality, many biotech startups drift into trouble without ever making a single decision that looks The problem is not one bad move, but the quiet accumulation of many small choices that are never evaluated It forms when many reasonable decisions are never examined as part of a system. Metrics may even look acceptable.

Curiosity as the Engine Behind Asking Better Questions in Science JB’s story makes one thing clear: asking Throughout his training, he treated curiosity not as a trait but as a deliberate method. Following curiosity is the first step toward asking better questions in science. When curiosity becomes intentional, questions become easier, sharper, and more useful. It may just require walking across the room and asking one thoughtful question.

Yet curiosity and chemistry pulled him into the world of GLP-1R, pancreatic β-cells, and the biological

👥We have many surprises in reserve for you at the next Dr.

It started with curiosity, openness, and the humility to admit that better answers required better tools If this story resonates with your work or curiosity, go deeper. 🎧 Listen to the full conversation with