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oriental fruit moth Grapholita molesta is a cosmopolitan pest of orchard, which causes serious economic losses

The takeaway is clear: fast clearance does not necessarily mean loss of efficacy  when binding offset

Breakthroughs this week:  Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

discoveries could revolutionise women’s health Seven unanswered questions about blockbuster weight-loss

DR curves shift to the right with no loss of maximal effect.

novel fluorescent Endothelin-B receptor probes GPCRs in Cardiology, Endocrinology, and Taste GPRASP1 loss-of-function

loop 2 in the β2-adrenergic receptor mediates interactions with G protein and β-arrestin with a biased loss

was significantly diminished iin Gαi KO and Gα_all KO HEK293 cells, however there was only a minor loss HEK293 cells with CRISPR KO of both β-arrestin1 and β-arrestin2 only led to a small but measurable loss

analysis Reviews, GPCRs, and more Parallel evolution of the G protein-coupled receptor GrlG and the loss

Industry News Data shows nearly 19% weight loss in people with overweight or obesity in Boehringer Ingelheim

dive into the Classified GPCR News from April 1st to 7th, 2024 GPCR Activation and Signaling GPRASP1 loss-of-function

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.

Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Adhesion GPCRs Loss

The on-rate/off-rate balance  matters: too tight, and penetration stalls; too loose, and efficacy dissipates

Rodriguez, P.J., et al., Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss

droplets; novel atypical GPCR-arrestin complexes; Lilly's oral GLP-1, orforglipron, delivers weight loss

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7 Loss-of-function

from November 25th to December 1st, 2024 Industry News Amgen says obesity drug caused up to 20% weight loss

Scutellaria baicalensis Georgi stems and leaves flavonoids promote neuroregeneration and ameliorate memory loss