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And somewhere between the results and the unknown, curiosity turned into obsession. Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan. The Moment It Clicked Once the initial spark was lit, Michelle’s curiosity snowballed. Not from polished plans—but from patterns of curiosity, risk-taking, and mentorship loops. Curiosity → Ownership → Opportunity → Leadership → Innovation.

Curiosity compounds. And paths reveal themselves while walking. That brought him to type 2 diabetes  — a condition affecting nearly every family, marked by social and Skills + respect + shared curiosity = long-term impact. The “Aha” Moment — Ten Years in the Making Many discoveries unfold slowly — dozens of experiments that For Hodson, one sustained curiosity thread involved a protein released by alpha cells in the pancreas

But here’s the truth: too many programs still fail because early decisions were built on shaky mechanistic Allosteric Interactions Only in Terry’s Corner 🎬 Plus New: Lesson Trailers   Curious about Terry’s Corner

Predictive GPCR-Ligand Modeling Carlsson's work quickly shifted from curiosity to impact. For Carlsson, this marked a shift in how his lab approached GPCR research. Many of his former students now work in industry, where their ability to bridge the computational-experimental a field where major publications and grant awards can be rare, finding satisfaction in an optimized curve GPCR Podcast 💡 Stay curious. Stay connected. Looking for more insights like this? The Dr.

Kotliar sums it up best: “We went from one receptor to many… and now, from many, we can go back to one

The dysfunction of these receptors has been linked to the development of many serious pathologies, like Binding curves of CELT-419 binding to D3 receptors in BBVs. The insert shows the Log(IC50) ± SE change in time of corresponding displacement curves. If you are curious about the material and methods or want more information, here is the published article G.; Puri, V.; Singh, R. D.; Hanada, K.; Pagano, R. E.; Miller, L. J.

Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting

where different ligands acting on the same receptor trigger distinct signaling pathways, leading to varied Cary, B.P., et al., New Insights into the Structure and Function of Class B1 GPCRs.  

Recently, AlphaFold2 has been developed to predict structure models of many functionally important proteins However, the predicted models and experimental structures were different in many aspects including the

Computational Biochemistry at Uppsala University and one of the strongest advocates for an approach that too many Closing the Trust Gap If collaboration is so effective, why do so many labs avoid it? Many startups chase elaborate simulations that look impressive on paper but do little to move drug discovery Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening Overstating the precision of a model or the predictive power of an assay may look persuasive in the short

Maria Majellaro, the transition from lab work to leadership wasn’t meticulously planned, it was a bold Maria Majellaro Maria’s career didn’t start with a desire to launch a company. It began in Bari, Italy, with a love for science nurtured by her father and fueled by childhood cartoons The academic group Maria worked with had developed a technology that allowed for flexible, fast synthesis

Results show that for each of the 21 structures with bound ligands there exist many other GPCRs that These sites cluster at nine distinct locations, and each can be found in many different proteins.

Many such biosensors are based on the principle of Förster resonance energy transfer (FRET), and we have This methodology would be compatible with other mammalian species and with many biosensors.

splicing events account for hundreds, if not thousands, of potentially divergent isoforms throughout many This might not be a big deal for many, but in this new era of making sure that historically excluded Pyramids: although it is very touristy, it is just a hop away from Mexico City and finds its way on many However, Reggaetón is a highly dynamic genre that attracts many here in Mexico, not to forget salsa music

👥We have many surprises in reserve for you at the next Dr.

The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways The GloSensor™ cAMP assay enables real-time monitoring of signaling downstream of many GPCRs. However, thermal instability of the biosensor may pose a problem for in vivo studies.

Data represent the mean ± SEM (n = 5 in triplicates). ( a ) concentration/response curves obtained for agonists; ( b ) concentration/response curves obtained for the antagonists. 2.3  CELT-335 HTRF Assay Data represent the mean ± SEM (n = 5 in triplicates). ( a ) concentration/response curves obtained for agonists; ( b ) concentration/response curves obtained for the antagonists. 3.       The curves obtained using this concentration of probe in the Tag-lite® assays are reproducible sigmoidal

It started with curiosity, openness, and the humility to admit that better answers required better tools If this story resonates with your work or curiosity, go deeper. 🎧 Listen to the full conversation with

If this story resonates with your work or curiosity, go deeper. 🎧 Listen to the full conversation with

Kenakin Trusted insights from biotech, pharma, and academia 🎬 Plus New: Lesson Trailers   Curious about

Stay curious! The Dr. GPCR Team

Maria Majellaro, highlighting their fluorescent ligand tools for live-cell GPCR assays.   Maria Majellaro of Celtarys shares how her team translates medicinal chemistry into practical GPCR assay Stay curious, The Dr. GPCR Team

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. 🎬 Plus New: Lesson Trailers   Curious about Terry’s Corner before committing? Your team’s next good decision may start here 🚀 Join Premium Today & Enjoy ➤ 🎓 Full GPCR University

More than a technical overview, this is a story of curiosity, persistence, and using science to meet It was investor rejections, endless slide decks, and the steep learning curve of biotech business.

If you are curious about fluorescent probes, fluorescent probe design or GPCR tools, feel free to contact Br J Pharmacol. 2020 Mar;177(5):978-991. doi: 10.1111/bph.14953.

Under certain experimental conditions, what appears to be a second high-affinity site may simply reflect GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The technologies overcoming peptide limitations with insights from both pharma and startup environments Read Maria Pin built an in vitro pharmacology group from scratch—not just a lab, but a culture that encouraged curiosity leadership principles: Hire for attitude and team fit—not just credentials Design workflows that enable curiosity-driven

. 📍 Foundational Level | Calcium Assays 📚 Part of Terry Kenakin’s Pharmacology Vault 👉 Curious what

Takeaway Science isn’t always about curiosity. Sometimes, it’s about necessity. Dr.

hired based on attitude and team fit , not just credentials He designed lab workflows that encouraged curiosity