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Results found for "Thomas P Sakmar"
- Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR
P., Macdonald, C. B., Mehrota, E., Grimes, P. R., ... & Manglik, A. (2024).
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Hunter P. Persechino M, Hedderich JB, Kolb P, Hilger D. Changeux J-P, Christopoulos A. González-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, et al. Rößler P, Mayer D, Tsai CJ, Veprintsev DB, Schertler GFX, Gossert AD.
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
FLNA absence reduced the basal number of hetero-dimers (-36.8 ± 6.3% reduction of PLA events in M2, P both A7 and M2 (+20.0 ± 11.8% and +44.1 ± 16.3% increase of PLA events in A7 and M2, respectively, P
- The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in ...
The fission yeast Schizosaccharomyces pombe has two mating types, Plus (P) and Minus (M). Here, we investigated the stringency of the two GPCRs, Mam2 and Map3, for their respective pheromones, P-factor
- From DNA day to GPCR genomics
B., Panova, O., Hilger, D., Casiraghi, M., He, F., Maul, L., Gmeiner, P., Kobilka, B. K., Hildebrand, P. W., & Skiniotis, G. (2023).
- Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...
. -11.6 placebo, p<0.0001) at Week 5 (Cohen’s d effect size of 0.61).
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
Associated with Huntington Disease "Highly Statistically Significant Reduction in Chorea Movements (p
- Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
affinities from previous studies.[13] Besides traditional dopaminergic ligands, the affinities of the P- Therapeutics 2016 , 165 , 164–177. https://doi.org/10.1016/j.pharmthera.2016.06.007 . (2) Sokoloff, P. P. U.; Lüdeke, S.; Koch, P.; Rinken, A.; Keller, M. T.; Schwille, P.; Jungmann, R.
- Overview of adhesion GPCRs self-activation
Embo j, 2012. 31(6): p. 1364-78. 2. Xiao, P., et al., Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 2022. 604(7907): p. 628-630. 7.
- Conjugation Strategies for Probe Development
.; Allongue, P.; Chazalviel, J.-N.; Gouget-Laemmel, A.
- Dynamic GPCR activation revealed through time-resolved Cryo-EM
As GTP stabilizes and migrates towards the P loop, it causes the TCAT motif to shift, a key movement
- Decoding β-Arrestins: from Structure to function
bioinformatics tools offer the potential to explore larger portions of the β-arrestin interactome (Crépieux, P. with overlapping sites may experience mutually exclusive binding due to steric hindrance (Crépieux, P.
- 📰 GPCR Weekly News, May 27 to June 2, 2024
contributor article Canonical chemokine receptors as scavenging “decoys” Shivani Sachdev, Brendan Creemer, Thomas
- GPCR News Flash! Top Updates You Can't-Miss! + University CheatSheet is finally available! ❄ Dec 2 - 8, 2024
coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function Szymon P
- Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery
and TM7 on the other hand, form possible dimerization interfaces (Ploier, B. et al. 2016; Dijkman, P.
- 📰 GPCR Weekly News, November 13 to 19, 2023
challenge in the Dahl SS rat GPCRs in Neuroscience Neurokinin-2 receptor negatively modulates substance P
- 🤯Mind-blowing GPCR Scoops! Discover the Latest Breakthroughs! ⦿ Nov 18 - 24, 2024
receptors, data mapper, structure similarity search and models of physiological ligand complexes Luis P
- Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
-P., Macdonald, C. B., Mehrotra, E., Patrick Rockefeller Grimes, Zahm, A. M., Trinidad, D.
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
They also showed higher protein levels of phospho-glycogen synthase kinase-3β (p-GSK3β), as well as total
- Adhesion GPCR Consortium Newsletter - May 2024
Thomas Südhof, but did not start working on them right away.
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
Toxicol. 52, 179–197. https://doi.org/10. 1146/annurev.pharmtox.010909.105800 Tsao, P.
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
towards previously established chemical space, limiting their ability to identify truly novel chemotypes”(Thomas
- 📰 GPCR Weekly News, June 3 to June 9, 2024
Aylin Hanyaloglu, Caroline Gorvin, and Alejandra Tomas.
- 📰 GPCR Weekly News, July 1 to 7, 2024
Alejandra Tomas, et al. for their research on Engineered mini-G proteins block the internalization of
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
Structural explanation of the receptor binding mechanism of a highly potent antagonist analog Isaikina, P.
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
ß-arrestin functional specificity at C-X-C chemokine receptor 5 (CXCR5) Panjamaporn Sangwung , Alejandra Tomas
- 📰 GPCR Weekly News, May 6 to 12, 2024
Alejandra Tomas, et al. for their study on Lipid regulation of the glucagon receptor family Drs.












